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Advances in Photobiomodulation Therapy
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Advances in Photobiomodulation Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 572

Special Issue Editor

Dr. Maria Fernanda Setúbal Destro Rodrigues

E-Mail Website
Guest Editor
Postgraduate Program in Biophotonics Applied to the Health Sciences, Universidade Nove de Julho (UNINOVE), Sao Paulo 01525-000, SP, Brazil
Interests: photobiomodulation; oral squamous cell carcinoma; molecular and cellular biology; cancer-associated fibroblasts; photodynamic therapy

Special Issue Information

Dear Colleagues,

The International Journal of Molecular Sciences invites submissions for a Special Issue on "Advances in Photobiomodulation Therapy". We encourage researchers to contribute both preclinical and clinical studies that investigate the molecular mechanisms, therapeutic applications, and clinical outcomes of photobiomodulation (PBM) in different human diseases. PBM has emerged as a promising non-invasive treatment modality, with growing evidence supporting its efficacy in pain management, wound healing, lung diseases, neurological disorders, and musculoskeletal rehabilitation. This Special Issue aims to provide a comprehensive platform for the latest advancements in PBM, exploring novel approaches, dose–response relationships, and translational research from bench to bedside. We invite you to share your cutting-edge findings and contribute to shaping the future of PBM in clinical practice. Submit your manuscript to help drive the progress in this rapidly expanding field.

Dr. Maria Fernanda Setúbal Destro Rodrigues
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photobiomodulation
  • dosimetric parameters
  • human diseases
  • modulation of inflammation
  • photobiomodulation therapy
  • molecular mechanisms
  • preclinical and clinical studies
  • therapeutic applications of PBM

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Published Papers (2 papers)

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Research

14 pages, 6123 KiB  
Article
Effects of Near-Infrared Diode Laser Irradiation on Pain Relief and Neuropeptide Markers During Experimental Tooth Movement in the Periodontal Ligament Tissues of Rats: A Pilot Study
by Kanako Okazaki, Ayaka Nakatani, Ryo Kunimatsu, Isamu Kado, Shuzo Sakata, Hirotaka Kiridoshi and Kotaro Tanimoto
Int. J. Mol. Sci. 2025, 26(15), 7404; https://doi.org/10.3390/ijms26157404 (registering DOI) - 31 Jul 2025
Abstract
Pain following orthodontic treatment is the chief complaint of patients undergoing this form of treatment. Although the use of diode lasers has been suggested for pain reduction, the mechanism of laser-induced analgesic effects remains unclear. Neuropeptides, such as substance P (SP) and calcitonin [...] Read more.
Pain following orthodontic treatment is the chief complaint of patients undergoing this form of treatment. Although the use of diode lasers has been suggested for pain reduction, the mechanism of laser-induced analgesic effects remains unclear. Neuropeptides, such as substance P (SP) and calcitonin gene-related peptide (CGRP), contribute to the transmission and maintenance of inflammatory pain. Heat shock protein (HSP) 70 plays a protective role against various stresses, including orthodontic forces. This study aimed to examine the effects of diode laser irradiation on neuropeptides and HSP 70 expression in periodontal tissues induced by experimental tooth movement (ETM). For inducing ETM for 24 h, 50 g of orthodontic force was applied using a nickel–titanium closed-coil spring to the upper left first molar and the incisors of 20 male Sprague Dawley rats (7 weeks old). The right side without ETM treatment was considered the untreated control group. In 10 rats, diode laser irradiation was performed on the buccal and palatal sides of the first molar for 90 s with a total energy of 100.8 J/cm2. A near-infrared (NIR) laser with a 808 nm wavelength, 7 W peak power, 560 W average power, and 20 ms pulse width was used for the experiment. We measured the number of facial groomings and vacuous chewing movements (VCMs) in the ETM and ETM + laser groups. Immunohistochemical staining of the periodontal tissue with SP, CGRP, and HSP 70 was performed. The number of facial grooming and VCM periods significantly decreased in the ETM + laser group compared to the ETM group. Moreover, the ETM + laser group demonstrated significant suppression of SP, CGRP, and HSP 70 expression. These results suggest that the diode laser demonstrated analgesic effects on ETM-induced pain by inhibiting SP and CGRP expression, and decreased HSP 70 expression shows alleviation of cell damage. Thus, although further validation is warranted for human applications, an NIR diode laser can be used for reducing pain and neuropeptide markers during orthodontic tooth movement. Full article
(This article belongs to the Special Issue Advances in Photobiomodulation Therapy)
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21 pages, 6233 KiB  
Article
Multispectral Pulsed Photobiomodulation Enhances Diabetic Wound Healing via Focal Adhesion-Mediated Cell Migration and Extracellular Matrix Remodeling
by Jihye Choi, Myung Jin Ban, Chan Hee Gil, Sung Sik Hur, Laurensia Danis Anggradita, Min-Kyu Kim, Ji Won Son, Jung Eun Kim and Yongsung Hwang
Int. J. Mol. Sci. 2025, 26(13), 6232; https://doi.org/10.3390/ijms26136232 - 27 Jun 2025
Viewed by 436
Abstract
Chronic diabetic wounds affect 15–20% of patients and are characterized by impaired healing due to disrupted hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Low-level light therapy (LLLT) has emerged as a promising noninvasive strategy for enhancing tissue regeneration. Here, we developed a [...] Read more.
Chronic diabetic wounds affect 15–20% of patients and are characterized by impaired healing due to disrupted hemostasis, inflammation, proliferation, and extracellular matrix (ECM) remodeling. Low-level light therapy (LLLT) has emerged as a promising noninvasive strategy for enhancing tissue regeneration. Here, we developed a multispectral pulsed LED system combining red and near-infrared light to stimulate wound healing. In vitro photostimulation of human keratinocytes and fibroblasts on biomimetic hydrogels enhanced adhesion, spreading, migration, and proliferation via increased focal adhesion kinase (pFAK), paxillin, and F-actin expression. In vivo, daily LED treatment of streptozotocin-induced diabetic wounds accelerated closure and improved ECM remodeling. Histological and molecular analyses revealed elevated levels of MMPs, interleukins, collagen, fibronectin, FGF2, and TGF-β1, supporting regenerative healing without excessive fibrosis. These findings demonstrate that multispectral pulsed photobiomodulation enhances diabetic wound healing through focal adhesion-mediated cell migration and ECM remodeling, offering a cost-effective and clinically translatable approach for chronic wound therapy. Full article
(This article belongs to the Special Issue Advances in Photobiomodulation Therapy)
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