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25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1168

Special Issue Editor

Special Issue Information

Dear Colleagues,

To celebrate the 25th anniversary of IJMS, this Special Issue highlights recent advances in molecular endocrinology and metabolism, including both classical and emerging topics. The collection features high-quality research and review articles covering hormonal regulation, metabolic diseases, neuroendocrinology, endocrine-related cancers, and aging, among other topics.

We also spotlight innovative technologies transforming the field, such as omics approaches, systems biology, and AI-driven analyses. We invite original and cross-disciplinary contributions that help unravel the complexity of endocrine systems and metabolic networks, and advance our understanding of human and comparative endocrinology.

Topics include, but are not limited to, the following:

  • Endocrine systems and endocrine-related diseases.
  • Molecular, cellular, genetic, epigenetic, and developmental approaches.
  • Animal models in endocrine and metabolic research.
  • Novel insights into physiology, pathophysiology, and therapeutic strategies.
  • Neuroendocrinology and neuroendocrine control of endocrine axes.
  • Classical glands: thyroid, adrenal, pituitary, parathyroid, testis, ovary, etc.
  • Non-classical endocrine systems: gut, bone, liver, etc.
  • Lipid and bone metabolism.
  • Hormones, paracrine factors, receptors, and binding proteins.
  • Nuclear and membrane hormone receptors and intracellular signaling pathways.
  • Steroid biosynthesis and metabolism of hormones and neurotransmitters.
  • Cellular interactions and regulatory factors in endocrine tissues.
  • Energy balance and expenditure.
  • Diabetes and insulin resistance.
  • Infertility and reproductive diseases.
  • Obesity and metabolic syndrome.
  • Osteoporosis and musculoskeletal endocrinology.
  • Aging and endocrine changes over the lifespan.
  • Endocrine-related tumors and cancers.
  • Endocrine-disrupting chemicals and environmental exposures.
  • Crossdisciplinary and integrative studies.
  • Comparative endocrinology.
  • Omics-based approaches (genomics, transcriptomics, proteomics, metabolomics, and lipidomics).
  • Systems biology and computational modeling of endocrine networks.
  • Artificial intelligence and machine learning in endocrine and metabolic research.
  • Microbiome–endocrine interactions.
  • Chronobiology and circadian regulation of hormonal systems.
  • Personalized and precision medicine in endocrinology.
  • Single-cell technologies and spatial transcriptomics applied to endocrine tissues.

Dr. José L. Quiles
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular endocrinology
  • metabolic diseases
  • hormonal regulation
  • systems biology
  • precision medicine

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Published Papers (1 paper)

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Review

31 pages, 1732 KB  
Review
GLUT4 Trafficking and Storage Vesicles: Molecular Architecture, Regulatory Networks, and Their Disruption in Insulin Resistance
by Hana Drobiova, Ghadeer Alhamar, Rasheed Ahmad, Fahd Al-Mulla and Ashraf Al Madhoun
Int. J. Mol. Sci. 2025, 26(15), 7568; https://doi.org/10.3390/ijms26157568 - 5 Aug 2025
Viewed by 1001
Abstract
Insulin-regulated glucose uptake is a central mechanism in maintaining systemic glucose homeostasis, primarily occurring in skeletal muscle and adipose tissue. This process relies on the insulin-stimulated translocation of the glucose transporter, GLUT4, from specialized intracellular compartments, known as GLUT4 storage vesicles (GSVs), to [...] Read more.
Insulin-regulated glucose uptake is a central mechanism in maintaining systemic glucose homeostasis, primarily occurring in skeletal muscle and adipose tissue. This process relies on the insulin-stimulated translocation of the glucose transporter, GLUT4, from specialized intracellular compartments, known as GLUT4 storage vesicles (GSVs), to the plasma membrane. Disruption of this pathway is a hallmark of insulin resistance and a key contributor to the pathogenesis of type 2 diabetes. Recent advances have provided critical insights into both the insulin signalling cascades and the complex biogenesis, as well as the trafficking and fusion dynamics of GSVs. This review synthesizes the current understanding of the molecular mechanisms governing GSV mobilization and membrane fusion, highlighting key regulatory nodes that may become dysfunctional in metabolic disease. By elucidating these pathways, we propose new therapeutic avenues targeting GSV trafficking to improve insulin sensitivity and combat type 2 diabetes. Full article
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