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New Perspectives on Prostate Cancer Occurrence, Diagnosis, and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1087

Special Issue Editors


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Guest Editor
Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, “G. d'Annunzio” University of Chieti, Chieti, Italy
Interests: kidney disease; kidney damage; kidney inflammation
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Guest Editor
Department of Urology, “Padre Pio da Pietrelcina” Hospital, Via S. Camillo del Lellis, 66054 Vasto, Italy
Interests: prostate cancer; urology; kidney cancer; prostate; urologic oncology; endourology; urolithiasis; robotics & minimally invasive urology; surgical oncology; BPH
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear colleagues,

Prostate cancer is a leading malignancy in men, and recent molecular advances are transforming our understanding of its occurrence, diagnosis, and treatment. Key genetic alterations, such as BRCA1/2, PTEN, and TP53 mutations, as well as the TMPRSS2-ERG fusion, are now recognized as drivers of prostate cancer progression. Molecular biomarkers, including circulating tumor cells and DNA methylation patterns, are enhancing diagnostic precision and risk stratification.

In treatment, personalized medicine is becoming a reality with targeted therapies, such as PARP inhibitors, for BRCA-mutated tumors. Immunotherapies, encompassing immune checkpoint inhibitors and CAR-T cells, are also gaining attention, although prostate cancer's immunologically "cold" nature poses challenges. Epigenetic modifications are another frontier, with therapies aimed at reversing these changes showing promise.

This Special Issue welcomes contributions that focus on molecular insights into prostate cancer to advance diagnosis and treatment strategies.

Dr. Michele Marchioni
Prof. Dr. Luigi Schips
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • prostate cancer
  • biomarker
  • diagnosis
  • treatment

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Published Papers (1 paper)

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Research

15 pages, 2088 KiB  
Article
Personalized High-Resolution Genetic Diagnostics of Prostate Adenocarcinoma Guided by Multiparametric Magnetic Resonance Imaging: Results of a Pilot Study
by Jacek Wilkosz, Dariusz Wojciech Sobieraj, Tadeusz Kałużewski, Jakub Kaczmarek, Jarosław Szwalski, Michał Bednarek, Agnieszka Morel, Żaneta Kasprzyk, Łukasz Kępczyński, Jordan Sałamunia, Agnieszka Gach and Bogdan Kałużewski
Int. J. Mol. Sci. 2025, 26(12), 5648; https://doi.org/10.3390/ijms26125648 - 12 Jun 2025
Viewed by 689
Abstract
The upcoming wave of personalized medicine, driven by genomic diagnostics and artificial intelligence, demands clearly defined pre-laboratory and laboratory procedures to ensure the acquisition of DNA and RNA of sufficient quantity and quality. In prostate cancer oncogenetics, diagnostic and prognostic assessments increasingly rely [...] Read more.
The upcoming wave of personalized medicine, driven by genomic diagnostics and artificial intelligence, demands clearly defined pre-laboratory and laboratory procedures to ensure the acquisition of DNA and RNA of sufficient quantity and quality. In prostate cancer oncogenetics, diagnostic and prognostic assessments increasingly rely on personalized approaches, including Comprehensive Genomic Profiling (CGP). In this pilot study, we aimed to establish optimal pre-analytical and analytical conditions for selected genetic diagnostic methods using tissue samples acquired through multiparametric MRI-guided biopsy. Tissue specimens from thirteen patients were processed for DNA isolation, fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS). Comparative analyses were performed on DNA derived from both fresh and formalin-fixed, paraffin-embedded (FFPE) samples. Sequencing quality metrics demonstrated markedly superior performance in fresh tissue compared to FFPE. These results highlight the importance of standardized tissue collection and processing protocols to enable reliable molecular diagnostics in prostate cancer. Our findings support the feasibility of integrating high-quality genomic testing into routine biopsy workflows and emphasize the need for further large-scale validation. Full article
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