Announcements

Editor’s Choice Articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal. You are welcome to read the updated 2025 Q4 articles, a curated list of high-quality articles from Genes (ISSN 2073-4425).

A list of these papers is provided below:

1. “Crossroads of Iron Metabolism and Inflammation in Colorectal Carcinogenesis: Molecular Mechanisms and Therapeutic Perspectives”
by Nahid Ahmadi, Gihani Vidanapathirana and Vinod Gopalan
Genes 2025, 16(10), 1166; https://doi.org/10.3390/genes16101166
Full text available online: https://www.mdpi.com/2073-4425/16/10/1166

2. “RNA-Targeting Techniques: A Comparative Analysis of Modern Approaches for RNA Manipulation in Cancer Research and Therapeutics”
by Michaela A. Boti, Marios A. Diamantopoulos and Andreas Scorilas
Genes 2025, 16(10), 1168; https://doi.org/10.3390/genes16101168
Full text available online: https://www.mdpi.com/2073-4425/16/10/1168

3. “Physical Activity During Pregnancy and Gestational Weight Gain: Implications for Maternal–Fetal Epigenetic Programming and Long-Term Health”
by Nektaria Zagorianakou, Stylianos Makrydimas, Efthalia Moustakli, Ioannis Mitrogiannis, Ermanno Vitale and George Makrydimas
Genes 2025, 16(10), 1173; https://doi.org/10.3390/genes16101173
Full text available online: https://www.mdpi.com/2073-4425/16/10/1173

4. “Bridging Genotype to Phenotype in KMT5B-Related Syndrome: Evidence from RNA-Seq, 18FDG-PET, Clinical Deep Phenotyping in Two New Cases, and a Literature Review”
by Davide Politano, Renato Borgatti, Giulia Borgonovi, Angelina Cistaro, Cesare Danesino, Piercarlo Fania, Gaia Garghetti, Andrea Guala, Isabella Orlando, Irene Giovanna Schiera et al.
Genes 2025, 16(10), 1174; https://doi.org/10.3390/genes16101174
Full text available online: https://www.mdpi.com/2073-4425/16/10/1174

5. “A Genome-Wide Association Study in Psoriasis Patients Reveals Variants Associated with Response to Treatment with Interleukin-17A Pathway Inhibitors”
by Dimitra Ioakeimidou, Efterpi Zafiriou, Themistoklis Giannoulis, Olga Kouvarou, Kalliopi Gerogianni, Dimitrios P. Bogdanos, Theologia Sarafidou and Kalliopi Liadaki
Genes 2025, 16(10), 1187; https://doi.org/10.3390/genes16101187
Full text available online: https://www.mdpi.com/2073-4425/16/10/1187

6. “Fluid Biomarkers in Hereditary Spastic Paraplegia: A Narrative Review and Integrative Framework for Complex Neurodegenerative Mechanisms”
by Lorenzo Cipriano, Nunzio Setola, Melissa Barghigiani and Filippo Maria Santorelli
Genes 2025, 16(10), 1189; https://doi.org/10.3390/genes16101189
Full text available online: https://www.mdpi.com/2073-4425/16/10/1189

7. “How Close Are We to Achieving Durable and Efficacious Gene Therapy for Hemophilia A and B?”
by Patrycja Sosnowska-Sienkiewicz and Danuta Januszkiewicz-Lewandowska
Genes 2025, 16(10), 1200; https://doi.org/10.3390/genes16101200
Full text available online: https://www.mdpi.com/2073-4425/16/10/1200

8. “Epigenetic Modulation and Neuroprotective Effects of Neurofabine-C in a Transgenic Model of Alzheimer’s Disease”
by Ivan Carrera, Vinogran Naidoo, Lola Corzo, Olaia Martínez-Iglesias and Ramón Cacabelos
Genes 2025, 16(10), 1214; https://doi.org/10.3390/genes16101214
Full text available online: https://www.mdpi.com/2073-4425/16/10/1214

9. “Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1”
by Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki and Kiyoshi Ohtani
Genes 2025, 16(10), 1221; https://doi.org/10.3390/genes16101221
Full text available online: https://www.mdpi.com/2073-4425/16/10/1221

10. “Genetic Therapy of Fuchs Endothelial Corneal Dystrophy: Where Are We? A Review”
by Spela Stunf Pukl
Genes 2025, 16(10), 1222; https://doi.org/10.3390/genes16101222
Full text available online: https://www.mdpi.com/2073-4425/16/10/1222

11. “Stability Matters: Revealing Causal Roles of G-Quadruplexes (G4s) in Regulation of Chromatin and Transcription”
by Ke Xiao, Rongxin Zhang, Tiantong Tao, Huiling Shu, Hao Huang, Xiao Sun and Jing Tu
Genes 2025, 16(10), 1231; https://doi.org/10.3390/genes16101231
Full text available online: https://www.mdpi.com/2073-4425/16/10/1231

12. “Imprinting Disorders and Epigenetic Alterations in Children Conceived by Assisted Reproductive Technologies: Mechanisms, Clinical Outcomes, and Prenatal Diagnosis”
by Antonella Gambadauro, Valeria Chirico, Francesca Galletta, Ferdinando Gulino, Roberto Chimenz, Giorgia Serraino, Immacolata Rulli, Alessandro Manganaro, Eloisa Gitto and Lucia Marseglia
Genes 2025, 16(10), 1242; https://doi.org/10.3390/genes16101242
Full text available online: https://www.mdpi.com/2073-4425/16/10/1242

13. “Comparative Analysis of Chloroplast Genome Sequences and Phylogeny in Three Macadamia integrifolia Cultivars”
by Jihua Guo, Zhuanmiao Kang, Zhongchun Xiao, Chunyan Zhong, Guidong Miao, Pei Zhang, Weiwei Zhao, Rongrong Su and Kecan Xia
Genes 2025, 16(11), 1248; https://doi.org/10.3390/genes16111248
Full text available online: https://www.mdpi.com/2073-4425/16/11/1248

14. “Secondary Mitochondrial Dysfunction in Gaucher Disease Type I, II and III—Review of the Experimental and Clinical Evidence”
by Mollie Dewsbury, Tyler Purcell, Derralynn Hughes, Aimee Donald, Iain P. Hargreaves and Karolina M. Stepien
Genes 2025, 16(11), 1269; https://doi.org/10.3390/genes16111269
Full text available online: https://www.mdpi.com/2073-4425/16/11/1269

15. “Cardiac Genetic Variants in Sudden, Unexpected Death in Epilepsy: From Challenging DNA Extraction Methods to Updated NGS Panels for Improved Genetic Analysis”
by Alessia Bernini Di Michele, Valerio Onofri, Filomena Melchionda, Lucia Fiordelmondo, Eleonora Ciarimboli, Marco Palpacelli, Sara Sablone, Chiara Turchi and Mauro Pesaresi
Genes 2025, 16(11), 1272; https://doi.org/10.3390/genes16111272
Full text available online: https://www.mdpi.com/2073-4425/16/11/1272

16. “RNAi-Based Bioinsecticides for Controlling Vector-Borne Diseases”
by Krystal Maya-Maldonado, Antonio Celestino-Montes and Victor Cardoso-Jaime
Genes 2025, 16(11), 1276; https://doi.org/10.3390/genes16111276
Full text available online: https://www.mdpi.com/2073-4425/16/11/1276

17. “PMP22-Related Neuropathies: A Systematic Review”
by Carlo Alberto Cesaroni, Laura Caiazza, Giulia Pisanò, Martina Gnazzo, Giulia Sigona, Susanna Rizzi, Agnese Pantani, Daniele Frattini and Carlo Fusco
Genes 2025, 16(11), 1279; https://doi.org/10.3390/genes16111279
Full text available online: https://www.mdpi.com/2073-4425/16/11/1279

18. “Chloroplast Genome Features and Phylogeny of Two Nationally Protected Medicinal Plants, Euchresta tubulosa and Euchresta japonica: Molecular Resources for Identification and Conservation”
by Dabao Yin, Xue Li, Zhongchun Xiao and Li Zhou
Genes 2025, 16(11), 1286; https://doi.org/10.3390/genes16111286
Full text available online: https://www.mdpi.com/2073-4425/16/11/1286

19. “Toward a Multi-Trait Genetic Panel Targeting Training, Rehabilitation, and Chronic Disease Prevention: A Narrative Review”
by Antonio Imperatore, Cristina Mennitti, Giulia De Fonzo, Raffaele Amitrano, Alessandro Gentile, Mariella Calvanese, Fernanda Iafusco, Serena Coppola, Mattia Digno, Paola Borrelli et al.
Genes 2025, 16(11), 1309; https://doi.org/10.3390/genes16111309
Full text available online: https://www.mdpi.com/2073-4425/16/11/1309

20. “Complete Chloroplast Genome and Phylogenomic Analysis of Davallia trichomanoides (Polypodiaceae)”
by Yingying Wang, Ziqi Xiang, Keqin Liu, Yuan Lin and Siyuan Dong
Genes 2025, 16(11), 1310; https://doi.org/10.3390/genes16111310
Full text available online: https://www.mdpi.com/2073-4425/16/11/1310

21. “The miR-200 Family in Non-Small-Cell Lung Cancer: Molecular Mechanisms, Clinical Applications, and Therapeutic Implications”
by Nobuaki Kobayashi, Yukihito Kajita, Fangfei Yang, Nobuhiko Fukuda, Kohei Somekawa, Ayami Kaneko and Seigo Katakura
Genes 2025, 16(11), 1312; https://doi.org/10.3390/genes16111312
Full text available online: https://www.mdpi.com/2073-4425/16/11/1312

22. “Endometrial Signatures of Subfertility in Beef Heifers Reveal Dysregulation of MAPK Signaling and Ciliary Function”
by Nicholas C. Kertz, Priyanka Banerjee, Paul W. Dyce, Soren P. Rodning and Wellison J. Diniz
Genes 2025, 16(11), 1323; https://doi.org/10.3390/genes16111323
Full text available online: https://www.mdpi.com/2073-4425/16/11/1323

23. “Oxford Nanopore Technologies [ONT] Sequencing: Clinical Validation in Genetically Heterogeneous Disorders”
by Mario Urtis, Chiara Paganini, Viviana Vilardo, Antonio Tescari, Samantha Minetto, Claudia Cavaliere, Andrea Pilotto, Carmela Giorgianni, Alessia Cattaneo, Marilena Tagliani et al.
Genes 2025, 16(11), 1325; https://doi.org/10.3390/genes16111325
Full text available online: https://www.mdpi.com/2073-4425/16/11/1325

24. “Non-Coding RNAs as Emerging Regulators in Kidney Pathophysiology: From Molecular Mechanisms to Therapeutic Potential”
by Petar Todorović, Nikola Pavlović, Mirko Maglica, Patricija Bajt, Nela Kelam, Fila Raguž and Katarina Vukojević
Genes 2025, 16(11), 1328; https://doi.org/10.3390/genes16111328
Full text available online: https://www.mdpi.com/2073-4425/16/11/1328

25. “Genetic Analysis of Patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH): A Single-Center Observational Study”
by Zsuzsanna Bereczky, Gábor Kolodzey, Sarolta Borsos, László Balogh, Petra Erzsébet Biró, Éva Molnár, Katalin Rázsó, Andrea Péter, Judit Barta and Tibor Szűk
Genes 2025, 16(11), 1336; https://doi.org/10.3390/genes16111336
Full text available online: https://www.mdpi.com/2073-4425/16/11/1336

26. “GLP-1 Receptor Agonists in Solid Tumour Therapy: Exploring Their Anticancer Potential and Underlying Molecular Pathways”
by Daniela Lucente, Stefania Bellino and Anna La Salvia
Genes 2025, 16(11), 1352; https://doi.org/10.3390/genes16111352
Full text available online: https://www.mdpi.com/2073-4425/16/11/1352

27. “Breeding Selection for U.S. Siberian Huskies Has Altered Genes Regulating Metabolism, Endurance, Development, Body Conformation, Immune Function, and Behavior”
by Heather J. Huson, Krishnamoorthy Srikanth and Karolynn M. Ellis
Genes 2025, 16(11), 1355; https://doi.org/10.3390/genes16111355
Full text available online: https://www.mdpi.com/2073-4425/16/11/1355

28. “Genetic Predisposition and Genetic Resilience Factors in Stress-Related Disorders During the Developmental Age: A Narrative Review”
by Alessia Raffagnato, Arianna Raicich, Lisa Paiusco, Giulia Coser, Ilaria Bonemazzi, Andrea Gazzin, Maria Federica Pelizza, Caterina Ancora and Irene Toldo
Genes 2025, 16(11), 1362; https://doi.org/10.3390/genes16111362
Full text available online: https://www.mdpi.com/2073-4425/16/11/1362

29. “Curing Sickle Cell Disease by Allogeneic Hematopoietic Stem Cell (HSC) Transplantation Toward In Vivo HSC Gene Therapy”
by Rina Kansal
Genes 2025, 16(11), 1367; https://doi.org/10.3390/genes16111367
Full text available online: https://www.mdpi.com/2073-4425/16/11/1367

30. “Nutrigenomics and Epigenetics in the Dietary Management of Inflammatory Bowel Diseases”
by Patrycja Musz, Gabriela Ryś, Weronika Fic, Aneta Sokal-Dembowska and Sara Jarmakiewicz-Czaja
Genes 2025, 16(11), 1368; https://doi.org/10.3390/genes16111368
Full text available online: https://www.mdpi.com/2073-4425/16/11/1368

31. “Analysis of Human Degraded DNA in Forensic Genetics”
by Irena Zupanič Pajnič
Genes 2025, 16(11), 1375; https://doi.org/10.3390/genes16111375
Full text available online: https://www.mdpi.com/2073-4425/16/11/1375

32. “Genetic Assessment and Clinical Correlates in Severe Hypertriglyceridemia: A Systematic Review”
by Carmine De Luca, Paola Ciciola, Guido D’Errico, Maria Donata Di Taranto, Giuliana Fortunato, Carina Gross, Jonathan Garn, Gabriella Iannuzzo, Matteo Di Minno and Ilenia Calcaterra
Genes 2025, 16(11), 1377; https://doi.org/10.3390/genes16111377
Full text available online: https://www.mdpi.com/2073-4425/16/11/1377

33. “Molecular Characterization and Functional Effect on Canine Peripheral Blood Mononuclear Cells of an Uncharacterized Major Egg Antigen EGR-01664 from Echinococcus granulosus”
by Juncheng Huang, Xinwen Bo, Xuke Chen, Jiaxin Zhao, Jianan Zhao, Linying Wei, Yanyan Zhang, Yan Sun and Zhengrong Wang
Genes 2025, 16(11), 1384; https://doi.org/10.3390/genes16111384
Full text available online: https://www.mdpi.com/2073-4425/16/11/1384

34. “Sperm-Derived Extracellular Vesicles (Sperm-EVs), Emerging Biomarkers and Functional Modulators in Male Infertility and Assisted Reproduction”
by Charalampos Voros, Fotios Chatzinikolaou, Georgios Papadimas, Spyridon Polykalas, Despoina Mavrogianni, Aristotelis-Marios Koulakmanidis, Diamantis Athanasiou, Vasiliki Kanaka, Maria Kanaka, Kyriakos Bananis et al.
Genes 2025, 16(12), 1400; https://doi.org/10.3390/genes16121400
Full text available online: https://www.mdpi.com/2073-4425/16/12/1400

35. “Barriers, Limitations, and Experiences with Clinical Trials—Treatment in Rare Diseases with Prader–Willi Syndrome as an Example”
by Merlin G. Butler, Spencer Silvey and Harold J. P. van Bosse
Genes 2025, 16(12), 1436; https://doi.org/10.3390/genes16121436
Full text available online: https://www.mdpi.com/2073-4425/16/12/1436

36. “From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications”
by Sara Cannito, Ida Giardino, Maria D’Apolito, Alessandra Ranaldi, Francesca Scaltrito, Massimo Pettoello-Mantovani and Annamaria Piscazzi
Genes 2025, 16(12), 1442; https://doi.org/10.3390/genes16121442
Full text available online: https://www.mdpi.com/2073-4425/16/12/1442

37. “Role of Genetic and Epigenetic Biomarkers in Treatment-Resistant Depression: A Literature Review”
by Petra Sulić, Andrea Ražić Pavičić, Biljana Đapić Ivančić, Tamara Božina, Nada Božina and Maja Živković
Genes 2025, 16(12), 1443; https://doi.org/10.3390/genes16121443
Full text available online: https://www.mdpi.com/2073-4425/16/12/1443

38. “The Utility of Genome-Wide Association Studies in Inherited Arrhythmias and Cardiomyopathies”
by Saif Dababneh, Arya Ardehali, Jasleen Badesha and Zachary Laksman
Genes 2025, 16(12), 1448; https://doi.org/10.3390/genes16121448
Full text available online: https://www.mdpi.com/2073-4425/16/12/1448

39. “Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome”
by Alejandro Borrego-Ruiz and Juan J. Borrego
Genes 2025, 16(12), 1447; https://doi.org/10.3390/genes16121447
Full text available online: https://www.mdpi.com/2073-4425/16/12/1447

40. “From Skin to Brain: Key Genetic Mediators Associating Cutaneous Inflammation and Neurodegenerative Diseases”
by Vasiliki-Sofia Grech, Kleomenis Lotsaris, Vassiliki Kefala and Efstathios Rallis
Genes 2025, 16(12), 1463; https://doi.org/10.3390/genes16121463
Full text available online: https://www.mdpi.com/2073-4425/16/12/1463

41. “Artificial Intelligence-Driven Design of Antisense Oligonucleotides for Precision Medicine in Neuromuscular Disorders”
by Jamie Leckie, Sunny Wu, Terryanne Standell and Toshifumi Yokota
Genes 2025, 16(12), 1468; https://doi.org/10.3390/genes16121468
Full text available online: https://www.mdpi.com/2073-4425/16/12/1468

42. “RET Gene Alterations in Clinical Practice: A Comprehensive Review and Database Update”
by Claudio Ricciardi Tenore, Eugenia Tulli, Alessia Perrucci, Roberto Bertozzi, Ludovica Fortuna, Giulia Maneri, Concetta Santonocito, Andrea Urbani, Maria De Bonis and Angelo Minucci
Genes 2025, 16(12), 1472; https://doi.org/10.3390/genes16121472
Full text available online: https://www.mdpi.com/2073-4425/16/12/1472

43. “Preliminary Assessment of Arnica montana L. Extract: Antimicrobial Activity Against Acinetobacter baumannii and Biofilm-Related Gene Expression Profiling”
by Sylwia Andrzejczuk, Magdalena Sozoniuk and Danuta Sugier
Genes 2025, 16(12), 1473; https://doi.org/10.3390/genes16121473
Full text available online: https://www.mdpi.com/2073-4425/16/12/1473

44. “Underlying Mechanisms of GBA1 in Parkinson’s Disease and Dementia with Lewy Bodies: Narrative Review”
by Anastasia Bougea
Genes 2025, 16(12), 1496; https://doi.org/10.3390/genes16121496
Full text available online: https://www.mdpi.com/2073-4425/16/12/1496

45. “SIRT3-Mediated Mitochondrial Regulation and Driver Tissues in Systemic Aging”
by Kate Šešelja, Ena Šimunić, Sandra Sobočanec, Iva I. Podgorski, Marija Pinterić, Marijana Popović Hadžija, Tihomir Balog and Robert Belužić
Genes 2025, 16(12), 1497; https://doi.org/10.3390/genes16121497
Full text available online: https://www.mdpi.com/2073-4425/16/12/1497

46. “Exercise, APOE Genotype, and Testosterone Modulate Gut Microbiome–Cognition Associations in Prostate Cancer Survivors”
by Jacob Raber, Abigail O’Niel, Kristin D. Kasschau, Alexandra Pederson, Naomi Robinson, Carolyn Guidarelli, Christopher Chalmers, Kerri Winters-Stone and Thomas J. Sharpton
Genes 2025, 16(12), 1507; https://doi.org/10.3390/genes16121507
Full text available online: https://www.mdpi.com/2073-4425/16/12/1507

47. “Brain Matters in Duchenne Muscular Dystrophy: DMD Mutation Sites and Their Association with Neurological Comorbidities Through Isoform Impairment”
by Teodora Barbarii, Raluca Anca Tudorache, Dana Craiu, Elena Neagu, Lacramioara Aurelia Brinduse, Carmen Magdalena Burloiu, Catrinel Mihaela Iliescu, Magdalena Budisteanu, Ioana Minciu, Diana Gabriela Barca et al.
Genes 2026, 17(1), 12; https://doi.org/10.3390/genes17010012
Full text available online: https://www.mdpi.com/2073-4425/17/1/12

48. “Complete Chloroplast Genome Sequence and Phylogenetic Analysis of the Tibetan Medicinal Plant Soroseris hookeriana”
by Tian Tian, Xiuying Lin, Yiming Wang and Jiuli Wang
Genes 2026, 17(1), 24; https://doi.org/10.3390/genes17010024
Full text available online: https://www.mdpi.com/2073-4425/17/1/24

49. “Review of Genomic Drivers of Thyroid Cancer and Their Clinical Implications”
by Sobrina Mohammed, Daniel Mettman, Axel Hugo Breier, Vaishali Patel and Mariana Garcia-Touza
Genes 2026, 17(1), 36; https://doi.org/10.3390/genes17010036
Full text available online: https://www.mdpi.com/2073-4425/17/1/36