Updates and Advances in the Field of Glioblastomas: Mechanisms, Microenvironment and Treatments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 995
Special Issue Editor
Special Issue Information
Dear Colleagues,
Despite the many years of effort and research spent searching for new clinical approaches and markers for treating glioblastoma multiforme (GBM), this tumor still remains one of the most common primary malignancies. However, recent years have seen major changes in classification, combined with the increased importance of precise molecular characterization. Significant advances have been reported in the taxonomy, classification, and grading of both adult and pediatric brain gliomas. In addition, the roles of the microenvironment, gene profiling, and molecular research are being further studied to ensure precise diagnoses and identify new treatments. This Special Issue aims to clarify the importance of molecular heterogeneity in GBM, both in adults and children, and to bridge mechanistic discoveries with translational innovation.
We welcome submissions, including original papers and reviews. Since IJMS is a journal of molecular science, pure clinical or model studies are not suitable. However, clinical or pure model submissions with biomolecular experiments are welcome. Our Special Issue will focus on, but is not restricted to, the following:
- Tumor signatures in primary vs. secondary gliomas;
- The role of recently identified biomarkers in both the prognosis and treatment of pediatric and adult gliomas;
- Role of checkpoints inhibitors in low- and high-grade gliomas;
- Mechanisms of recurrence of high-grade gliomas;
- Molecular features in low-grade gliomas shifting into high-grade gliomas.
Dr. Samantha Epistolio
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- GBM
- molecular classification
- pediatric diffuse gliomas
- signaling pathways in GBMs
- recurrent gliomas
- midbrain gliomas
- immunotherapy
- targeted therapies for GBMs
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