Platelets at the Intersection of Atherosclerosis Processes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 1831
Special Issue Editor
Interests: dental biochemistry; oxidative stress in systemic and oral diseases; salivary biomarkers; AKT/mTOR signaling pathway; molecular and biochemical aspects in burns
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Special Issue Information
Dear Colleagues,
Atherosclerosis begins with injury to the endothelium caused by factors such as high blood pressure, diabetes, smoking, and high levels of LDL cholesterol. Platelets react by attaching to the injured endothelium, releasing chemokines and adhesion molecules which activate immune cells and intensify inflammation. This interaction attracts immune cells to form plaques, especially in areas of shear stress, where proteins like platelet–endothelial cell adhesion molecule-1 (PECAM-1) strengthen the adhesion between platelets and endothelial cells. Additionally, platelets contribute to inflammation by forming aggregates with leukocytes and increasing vascular permeability. Platelets serve as key players in the complex interplay of factors that drives atherosclerosis, making them a critical target for therapeutic strategies aimed at reducing cardiovascular risk.
This Special Issue is supervised by Prof. Dr. Maria Greabu and assisted by our Topical Advisory Panel Member Dr. Bogdana Virgolici (University of Medicine and Pharmacy).
Prof. Dr. Maria Greabu
Guest Editor
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Keywords
- platelets
- inflammation
- atherosclerosis
- endothelial cells
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