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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2001 | Submission Open

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

The Role and Mechanisms of Natural Products in Inflammatory Responses and Inflammatory Diseases

edited by

Young-Su Yi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1588 | Submission Open

Keywords: natural product; bioactive component; inflammation; inflammatory disease; anti-inflammatory; mechanism

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Inborn Errors of Immunity

edited by Aleksandra Szczawińska-Popłonyk

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1446 | Submission Open

Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Signalling Pathways in Metabolic Diseases and Cancers

edited by

Sabrina Bossio

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1394 | Submission Open

Keywords: cancer; prostate cancer; molecular signalling pathway; metabolic diseases; diabets; immunotherapy; immunological diseases

(This special issue belongs to the Section Biochemistry)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1281 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into the Environmental Toxicity of Contaminants and Risk Mitigation Strategies

edited by

Barbara Mognetti

and

Tiziana Cappello

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1160 | Submission Open

Keywords: microplastic toxicity; environmental pollutants; molecular mechanisms; cell metabolic pathways; in vivo; in vitro; and in silico models; pollutant interactions; risk mitigation strategies

(This special issue belongs to the Section Molecular Toxicology)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1041 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cotton Molecular Genomics and Genetics (Third Edition)

edited by

Jie Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 951 | Submission Open

Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into the Obstetrics and Gynecology

edited by

Gaspare Cucinella

submission deadline 20 Mar 2026 | Viewed by 816 | Submission Open

Keywords: ginecology; pelvic disorders; endometrial; cervical and ovarian cancers; covid and pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 20 Mar 2026 | 1 articles | Viewed by 639 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Autophagy and Programmed Cell Death in Plants and Algae

edited by

Sławomir Borek

submission deadline 20 Mar 2026 | Viewed by 461 | Submission Open

Keywords: algal autophagy and PCD; autophagy-related (Atg) genes and proteins; biotic and abiotic stresses; caspase-like proteases; crop plant improvement; macro-; micro-; and mega-autophagy; metacaspases; selective autophagy; signaling; vacuolar processing enzymes (VPEs)

(This special issue belongs to the Section Molecular Plant Sciences)

Roles of Neutrophils in Autoimmune Diseases and Cancers

edited by

Jasmin Knopf

submission deadline 20 Mar 2026 | Viewed by 320 | Submission Open

Keywords: neutrophils; neutrophil extracellular traps (NETs); autoimmunity; autoimmune disease(s); cancer; oncology

(This special issue belongs to the Section Molecular Immunology)

Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes

edited by Maria Victoria Preciado

submission deadline 20 Mar 2026 | Viewed by 221 | Submission Open

Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics

(This special issue belongs to the Section Molecular Immunology)

Pediatric Gastrointestinal and Biliary Diseases: From Molecular Basis to Therapy

edited by

Consolato M. Sergi

submission deadline 20 Mar 2026 | Viewed by 203 | Submission Open

Keywords: pediatrics; gastroenterology; biliary; therapy; genetics; biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Tolerance Mechanisms in Plants Under Stress

edited by

Lujun Yu

submission deadline 20 Mar 2026 | Viewed by 162 | Submission Open

Keywords: stress; tolerance; gene family; phytohormones; mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 20 Mar 2026 | Viewed by 118 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

Arthritis: From Molecular Basis to Therapy

edited by Cinzia Rotondo

submission deadline 20 Mar 2026 | Viewed by 47 | Submission Open

Keywords: comorbidities; biomarkers; inflammation; autoimmune disease; systemic disease; arthritis; autoimmune disease; psoriasis; axial involvement; biological drugs; target synthetic DMARDs; pathogenesis; rheumatoid arthritis; spondyloarthritis; psoriatic arthritis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Materials in Photocatalysis: From Design to Application

edited by

Miguel Díaz-Sánchez

submission deadline 20 Mar 2026 | Viewed by 34 | Submission Open

Keywords: nanostructured materials ; photocatalysis ; catalysis ; green synthesis ; material design ; surface engineering

(This special issue belongs to the Section Materials Science)

Genetic Diversity, Founder Effects, and Migration in Neurodegeneration: Molecular and Population Perspectives

edited by

Dasiel Oscar Borroto-Escuela

submission deadline 20 Mar 2026 | Viewed by 20 | Submission Open

Keywords: neurodegeneration; population genetics; founder effects; genetic diversity; migration and disease risk; spinocerebellar ataxia; Alzheimer’ s disease; Parkinson’ s disease; genetic epidemiology; underrepresented populations

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Engineering of Antimicrobial Agents: From Structure-Function Insights to Combinatorial Therapies

edited by Mingrui Liao

submission deadline 25 Mar 2026 | Viewed by 30 | Submission Open

Keywords: antimicrobial amphiphiles; antimicrobial resistance; structure– activity relationship; synergistic antimicrobial therapy; drug delivery systems

(This special issue belongs to the Section Molecular Biology)

Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy

edited by

Wei Dai

submission deadline 25 Mar 2026 | Viewed by 21 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); epstein– barr virus (EBV); cancer epigenomics; virus– host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives

edited by

Clemente Capasso

and

Valeria Pittalà

submission deadline 30 Mar 2026 | 5 articles | Viewed by 6712 | Submission Open

Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications

(This special issue belongs to the Section Biochemistry)

Immune Microenvironment and Tissue Remodeling in Oral Diseases and Oral Cancer

edited by

Aiman Ali

submission deadline 30 Mar 2026 | Viewed by 34 | Submission Open

Keywords: immune microenvironment; oral cancer; oral diseases; tissue remodeling; molecular signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Unravelling the Intricate Link Between Microvascular Dysfunction and Cardiovascular Disease

edited by Róbert Pórszász

submission deadline 31 Mar 2026 | 1 articles | Viewed by 746 | Submission Open

Keywords: microvascular dysfunction; cardiovascular pathogenesis; endothelial dysfunction; oxidative stress; nitric oxide bioavailability; VEGF dysregulation; endothelin-1 overactivity; heart failure with preserved ejection fraction (HFpEF); pharmacological interventions; microcirculation-targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanism Research on Listeria monocytogenes and Its Control

edited by

Irene Martín Tornero

submission deadline 31 Mar 2026 | Viewed by 206 | Submission Open

Keywords: Listeria monocytogenes; virulence; biofilm; pathogenicity; control; prevention; food safety

(This special issue belongs to the Section Molecular Microbiology)

ROS and Abiotic Stress in Plants, 3rd Edition

edited by

Tsanko S. Gechev

and

Veselin Petrov

submission deadline 31 Mar 2026 | Viewed by 33 | Submission Open

Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity

(This special issue belongs to the Section Molecular Plant Sciences)

Metabolic–Epigenetic Interplay in Healthy and Diseases

edited by

Ana Paula De Souza

submission deadline 31 Mar 2026 | Viewed by 30 | Submission Open

Keywords: epigenetics; metabolism; TCA cycle; one-carbon cycle; aging; longevity; cancer; metabolic syndrome; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Oxidative Stress and Glutathione Content in Liver Diseases: Innovative Signaling Pathways and Molecular Mechanisms

edited by

Mariapia Vairetti

Andrea Ferrigno

and

Giuseppe Colucci

submission deadline 31 Mar 2026 | Viewed by 10 | Submission Open

Keywords: oxidative stress; glutathione; MASLD; MASH; hepatic infections

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Crops: From Physiology to Breeding

edited by

Guang Chen

and Edyta Zdunek-Zastocka

submission deadline 31 Mar 2026 | Viewed by 3 | Submission Open

Keywords: crops; stress; cultivation measures; molecular mechanisms; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Neural Stem Cells as Tools for Therapies: Challenges and Future Perspectives

edited by

Daniele Bottai

submission deadline 31 Mar 2026 | Viewed by 1 | Submission Open

Keywords: spinal cord injury; spinal muscular atrophy; amyotrophic lateral sclerosis; neurological diseases; neural stem cell differentiation; cellular models; transplantation; trophic factor release

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Advances in Ear Diseases

edited by

András Molnár

submission deadline 31 Mar 2026 | Submission Open

Keywords: vertigo; hearing loss; tinnitus; otosclerosis; Mé niè re’ s disease; middle ear; inner ear; drug therapies; laboratory findings; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition

edited by

George J. Dugbartey

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8994 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies

edited by

Elena Tarca

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6575 | Submission Open

Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into Immune Dysregulation Disorders

edited by

Francesco Saettini

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6235 | Submission Open

Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders

(This special issue belongs to the Section Molecular Immunology)

Protein Folding, Misfolding, and Related Diseases

edited by

Ludmilla Morozova-Roche

submission deadline 20 Apr 2026 | 1 articles | Viewed by 3070 | Submission Open

Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental and Reproductive Toxicology

edited by

Hyun-Jung Park

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2816 | Submission Open

Keywords: spermatogenesis; mouse models; reproduction biology; assisted reproductive technology; cell signaling; cellular biology; developmental biology

(This special issue belongs to the Section Molecular Biology)

Stem Cells in Health and Disease: 3rd Edition

edited by

Maja Ludvigsen

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2723 | Submission Open

Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity

(This special issue belongs to the Section Molecular Biology)

Interplay of Metabolism and Inflammation in Gastrointestinal Disease

edited by Marios Papadakis and

Stavros P. Papadakos

submission deadline 20 Apr 2026 | Viewed by 1447 | Submission Open

Keywords: gastrointestinal diseases; inflammation; metabolic dysregulation; metabolic processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Techniques and Strategies in Drug Design and Discovery, 3rd Edition

edited by

George Mihai Nitulescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1245 | Submission Open

Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design

(This special issue belongs to the Section Molecular Pharmacology)

Synthetic Chemistry in Drug Discovery

edited by Kathiravan Suppan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 999 | Submission Open

Keywords: late-stage functionalization; AI-driven synthesis; drug discovery; synthetic chemistry; transition metal catalysis

(This special issue belongs to the Section Molecular Pharmacology)

Inflammatory Bowel Disease: Pathogenesis and Novel Therapeutic Approaches

edited by Francisco Giner

submission deadline 20 Apr 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: coeliac disease; microscopic colitis; Crohn’ s disease; ulcerative colitis; microbiota; biological therapies; refractory disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress of Orthopedic Materials

edited by Robert Karpiński

submission deadline 20 Apr 2026 | Viewed by 301 | Submission Open

Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings

(This special issue belongs to the Section Materials Science)

Investigating Gut Axes: Pathophysiological Functions and Therapeutic Strategies

edited by

Alessio Ardizzone

and

Sarah Adriana Scuderi

submission deadline 20 Apr 2026 | Viewed by 152 | Submission Open

Keywords: gut– brain axis; gut– heart axis; gut– liver axis; neurological diseases; cancer; novel and alternative therapies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery

edited by

Adelina-Gabriela Niculescu

and

Alexandra Catalina Birca

submission deadline 20 Apr 2026 | Viewed by 125 | Submission Open

Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Ophthalmic Diseases

edited by

Alicja Forma

submission deadline 27 Apr 2026 | Viewed by 15 | Submission Open

Keywords: environmental hazards; ophthalmic diseases; molecular mechanisms; risk factors; disease prevention; oxidative stress; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advance in Nutraceutical Research: From Bioactive Discovery to Translational Application

edited by

Alessandro Colletti

submission deadline 27 Apr 2026 | Viewed by 9 | Submission Open

Keywords: bioactive compounds; nutraceuticals; molecular mechanisms; nutraceutical formulations; preclinical and clinical validation; targeted delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Toxicity: Identifying Biomarkers and Molecular Pathways Involved in Toxicological Responses

edited by Irma Martha Medina Díaz

submission deadline 29 Apr 2026 | Viewed by 248 | Submission Open

Keywords: biomarkers; molecular pathways; chemical exposure assessment; environmental exposure; human health; public health toxicology

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Cardiac Development and Disease (Second Edition)

edited by

Kay-Dietrich Wagner

submission deadline 29 Apr 2026 | Viewed by 6 | Submission Open

Keywords: cardiac development; cardiac repair; regeneration; cardiac cell-cell interaction; fibrosis; remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights and Therapeutic Innovations in Neuromuscular Diseases

edited by

Virginia Arechavala Gomeza

submission deadline 30 Apr 2026 | Viewed by 5 | Submission Open

Keywords: neuromuscular disorders; molecular mechanisms; gene therapies; RNA therapies; small molecules

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 30 Apr 2026 | Viewed by 5 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3301-3350 on page 67 of 68.

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