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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Analysis on Effector and Regulatory Molecules in Renal Diseases
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1176 | Submission Open
Keywords: effector molecules; regulatory molecules; membrane attack complex (MAC); perforin; granzyme; immune complex; neutrophil extracellular traps (NETs); proteolytic enzymes; reactive oxygen species; infection-related glomerulonephritis (IRGN); nephritis-associated plasmin receptor (NAPlr); streptococcal pyrogenic exotoxin B (SPEB); adhesion molecules
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications
edited by and Hiu Yee Kwan
submission deadline 20 May 2026 | 1 articles | Viewed by 1063 | Submission Open
Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application
(This special issue belongs to the Section Molecular Oncology)
New Molecular Insights into Antibacterial Materials
edited by Rahela Carpa
submission deadline 20 May 2026 | 1 articles | Viewed by 1034 | Submission Open
Keywords: antimicrobial resistance; nanoparticles; biopolymers; antimicrobial peptides; antimicrobial materials
(This special issue belongs to the Section Materials Science)
Surfactants: Design, Synthesis and Application
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1020 | Submission Open
Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic– lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics
(This special issue belongs to the Section Materials Science)
The Role of Extracellular Vesicles in Disease and Therapeutic Applications
edited by Sunyoung Park
submission deadline 20 May 2026 | 1 articles | Viewed by 996 | Submission Open
Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Biological Study of Plant Bioactive Compounds submission deadline 20 May 2026 | 1 articles | Viewed by 938 | Submission Open
Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Current Research in Membrane Transporters, Channels, and Receptors
edited by Ivana Vrhovac Madunic
submission deadline 20 May 2026 | 1 articles | Viewed by 934 | Submission Open
Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging
(This special issue belongs to the Section Molecular Biology)
Emerging Roles of the Gut-Brain Axis (GBA) in Health and Disease
edited by Vinata Vedam-Mai
submission deadline 20 May 2026 | 1 articles | Viewed by 933 | Submission Open
Keywords: gut– brain axis; gut microbiota; brain function; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Aquatic Organisms Models Dedicated to Disease submission deadline 20 May 2026 | Viewed by 923 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Viral Pathogenesis: From Infection to Host Response
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 916 | Submission Open
Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation
(This special issue belongs to the Section Molecular Microbiology)
Synthesis and Application of Natural and Inspired-Natural Products
edited by Mauro de Nisco
submission deadline 20 May 2026 | 1 articles | Viewed by 914 | Submission Open
Keywords: natural products; natural substances; derivative; synthesis; application
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Intrinsically Disordered Proteins (IDPs): From Structure to Mechanism and Function
edited by
submission deadline 20 May 2026 | Viewed by 902 | Submission Open
Keywords: IDP; NMR; completely unstructured; pre-structured; PreSMo; target binding
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms of Environmental Stress-Induced Human Diseases
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 789 | Submission Open
Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Transcription Factors in Antioxidant Pathways
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 776 | Submission Open
Keywords: transcription factor; oxidative stress; NRF1/2; NRF3; NFkB; P53; antioxidant-response elements; neurologial diseases; metabolic diseases; cancer
(This special issue belongs to the Section Molecular Biology)
Unraveling the Molecular Landscape of Primary Brain Tumors
edited by , Francesco Pasqualetti and Tamara Ius
submission deadline 20 May 2026 | Viewed by 769 | Submission Open
Keywords: primary brain tumors; molecular oncology; glioma; glioblastoma; biomarkers; targeted therapy; epigenetics; tumor microenvironment; genomic profiling; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Primary Colorectal Cancer and Liver Metastases
edited by Alexandros E. Giakoustidis
submission deadline 20 May 2026 | 1 articles | Viewed by 749 | Submission Open
Keywords: colorectal cancer; metastasis; treatment; management; screening; genetic alterations; epigenetic alterations; genomics; epigenomics; methylation; liver-directed therapy; radiation; immunotherapy; peritoneal carcinomatosis; monotherapy; chemotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments submission deadline 20 May 2026 | Viewed by 731 | Submission Open
Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms
(This special issue belongs to the Section Molecular Biology)
Sarcomas: From Molecular Signatures to Morphologic Patterns
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 723 | Submission Open
Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Ocular Inflammation and Infection
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 697 | Submission Open
Keywords: ocular infections; uveitis; choroiditis; masquerade syndrome; pseudo-uveitis; intraocular lymphoma; retinal dystrophy; ocular inflammation; neuroinflammation; immunotherapy-induced uveitis; autoimmune eye diseases; sarcoidosis; OCT; indocyanine green angiography
(This special issue belongs to the Section Molecular Immunology)
Chessboard: How Plants and Insects Outsmart Each Other
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 679 | Submission Open
Keywords: acarology; biotic stress; entomology nitric oxide; oxidative stress; phytopathology; reactive nitrogen species; reactive oxygen species
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Skeletal Muscle Adaptation
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 653 | Submission Open
Keywords: skeletal muscle; adaptive responses; muscle physiology; genomics; transcriptomics; proteomics; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Computational Approaches in Biomedicine: Innovations and Insights
edited by
submission deadline 20 May 2026 | Viewed by 639 | Submission Open
Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery
(This special issue belongs to the Section Molecular Informatics)
Repair Mechanisms of Stem Cells submission deadline 20 May 2026 | Viewed by 627 | Submission Open
Keywords: stem cell biology; stem cells; stem cell therapy; tissue regeneration
(This special issue belongs to the Section Biochemistry)
Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease
edited by
submission deadline 20 May 2026 | Viewed by 623 | Submission Open
Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Biological Breeding and Molecular Biology of Tropical Crops
edited by Yongzan Wei
submission deadline 20 May 2026 | 1 articles | Viewed by 621 | Submission Open
Keywords: tropical crops; biological breeding; tropical fruit; molecular biology; gene editing; transcrip-tional regulation; genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Unraveling Neuroimmune Disorders: From Pathogenic Pathways to Biomarker-Driven Precision Medicine
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 591 | Submission Open
Keywords: innate immunity; adaptive immunity; inflammation; autoantibodies; peptides; cytokines; receptors; leukocytes; extracellular vesicles; signal transduction; apoptosis
(This special issue belongs to the Section Molecular Immunology)
Molecular Adaptation Mechanisms of Plants to Environmental Stress
edited by
submission deadline 20 May 2026 | Viewed by 577 | Submission Open
Keywords: signal perception; signal transduction; post-translational modifications; stress response genes; reactive oxygen species; osmoprotectant; antioxidants; plant hormones; stress-related proteins; climate change; biotic stress; abiotic stress
(This special issue belongs to the Section Molecular Plant Sciences)
Heart Failure and Cardiac Remodeling: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 May 2026 | Viewed by 576 | Submission Open
Keywords: heart failure; cardiac remodeling; molecular mechanisms; therapeutic strategies; cardiomyopathy; biomarkers; gene therapy; regenerative medicine; pharmacology; inflammation; fibrosis; signal transduction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Death in Human Diseases: Mechanisms, Biomarkers and Therapeutic Opportunities
edited by
submission deadline 20 May 2026 | Viewed by 554 | Submission Open
Keywords: cell death; apoptosis; necroptosis; ferroptosis; pyroptosis; human disease; biomarkers
(This special issue belongs to the Section Molecular Biology)
New Biomarkers in Pancreatic Diseases
edited by and
submission deadline 20 May 2026 | Viewed by 551 | Submission Open
Keywords: pancreatic disease; pancreatic cancer; pancreatitis; biomarker; RNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Fibrinolytic Factors in Disease
edited by
submission deadline 20 May 2026 | Viewed by 548 | Submission Open
Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1
(This special issue belongs to the Section Molecular Biology)
X-Linked Disorders: Epigenetic and Environmental Modulation of Phenotypes
edited by Yoram Chaiter and
submission deadline 20 May 2026 | Viewed by 537 | Submission Open
Keywords: X-linked disorders; epigenetics; environmental factors; gene expression; clinical manifestations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation
edited by Su-Yun Lyu
submission deadline 20 May 2026 | 1 articles | Viewed by 534 | Submission Open
Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential submission deadline 20 May 2026 | 1 articles | Viewed by 533 | Submission Open
Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination
(This special issue belongs to the Section Molecular Neurobiology)
The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 490 | Submission Open
Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in the Biological Function of Tyrosinase
edited by
submission deadline 20 May 2026 | Viewed by 478 | Submission Open
Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Potential New Antidepressant Drugs submission deadline 20 May 2026 | Viewed by 471 | Submission Open
Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Defects of Naturally Occurring Mutations
edited by Ya-Xiong Tao
submission deadline 20 May 2026 | Viewed by 458 | Submission Open
Keywords: protein misfolding; loss of function; gain of function; pharmacological chaperone; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Interfaces for the Impact of Magnetic Pulses or EMF in Molecular Biology
edited by Richard H. W. Funk
submission deadline 20 May 2026 | Viewed by 440 | Submission Open
Keywords: electromagnetic treatment; magnetic pulses; biological interface; cell biology; molecular biology; signaling cascades; clinical treatment; monitoring; sensors
(This special issue belongs to the Section Molecular Biophysics)
Antituberculous Drugs: Progress and Challenges
edited by Ana Maria Telmo Dias Pereira Vicente Cabral and
submission deadline 20 May 2026 | Viewed by 426 | Submission Open
Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Cardiomyopathy: From Molecular Pathology to Treatment submission deadline 20 May 2026 | Viewed by 424 | Submission Open
Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodeling; microRNAs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
mRNA/miRNAs Network in Diabetes and Its Complications
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 409 | Submission Open
Keywords: RNA/miRNAs; exosomes; regenerative medicine; translational medicine; adipose tissue biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Neurofibromatosis Type 1: From Molecular Insights to Novel Therapies
edited by László Szabó and
submission deadline 20 May 2026 | Viewed by 391 | Submission Open
Keywords: neurofibromatosis type 1; genotype– phenotype analyses; molecular pathogenesis; next-generation sequencing (NGS); molecular targeted therapy; MEK inhibitors; imaging studies
(This special issue belongs to the Section Molecular Neurobiology)
Pathogenesis and Treatment of Prostate Cancer submission deadline 20 May 2026 | Viewed by 390 | Submission Open
Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Understanding Respiratory Virus–Host Interactions
edited by Kun Li
submission deadline 20 May 2026 | Viewed by 365 | Submission Open
Keywords: respiratory viruses; virus– host interactions; molecular mechanisms; viral replication; host– immune response; molecular pathogenesis; molecular signaling; antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
Molecular Targets and Mechanisms of Innovative Therapies and Natural Adjuvants in Glioblastoma Management
edited by and Fabrizio De Luca
submission deadline 20 May 2026 | Viewed by 361 | Submission Open
Keywords: glioblastoma; targeted therapy; traditional and emerging therapies; signaling pathways; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Advanced Research in Nanophotonics and Biophotonics
edited by
submission deadline 20 May 2026 | Viewed by 359 | Submission Open
Keywords: biophotonics; spectroscopy; light scattering; Raman/FTIR; cancer; Alzheimer's and Parkinson’ s diseases; nanophotonics; plasmonics; nano-biophotonics
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Pharmacology of Cation-Permeable Ion Channels
edited by
submission deadline 20 May 2026 | Viewed by 358 | Submission Open
Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Antimicrobial Agents: Mechanisms and Applications submission deadline 20 May 2026 | Viewed by 350 | Submission Open
Keywords: antimicrobial compounds; antibacterial activity; antibiotic resistance; pathogen-tailored therapeutic targeting; novel antimicrobials; molecular aspects of the mechanisms of action of antibacterial substances; effectiveness of antibacterial substances
(This special issue belongs to the Section Biochemistry)
New Advances in Reproductive Immunology and Pathology
edited by Silvia Giugliano
submission deadline 20 May 2026 | Viewed by 346 | Submission Open
Keywords: maternal– fetal immune tolerance; reproductive immunopathology; cytokine signaling in pregnancy; immune-related infertility; metabolome-immune crosstalk; microbiome influence on fertility
(This special issue belongs to the Section Molecular Immunology)
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