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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics and Breeding Improvements in Sheep and Goat

edited by

Kaiping Deng

submission deadline 15 May 2026 | 2 articles | Viewed by 2905 | Submission Open

Keywords: genetics; breeding improvement; genomic selection; molecular markers

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Cattle Genetics, Genomics and Breeding: From Molecular Insights to Sustainable Production

edited by

Hinayah Rojas De Oliveira

submission deadline 15 May 2026 | 2 articles | Viewed by 2352 | Submission Open

Keywords: bovine; Bos taurus taurus; Bos taurus indicus; genomic selection; GWAS; multi-omics; gene editing; breeding strategies; reproductive technologies; genetic diversity; adaptation genetics; disease resistance; epigenetics; climate resilience; sustainable production; precision livestock farming

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics and Treatment of Inherited Neurological Diseases of the Spinal Cord

edited by

Christopher Grunseich

submission deadline 15 May 2026 | 1 articles | Viewed by 1451 | Submission Open

Keywords: motor neuron disease; hereditary spastic paraplegias; spastic ataxia; inborn errors in metabolism; adrenomyeloneuropathy; leukodystrophy

(This special issue belongs to the Section Neurogenomics)

Genetic Regulation of Plant Metabolism in Environmental Adaptation

edited by

Zenglin Zhang

Zhiyong Ni

and Danmei Liu

submission deadline 15 May 2026 | 2 articles | Viewed by 1305 | Submission Open

Keywords: plant metabolism; environmental adaptation; genetic regulation; stress response; metabolic engineering; multi-omics integration; gene regulatory networks

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Insights into Pediatric Neurological Disorders: From Mechanisms to Therapies

edited by Ji Yoon Han

submission deadline 15 May 2026 | 1 articles | Viewed by 814 | Submission Open

Keywords: pediatric neurological disorders; neurogenetics; multi-omics integration; precision medicine; brain organoid models

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Basis and Therapeutics of Neurodegenerative Diseases

edited by

Tânia Soares Martins

submission deadline 15 May 2026 | Viewed by 512 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis (ALS); molecular mechanisms; protein misfolding and aggregation; mitochondrial dysfunction; neuroinflammation; extracellular vesicles (EVs); gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Studies of Cancer Therapy

edited by Nikos G. Gavalas

submission deadline 15 May 2026 | Viewed by 246 | Submission Open

Keywords: genetics; cancer; oncology; genetic variations; response; treatment; epigenetics; genomics; biomarkers; modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Development of Genetic Assessment for Neurotoxicity

edited by

and

submission deadline 20 May 2026 | 3 articles | Viewed by 3697 | Submission Open

Keywords: neurotoxicity; genetics; neurodegenerative disorders; mental disorders

(This special issue belongs to the Section Toxicogenomics)

Novel Strategies in Forensic Genetics

edited by

Marie Allen

submission deadline 20 May 2026 | 2 articles | Viewed by 1810 | Submission Open

Keywords: foresic DNA analysis; sample collection; DNA extraction; novel DNA markers; MPS; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genomic, Transcriptome Analysis in Animals

edited by

Min Yang

and Mengxun Li

submission deadline 20 May 2026 | 2 articles | Viewed by 1553 | Submission Open

Keywords: multi-omics methodologies; genetic and epigenetic regulation; mechanisms of the elucidation of domesticated animal physiological characteristics and economic traits

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular Basis and Genetics of Neurodevelopmental Disorders

edited by

Pietro Palumbo

Massimo Carella

and

Orazio Palumbo

submission deadline 20 May 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: neurodevelopmental disorders; next-generation sequencing; chromosomal microarray analysis; disease models; translational impact

(This special issue belongs to the Section Neurogenomics)

Utilizing Gene Editing to Improve Plant Breeding

edited by

Li Sun

submission deadline 20 May 2026 | Viewed by 359 | Submission Open

Keywords: gene editing; crop breeding; CRISPR-Cas9; VIGE (virus induced gene editing); sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Statistical Genetics and Its Applications

edited by

Zhongxue Chen

submission deadline 20 May 2026 | Viewed by 275 | Submission Open

Keywords: statistics genetics; causal inference; meta-analysis; Mendelian randomization; machine learning; genotype; phenotype; GWAS

(This special issue belongs to the Section Bioinformatics)

Genetic and Functional Genomics Insights into the Genetic Improvement of Stress Resistance in Economic Crops

edited by

Mingku Zhu

and Xiaoqing Meng

submission deadline 25 May 2026 | 5 articles | Viewed by 6678 | Submission Open

Keywords: economic crops; functional genomics; molecular biology; genetic improvement; agricultural biotechnology

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Diagnosis and Treatment of Duchenne Muscular Dystrophy

edited by Liubov V. Gushchina

submission deadline 25 May 2026 | 4 articles | Viewed by 4879 | Submission Open

Keywords: Duchenne muscular dystrophy; viral vectors; non-viral therapy; gene editing; common and rare mutations; biomarkers; methods of diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Clinical Genetics of Diabetes

edited by

Tuncay Delibasi

submission deadline 25 May 2026 | 4 articles | Viewed by 3586 | Submission Open

Keywords: precision diabetology; genomics; β -cell dysfunction; insulin resistance; pharmacogenomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Breeding Improvement of Horticultural Crops

edited by

Zhiqiang Wu

and

Xiaoni Zhang

submission deadline 25 May 2026 | 5 articles | Viewed by 3520 | Submission Open

Keywords: chloroplast genome; mitochondrial genome; nuclear genome; gene family evolution; functional genomics; genome editing; molecular breeding; horticultural crops

(This special issue belongs to the Section Plant Genetics and Genomics)

Application of Molecular or Genetic Markers in Liquid Biopsy for Urogenital Cancers

edited by

Guorong Li

submission deadline 25 May 2026 | 1 articles | Viewed by 2390 | Submission Open

Keywords: liquid biopsy; extracellular vesicle; exosome; biotechnology; precision medicine/personalized medicine; diagnosis/screening; urogenital cancer

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pediatric Neurology and Genetics

edited by

Roberta Milone

, Agatino Battaglia and Alberto Danieli

submission deadline 25 May 2026 | 1 articles | Viewed by 1477 | Submission Open

Keywords: rare neurological diseases; genomics; next-generation sequencing; cytogenetics; child neurology

(This special issue belongs to the Section Neurogenomics)

Plant Responses to Abiotic Stress: Genetics, Transcription, Noncoding RNAs, and Epigenetics

edited by

Runlai Hang

submission deadline 25 May 2026 | 2 articles | Viewed by 1319 | Submission Open

Keywords: abiotic stress responses; LncRNA; RNA biology; translation; miRNA; siRNA; rRNA; epigenetics; DNA methylation; RNA modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Innovations in Aquaculture Breeding via Genetic Technologies

edited by

Lei Liu

submission deadline 25 May 2026 | 1 articles | Viewed by 1000 | Submission Open

Keywords: aquaculture species; molecular breeding; genomic; behavioral traits; reproduction and development; genome editing; whole-genome sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic and Genomic Innovations for Developing Resilient Crops

edited by

Huajin Sheng

and

Sheng Wang

submission deadline 25 May 2026 | Viewed by 440 | Submission Open

Keywords: crop improvement; abiotic stress; gene function; transcriptomics; gene editing; molecular breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Integrative Cancer Genomics: Unveiling Novel Biomarkers

edited by

Victor Jin

and

Shengtong Han

submission deadline 25 May 2026 | Viewed by 398 | Submission Open

Keywords: cancer; integrative genomics; cancer biomarker; multi-omics; cancer genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Systems Genomics, Mitochondrial Dysfunction, and Immune Dysregulation in Ehlers–Danlos Syndromes and Heritable Connective Tissue Disorders

edited by Arash Shirvani

submission deadline 25 May 2026 | Viewed by 376 | Submission Open

Keywords: Ehlers– Danlos syndrome; hypermobile Ehlers– Danlos syndrome; heritable connective tissue disorders; human genomics; mitochondrial dysfunction; mast cell activation; variant interpretation; genotype– phenotype correlation; multi-omics; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mutations and Molecular Mechanisms in Human Diseases

edited by Ying Chen Claire Hou and Mariam Mathew

submission deadline 25 May 2026 | Viewed by 355 | Submission Open

Keywords: genetics; cytogenetics; genome sequencing; RNA sequencing; functional genomics; precision medicine; epigenetics; DNA methylation; single-cell technologies; spatial omic technologies; human diseases

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Molecular Mechanisms of Insect Resistance

edited by Fen Li and Shuqian Tan

submission deadline 25 May 2026 | Viewed by 340 | Submission Open

Keywords: insect resistance; molecular mechanisms; genetic basis; detoxification enzymes; cytochrome P450; target-site resistance; metabolic resistance; gene amplification; gene expression regulation; genomics; transcriptomics; gene editing; adaptive evolution; insecticide resistance management (IRM); pest management

(This special issue belongs to the Section Animal Genetics and Genomics)

Advancing Precision Medicine for Lung Cancer Through Genomics

edited by Elisa De Paolis

submission deadline 25 May 2026 | Viewed by 310 | Submission Open

Keywords: lung cancer; liquid biopsy; tissue biopsy; next-generation sequencing; genomics; clinical medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics of Head and Neck Disorders

edited by Christos Yapijakis

submission deadline 25 May 2026 | Viewed by 213 | Submission Open

Keywords: head and neck pathology; craniofacial genetics; orofacial genetics; developmental genetics; neurogenetics; cancer genetics; genomics and gene variation; epigenetics; personalized medicine and dentistry; genetic counseling and ethics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic, Epigenetic and Environmental Factors in Dental Development and Pathologies: Genes, Interactions and Dental Development

edited by

Alan H. Brook

submission deadline 5 Jun 2026 | 21 articles | Viewed by 72947 | Submission Open

Keywords: dental development; genetics; epigenetics; complex adaptive systems; interactive networks

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genes and Pediatrics

edited by

Giorgia Ceravolo

and

Roberto Chimenz

submission deadline 5 Jun 2026 | 5 articles | Viewed by 8580 | Submission Open

Keywords: pediatric disease; genetic variant; clinical observation; diagnosis; patient care

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

The Genetics of Male Infertility and Clinical Implications

edited by

Gianmaria Salvio

submission deadline 5 Jun 2026 | 3 articles | Viewed by 4088 | Submission Open

Keywords: genetics; male infertility; azoospermia; next generation sequencing; genetic variants

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Biomarkers in Cancer: From Discovery to Clinical Application

edited by

Evangelos Koustas

submission deadline 5 Jun 2026 | 1 articles | Viewed by 2031 | Submission Open

Keywords: cancer; tumor biology; biomarkers; cancer therapy; targeted therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Mechanisms of Plant Resistance to Biotic Stress

edited by

Zhuo Chen

submission deadline 5 Jun 2026 | 2 articles | Viewed by 1185 | Submission Open

Keywords: plant diseases; biotic stress; resistance genes; genetics; genomics; plant hosts

(This special issue belongs to the Section Plant Genetics and Genomics)

Single-Cell and Spatial Multi-Omics in Human Diseases

edited by

Xin Wang

submission deadline 10 Jun 2026 | 4 articles | Viewed by 9864 | Submission Open

Keywords: single-cell omics; spatial multi-omics; pathogenesis of disease; biomarkers; computational tools; integrative biology

(This special issue belongs to the Section Bioinformatics)

Genetic and Molecular Insights into Cardiovascular Disease: From Mechanisms to Precision Medicine

edited by

Lingfeng Luo

and

Laurent Metzinger

submission deadline 10 Jun 2026 | 7 articles | Viewed by 5077 | Submission Open

Keywords: cardiovascular disease; genetic variants; precision medicine; epigenetics; non-coding RNAs; polygenic risk scores; mendelian randomization; biomarkers; genome-wide association studies (GWASs); molecular mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Epidemiology of Parasites

edited by

Joanna Da̧browska

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1696 | Submission Open

Keywords: parasite genetics; parasite genomics; WGS; molecular epidemiology; zoonoses; virulence and pathogenesis; transmission dynamics; genetic diversity

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetic Basis of Pig Breeding and Regulation of Meat Production Efficiency and Quality Control

edited by

Mailin Gan

and Liyuan Shen

submission deadline 10 Jun 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: pig; meat; molecular mechanism; multi-omics; production efficiency

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetics of Substance Use and Addictions

edited by

Eric R. Braverman

submission deadline 10 Jun 2026 | Viewed by 275 | Submission Open

Keywords: genetics of addiction; substance use disorders; dopamine; catecholamines; polygenic risk; epigenetics; neuroendocrine regulation; deep phenotyping; reward deficiency syndrome; GARS; gene– phenotype classification

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances and Challenges in Forensic Genetics

edited by

Maria Helena Correia Dias

and

Venusia Cortellini

submission deadline 15 Jun 2026 | 8 articles | Viewed by 12674 | Submission Open

Keywords: DNA analysis; DNA methylation applications; biogeographic ancestry; age estimation approaches; discrimination of monozygotic twins; discrimination of tissues; next-generation sequencing; forensic cases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Updates in Forensic Genetics

edited by Massimo Lancia

submission deadline 15 Jun 2026 | 3 articles | Viewed by 4932 | Submission Open

Keywords: next generation sequencing; single cell analysis; time since deposition; time since death; DNA phenotyping; biogeographic ancestry; age prediction; familial search; disaster victim identification; trace DNA contextualisation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Plant Genetics, Evolution, Cytogenetics and Cytogenomics for Biodiversity Conservation

edited by

Eric Javier Martínez

Ana Isabel Honfi

and

Anna Reutemann

submission deadline 15 Jun 2026 | 3 articles | Viewed by 3960 | Submission Open

Keywords: plant conservation; cytogenetics; cytogenomics; plant evolution; population genetics; genome evolution; chromosomal variation; polyploidy; biodiversity; genomic resources

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics of Autism Spectrum Disorders

edited by

Roberto Canitano

and

Marco Carotenuto

submission deadline 15 Jun 2026 | 1 articles | Viewed by 2798 | Submission Open

Keywords: autism spectrum disorders; genetics; new techniques for diagnosis

(This special issue belongs to the Section Neurogenomics)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Jun 2026 | 1 articles | Viewed by 1534 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

Targeting RNA Coding Mechanisms in Disease Molecular Pathways

edited by

Wangyong Yang

submission deadline 15 Jun 2026 | Viewed by 337 | Submission Open

Keywords: RNA therapeutics; RNA modifications (epitranscriptomics); non-coding RNA (ncRNA); alternative splicing; RNA-binding proteins (RBPs); RNA-targeted small molecules; gene therapy; molecular pathways; disease biomarkers; RNA vaccines

(This special issue belongs to the Section RNA)

Mitochondrial Genetics in Health and Disease

edited by Jing Wang

submission deadline 15 Jun 2026 | Viewed by 288 | Submission Open

Keywords: primary mitochondrial disorders; mitochondrial DNA; mitochondrial dysfunction; diagnosis; therapeutic approaches

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Breeding of Forage—2nd Edition

edited by Maofeng Chai

submission deadline 15 Jun 2026 | Viewed by 262 | Submission Open

Keywords: forage genetic improvement; molecular breeding; abiotic stress; biotic stress; population genetics; multi-omics analysis; nutrition absorption

(This special issue belongs to the Section Plant Genetics and Genomics)

Research on Genetics and Breeding of Rice

edited by Xiaojin Luo

submission deadline 20 Jun 2026 | 4 articles | Viewed by 3150 | Submission Open

Keywords: rice breeding; molecular genetics; rice germplasm; QTL identification and gene cloning; genetic function and genetic network; breeding technologies

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms

edited by Xueyuan Li, Juyun Zheng,

Jie Sun

and Fenglei Sun

submission deadline 20 Jun 2026 | 2 articles | Viewed by 1848 | Submission Open

Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics in Cancer

edited by

Rina Kansal

submission deadline 20 Jun 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: solid tumors; breast cancer; colon cancer; lung cancer; prostate cancer; gastrointestinal; gynecologic cancer; genitourinary cancers; brain tumors; hematolymphoid neoplasms; myeloid neoplasms; lymphoid neoplasms; hereditary cancer; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancements in Pharmacogenomics for Precision Medicine

edited by

Óscar Teijido Hermida

submission deadline 20 Jun 2026 | Viewed by 347 | Submission Open

Keywords: pharmacogenomics; precision medicine; pharmacoepigenomics; epidrugs; genomic biomarkers; drug response variability; personalized therapy; multi-omics integration; pharmacogenetic testing; clinical implementation; artificial intelligence in pharmacogenomics; genetic polymorphisms; translational genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

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