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Advanced Research in Nanophotonics and Biophotonics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 1486

Special Issue Editor


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Guest Editor
Department of Physics and Astronomy, Mississippi State University, Starkville, MS 39762, USA
Interests: biophotonics; nanophotonics; random lasers; raman spectroscopy

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the recent advancements in nanophotonics and biophotonics and their different applications, including biological and biomedical research applications. We plan to cover various optical/photonics techniques, such as spectroscopy, microscopy, Raman, and FTIR, probing abnormalities in cells and tissues, ranging from cancer to brain diseases. Additionally, we are interested in topics in nanophononics, including plasmonics, nearfield optical microscopy, nano-lasers, nano-biophotonics, etc., and their applications to molecular biological/molecular biomedical research.

In this Special Issue, we invite researchers to submit original research articles on optical/photonics techniques, nanophononics, and nanophotonics, or reviews on the last developments in these fields. IJMS is a molecular journal and we hope that your paper contains as much molecular content as possible.

Dr. Prabhakar Pradhan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biophotonics
  • spectroscopy
  • light scattering
  • Raman/FTIR
  • cancer
  • Alzheimer's and Parkinson’s diseases
  • nanophotonics
  • plasmonics
  • nano-biophotonics

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Published Papers (1 paper)

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Research

20 pages, 5167 KB  
Article
Comprehensive Multimodal and Multiscale Analysis of Alzheimer’s Disease in 5xFAD Mice: Optical Spectroscopies, TEM, Neuropathological, and Behavioral Investigations
by Dhruvil Solanki, Ishmael Apachigawo, Sazzad Khan, Santanu Maity, Fatemah Alharthi, Samia Nasim, Fnu Sweety, Mohammad Alizadeh Poshtiri, Jianfeng Xiao, Mohammad Moshahid Khan and Prabhakar Pradhan
Int. J. Mol. Sci. 2026, 27(1), 198; https://doi.org/10.3390/ijms27010198 - 24 Dec 2025
Viewed by 962
Abstract
Alzheimer’s disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable biomarkers and developing effective therapies. In this [...] Read more.
Alzheimer’s disease (AD) is considered one of the leading causes of death in the United States, and there is no effective cure for it. Understanding the neuropathological mechanisms underlying AD is essential for identifying early, reliable biomarkers and developing effective therapies. In this paper, we report on a comprehensive multimodal study of AD pathology using the 5xFAD mouse model. We employed light-scattering techniques, Partial Wave Spectroscopy (PWS) and Inverse Participation Ratio (IPR), to detect nanoscale structural alterations in brain tissues, nuclear components, and mitochondria. To support the light-scattering experiments, behavior, and histopathological studies were conducted. These analyses revealed significant increases in structural heterogeneity and mass density fluctuations in the brains of 5xFAD mice compared with Non-transgenic controls. Behavioral assessment performed using the Novel Object Recognition test demonstrated memory impairment in 5xFAD mice, reflected by a reduced recognition index. Histopathological analysis further revealed increased amyloid beta plaques and microglia activation in the hippocampus and cortex of 5xFAD mice compared with Non-transgenic controls. An increase in structural disorder within brain tissues can be attributed to higher mass density fluctuations, likely arising from macromolecular rearrangement driven by amyloid beta aggregation and neuroinflammatory responses as the disease progresses. Our findings suggest that PWS and IPR-derived metrics provide sensitive biophysical indicators of early cellular and subcellular disruption, offering potential as quantitative biomarkers for the detection of AD. Full article
(This article belongs to the Special Issue Advanced Research in Nanophotonics and Biophotonics)
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