Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 15
Special Issue Editor
Interests: nervous system diseases; neuropharmacology; anatomy; biomolecular; musculoskeletal disorders; neuropathic pain
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuropeptides play key roles in neural development, synaptic transmission, neuroimmune interactions, and the regulation of inflammation, myelination, and regeneration. Understanding their signaling pathways and receptor dynamics at the molecular level is crucial to uncovering their impact on brain function and dysfunction. This Special Issue will encompass topics that explore the molecular functions and mechanisms of neuropeptides in the central nervous system (CNS), both under physiological and pathological conditions.
We welcome original research articles, reviews, systematic reviews, and meta-analyses that address neuropeptide-related mechanisms in healthy states as well as in neurodegenerative diseases, demyelinating disorders, neuropsychiatric conditions, or brain injury. Special emphasis will be placed on studies investigating intracellular signalling, gene and protein expression changes, receptor-ligand interactions, and cross-talk between neurons and glial cells.
Submissions highlighting translational aspects, such as neuropeptides as biomarkers or therapeutic targets, are encouraged, provided the work is supported by clear molecular or mechanistic data. Clinical studies and surveys without molecular analysis do not meet the journal’s scope.
This Special Issue aims to foster a deeper understanding of neuropeptide biology and promote research that bridges basic molecular insights with therapeutic development for CNS disorders.
Dr. Alessandro Castorina
Guest Editor
Manuscript Submission Information
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Keywords
- neuropeptides
- brain function
- neuroinflammation
- regeneration
- neurodegeneration
- biomarkers
- therapy
- CNS
- brain disorders
- demyelination
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