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New Insights and Research on Nutrition and Obesity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 465

Special Issue Editor


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Guest Editor
Center for Obesity Research and Education (CORE), Robert Gordon University, Aberdeen AB10 7AQ, UK
Interests: obesity; non-alcoholic fatty liver disease; cancer; molecular nutrition; natural product; oxidative stress
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Special Issue Information

Dear Colleagues,

Global health is the main target for several United Nations Sustainable Development Goals (SDGs); however, both the obesity epidemic and obesity-associated diseases, affecting both developed and developing countries, represent major obstacles to the achievement of these goals. Traditionally, global health has focused on two distinct issues in nutrition: overnutrition, which includes being overweight or obese, and undernutrition, which includes being underweight or having nutrient deficiencies. However, both conditions are increasingly being seen in the same population, and the double burden of malnutrition plays an important part in the pathology of obesity-related diseases. It is, therefore, paramount to better characterize the importance of nutrition and specific nutrients as risk factors for disease susceptibility and severity: this can only be achieved if the cellular and molecular mechanisms affected by nutrients in the context of obesity and chronic diseases are fully elucidated.

This Special Issue will focus on research aimed at determining molecular links between nutrition and obesity or associated diseases in different population groups. Studies that aim to characterize the molecular mechanisms by which nutrition or nutrients may contribute to the prevention, management, or treatment of obesity and associated diseases and provide more specific guidance for sub-groups whose nutrient requirements may differ substantially from the norm will be considered for publication. These studies will help to understand the relevance of optimal and sustainable nutrition in the implementation of preventive approaches for optimizing health, delaying the onset of disease, and diminishing its severity.

Prof. Dr. Giovanna Bermano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • nutrition
  • obesity
  • malnutrition
  • overnutrition
  • molecular and cellular mechanisms
  • nutrient–gene interactions
  • metabolic disorders

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Published Papers (1 paper)

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Research

14 pages, 2737 KiB  
Article
High-Protein Diet Prevents Glucocorticoid-Induced Fat Mass Accumulation and Hyperglycemia
by Susan J. Burke, Heidi M. Batdorf, Maggie P. Ducote, Thomas M. Martin, Michael D. Karlstad, Robert C. Noland, Sujoy Ghosh, Christopher D. Morrison and J. Jason Collier
Int. J. Mol. Sci. 2025, 26(9), 4212; https://doi.org/10.3390/ijms26094212 - 29 Apr 2025
Viewed by 100
Abstract
Glucocorticoid-induced diabetes is the most common form of drug-induced hyperglycemia. In addition, chronic exposure to glucocorticoids promotes lean mass loss and fat mass accumulation. In this study, we hypothesized that a high-protein diet (60% kcal; HPD) would help to offset sarcopenia during oral [...] Read more.
Glucocorticoid-induced diabetes is the most common form of drug-induced hyperglycemia. In addition, chronic exposure to glucocorticoids promotes lean mass loss and fat mass accumulation. In this study, we hypothesized that a high-protein diet (60% kcal; HPD) would help to offset sarcopenia during oral administration of corticosterone to C57BL/6J mice. Carbohydrates were reduced in the HPD to ensure it was isocaloric with the normal-protein diet (20% kcal; NPD). We found that the HPD prevented fat mass accumulation but did not protect against reductions in lean mass in both male and female mice. Mice consuming a HPD did not develop hyperglycemia, while mice given the NPD developed hyperglycemia within two weeks. The HPD diet did not improve insulin sensitivity in response to glucocorticoids but did alter gene expression patterns in adipose tissue and liver measured by RNA sequencing. We conclude that a HPD diet may be beneficial to limit rises in blood glucose and adipose tissue accrual during glucocorticoid therapy. Full article
(This article belongs to the Special Issue New Insights and Research on Nutrition and Obesity)
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