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Hypoxia: Molecular Mechanism and Health Effects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1534

Special Issue Editor

Special Issue Information

Dear Colleagues,

Hypoxia, a condition characterized by reduced oxygen availability, has a critical role in various physiological and pathological processes. It is a key factor in the progression of diseases such as cancer, cardiovascular disorders, neurodegenerative diseases, and chronic inflammatory conditions. At the cellular level, hypoxia triggers complex molecular mechanisms involving hypoxia-inducible factors (HIFs), oxidative stress, mitochondrial dysfunction, and metabolic reprogramming, which collectively influence cell survival, proliferation, and adaptation.

This Special Issue, "Hypoxia: Molecular Mechanism and Health Effects", aims to bring together cutting-edge research that explores the intricate molecular pathways activated by hypoxia and their implications for health and disease. We welcome submissions that investigate the cellular responses to hypoxia, the role of hypoxia in disease pathogenesis, and potential therapeutic strategies to mitigate hypoxia-induced damage. Studies focusing on the crosstalk between hypoxia and other signalling pathways, the role of hypoxia in tissue regeneration, and the development of novel hypoxia-targeted therapies are particularly encouraged.

The aim of this Special Issue is to evaluate the current advances in hypoxia research, offering insights into the molecular underpinnings of hypoxia-related diseases and paving the way for the development of innovative therapeutic approaches. We invite researchers from diverse fields, including molecular biology, biochemistry, and pharmacology, to contribute original research articles, reviews, and perspectives that enhance our understanding of hypoxia and its wide-ranging impacts on human health.

Dr. Pinar Uysal-Onganer
Guest Editor

Manuscript Submission Information

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Keywords

  • hypoxia
  • inflammation
  • oxidative stress
  • metabolic conditions
  • hypoxia-inducible factors (HIFs)
  • oxidative stress
  • mitochondrial dysfunction
  • angiogenesis
  • metabolic reprogramming
  • apoptosis

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Published Papers (1 paper)

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Research

22 pages, 14854 KiB  
Article
Multiomics Analysis Reveals Role of ncRNA in Hypoxia of Mouse Brain Microvascular Endothelial Cells
by Qixin Shi, Shuai Zhang, Shaohua Li, Bin Zhang, Jin Xu, Yun-Gang Bai, Man-Jiang Xie and Jin Ma
Int. J. Mol. Sci. 2025, 26(12), 5629; https://doi.org/10.3390/ijms26125629 - 12 Jun 2025
Viewed by 297
Abstract
Hypoxia leads to endothelial dysfunction and increased blood–brain barrier (BBB) permeability, promoting the incidence of diseases such as stroke and acute high-altitude illness. Brain microvascular endothelial cells (BMECs) are important structural and functional components of the BBB; however, the molecular changes that occur [...] Read more.
Hypoxia leads to endothelial dysfunction and increased blood–brain barrier (BBB) permeability, promoting the incidence of diseases such as stroke and acute high-altitude illness. Brain microvascular endothelial cells (BMECs) are important structural and functional components of the BBB; however, the molecular changes that occur in BMECs during hypoxia remain unknown. We reported the molecular and functional changes in BMECs under hypoxia through whole-transcriptome sequencing, small RNA microarray, TMT quantitative proteomic, and untargeted metabolomic analyses. We found that hypoxia affected pathways such as ncRNA processing, the HIF-1 signaling pathway, the cell cycle, DNA replication, glucose metabolism, protein synthesis, and inflammation pathways. ncRNA processing was significantly downregulated. However, the levels of some miRNAs, tRNAs, tsRNAs, snoRNAs, lncRNAs, and circRNAs were significantly upregulated under hypoxia. These results suggest that ncRNAs may play an important role in oxidative stress and cellular adaptation to hypoxia, helping us understand the pathological process of BBB injury and providing potential targets for the treatment of BBB-related cerebrovascular diseases. Full article
(This article belongs to the Special Issue Hypoxia: Molecular Mechanism and Health Effects)
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