25th Anniversary of IJMS: Updates and Advances in Molecular Pharmacology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 5
Special Issue Editor
Interests: cancer; biomarkers; mitochondria; targeted drugs; clinical chemistry; laboratory medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The field of molecular pharmacology is rapidly transforming, driven by innovative technologies that reshape our understanding of drug-target interactions and push towards novel therapeutic approaches. We are entering a new era of pharmacology, moving beyond traditional small-molecule inhibitors/activators. New techniques (i.e., cryo-electron microscopy -Cryo-EM-) permit atomic-level visualization of drug binding to biological components as proteins, ameliorating drug design. Moreover, the introduction of 'omics' technologies—genomics, proteomics, and transcriptomics—is advancing pharmacogenomics, allowing precise predictions of drug responses and toxicities for individuals (i.e., personelized pharmacology).
Most importantly, the therapeutic landscape is evolving with new drug modalities derived from genetic approaches. RNA-based therapeutics, including siRNA, ASO, and mRNA, allow for direct modulation of gene expression in previously “undruggable” pathways. Breakthroughs in targeted protein degradation through PROTACs and “molecular glues” enable the elimination of toxic proteins. At last but not least, the integration of these biological advances with artificial intelligence will accelerate the drug discovery pipeline. These advancements represent a fundamental steps towards a more specific, personalized, and effective treatments for various human diseases.
Prof. Dr. Roberto Scatena
Guest Editor
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Keywords
- precision medicine
- pharmacogenomics
- targeted protein degradation (TPD)
- molecular pharmacology
- RNA Therapeutics
- novel drug modalities
- proteomics
- transcriptomics
- personalized drug therapy
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