Hypoxia: Molecular Mechanism and Health Effects
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 1534
Special Issue Editor
Interests: non-coding RNAs; molecular oncology; tumour microenvironment; Wnt signalling; prostate cancer; breast cancer; pancreatic ductal adenocarcinoma
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Special Issue Information
Dear Colleagues,
Hypoxia, a condition characterized by reduced oxygen availability, has a critical role in various physiological and pathological processes. It is a key factor in the progression of diseases such as cancer, cardiovascular disorders, neurodegenerative diseases, and chronic inflammatory conditions. At the cellular level, hypoxia triggers complex molecular mechanisms involving hypoxia-inducible factors (HIFs), oxidative stress, mitochondrial dysfunction, and metabolic reprogramming, which collectively influence cell survival, proliferation, and adaptation.
This Special Issue, "Hypoxia: Molecular Mechanism and Health Effects", aims to bring together cutting-edge research that explores the intricate molecular pathways activated by hypoxia and their implications for health and disease. We welcome submissions that investigate the cellular responses to hypoxia, the role of hypoxia in disease pathogenesis, and potential therapeutic strategies to mitigate hypoxia-induced damage. Studies focusing on the crosstalk between hypoxia and other signalling pathways, the role of hypoxia in tissue regeneration, and the development of novel hypoxia-targeted therapies are particularly encouraged.
The aim of this Special Issue is to evaluate the current advances in hypoxia research, offering insights into the molecular underpinnings of hypoxia-related diseases and paving the way for the development of innovative therapeutic approaches. We invite researchers from diverse fields, including molecular biology, biochemistry, and pharmacology, to contribute original research articles, reviews, and perspectives that enhance our understanding of hypoxia and its wide-ranging impacts on human health.
Dr. Pinar Uysal-Onganer
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- hypoxia
- inflammation
- oxidative stress
- metabolic conditions
- hypoxia-inducible factors (HIFs)
- oxidative stress
- mitochondrial dysfunction
- angiogenesis
- metabolic reprogramming
- apoptosis
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