Updates and Advances in the Field of Glioblastomas: Mechanisms, Microenvironment and Treatments

Dear Colleagues,

Despite the many years of effort and research spent searching for new clinical approaches and markers for treating glioblastoma multiforme (GBM), this tumor still remains one of the most common primary malignancies. However, recent years have seen major changes in classification, combined with the increased importance of precise molecular characterization. Significant advances have been reported in the taxonomy, classification, and grading of both adult and pediatric brain gliomas. In addition, the roles of the microenvironment, gene profiling, and molecular research are being further studied to ensure precise diagnoses and identify new treatments. This Special Issue aims to clarify the importance of molecular heterogeneity in GBM, both in adults and children, and to bridge mechanistic discoveries with translational innovation.

We welcome submissions, including original papers and reviews. Since IJMS is a journal of molecular science, pure clinical or model studies are not suitable. However, clinical or pure model submissions with biomolecular experiments are welcome. Our Special Issue will focus on, but is not restricted to, the following:

• Tumor signatures in primary vs. secondary gliomas;
• The role of recently identified biomarkers in both the prognosis and treatment of pediatric and adult gliomas;
• Role of checkpoints inhibitors in low- and high-grade gliomas;
• Mechanisms of recurrence of high-grade gliomas;
• Molecular features in low-grade gliomas shifting into high-grade gliomas.

Dr. Samantha Epistolio
Guest Editor

Manuscript Submission Information

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