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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Genetics of Malignant Hyperthermia Susceptibility and Related Diseases

edited by Nyamkhishig Sambuughin

submission deadline 5 Aug 2025 | 1 articles | Viewed by 672 | Submission Open

Keywords: malignant hyperthermia; malignant hyperthermia susceptibility; RYR1; CACNA1S; STAC3; RYR1 related congenital myopathies; exertional rhabdomyolysis; exertional heat illness

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Neurodevelopmental Disorders

edited by

Andrea Conidi

submission deadline 15 Aug 2025 | 1 articles | Viewed by 2980 | Submission Open

Keywords: neurodevelopmental disorders; rare diseases; chromatin architecture; iPSCs and organoids; transcription factors

(This special issue belongs to the Section Neurogenomics)

Neuropsychiatric Disorders: Genetics and Targeted Therapy

edited by Lace Riggs and Xin Fu

submission deadline 15 Aug 2025 | 1 articles | Viewed by 1961 | Submission Open

Keywords: neuropsychiatric disorders; polygenetic interactions; genotype– phenotype correlations; neural circuits; synaptic transmission; synaptic plasticity

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Genetics of Metabolism and Related Diseases

edited by

Marianna Aprile

, Simona Cataldi and

Gaetana Napolitano

submission deadline 15 Aug 2025 | Viewed by 262 | Submission Open

Keywords: genetic; epigenetic; metabolic pathways; adipose tissue biology; metabolic disorders; functional genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomic Basis of Pediatric Kidney Diseases

edited by

Enrico Cocchi

submission deadline 15 Aug 2025 | Viewed by 168 | Submission Open

Keywords: pediatric nephrology; genetic disease; clinical genetics; molecular pathology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genomics, Evolution, Epidemiology and Tools for Microbiome Research

edited by

Ayixon Sánchez-Reyes

submission deadline 20 Aug 2025 | Viewed by 728 | Submission Open

Keywords: microbiome genomics and evolution; metagenomics on epidemiology; phylogenetics; comparative genomics; pathogen genomics and antimicrobial resistance; bioinformatics tools and methods; pathogen surveillance including viruses; functional genomics; marker genes in systematics and taxonomy; inference of causal variants in environmental and antimicrobial resistance phenotypes

(This special issue belongs to the Section Microbial Genetics and Genomics)

The Function of Regulatory RNAs in Bacterial Pathogens

edited by

Runhua Han

submission deadline 20 Aug 2025 | Viewed by 115 | Submission Open

Keywords: regulatory small RNA; pathogenic bacteria; virulence; RNA regulation; host– pathogen interaction; stress response

(This special issue belongs to the Section Microbial Genetics and Genomics)

From Genetic to Molecular Basis of Kidney Diseases

edited by

Mariadelina Simeoni

submission deadline 25 Aug 2025 | 2 articles | Viewed by 3691 | Submission Open

Keywords: renal rare diseases; chronic kidney disease (CKD); acute kidney injury (AKI); glomerulonephritis; onconephrology; inherited glomerulopathies and tubulopathies; cardio-nephrology syndromes; neuro-nephrology syndromes; endocrine nephrology syndromes; Kidney transplantation ; Hemodialysis; Peritoneal dialysis

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics in Retinal Diseases—2nd Edition

edited by

Chloe M. Stanton

submission deadline 25 Aug 2025 | 3 articles | Viewed by 3660 | Submission Open

Keywords: retina; genetics; inherited retinal disease; genomics; genetic therapies; disease models; disease mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Clinical Molecular Genetics in Hematologic Diseases

edited by

Zhenya Tang

and Lei Zhang

submission deadline 25 Aug 2025 | 2 articles | Viewed by 3089 | Submission Open

Keywords: hematologic diseases; genetic aberration; hematologic malignancies; next generation sequencing (NGS); precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cytogenetics and Cytogenomics in Clinical Diagnostics: Innovations and Applications

edited by

Jinglan Liu

submission deadline 25 Aug 2025 | 3 articles | Viewed by 2596 | Submission Open

Keywords: karyotyping; cytogenomics; chromosome territory (CT); nuclear architecture; clinical oncology; germline; development; neuropsychiatry; artificial intelligence (AI)

(This special issue belongs to the Section Cytogenomics)

Genes and Gene Therapies in Chronic Renal Disease

edited by Thomas Kitzler

submission deadline 25 Aug 2025 | 2 articles | Viewed by 2342 | Submission Open

Keywords: chronic renal disease; personalized medicine; exome and genome sequencing; nephrogenetics; genetic kidney disease; small molecules; mRNA therapies; gene editing; gene delivery

(This special issue belongs to the Section Molecular Genetics and Genomics)

Phenotypic Variability of Genetic Diseases in Children

edited by Ben Pode-Shakked

submission deadline 25 Aug 2025 | 1 articles | Viewed by 1136 | Submission Open

Keywords: phenotypic variability; genetic disorders; rare diseases; neurodevelopmental disorders; craniofacial anomalies; next-generation sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Epigenetic Regulation in Tumors

edited by

Anca Botezatu

submission deadline 25 Aug 2025 | Viewed by 713 | Submission Open

Keywords: cancer epigenetics; epigenetic mechanisms; tumor microenvironment; epigenetic biomarkers; multi-omics and bioinformatics

(This special issue belongs to the Section Epigenomics)

Genetic Research on Crop Stress Resistance and Quality Traits

edited by

Zenglin Zhang

Zhiyong Ni

and

Lichao Zhang

submission deadline 25 Aug 2025 | 1 articles | Viewed by 583 | Submission Open

Keywords: genetic and epigenetic regulation; plant stresses response; multi-omics data analysis; regulation of plant senescence; plant regulatory hormones; mechanisms of the elucidation of plant molecular and physiological traits

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic and Epigenetic Insights of Birth Defects

edited by José Suazo

submission deadline 25 Aug 2025 | Viewed by 254 | Submission Open

Keywords: birth defects; epigenetics; genetic; human embryo development; molecular pathways; gene expression; epigenetic marks

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Fragile X Syndrome and Fragile X Premutation Associated Conditions

edited by

Dragana D. Protic

and

Maja Stojković

submission deadline 25 Aug 2025 | Viewed by 217 | Submission Open

Keywords: FMR1 gene; FMRP; fragile X syndrome; fragile X premutation-associated conditions (FXPAC); molecular mechanisms; targeted treatment and gene therapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Clinical Diagnosis and Analysis of Cancers

edited by Elisa De Paolis

submission deadline 25 Aug 2025 | Viewed by 160 | Submission Open

Keywords: cancer genetics; cancer proteomics; cancer diagnosis; cancer treatments; next-generation sequencing; genetic editing ; machine learning ; artificial intelligence

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetics and Genomics of Retinal Development and Diseases

edited by

Jiaxiong Lu

submission deadline 25 Aug 2025 | Viewed by 118 | Submission Open

Keywords: inherited retinal diseases; retina organoids; genetic networks; retina; CRISPR-based genome editing

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Mechanisms of Embryogenesis in Mammal

edited by Federico Zurita

submission deadline 25 Aug 2025 | Viewed by 112 | Submission Open

Keywords: gene regulation; blastocyst; chromatin; cell migration; gastrulation; mouse; MicroRNAs; apoptosis; neurulation; organogenesis

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Improvement in Rice: Enhancing Environmental Sustainability and Global Health

edited by Hao Chen

submission deadline 25 Aug 2025 | Viewed by 110 | Submission Open

Keywords: oryza sativa; genetic improvement; yield and related traits; resistance to biotic and abiotic stresses; nutrient-use efficiency; nutrional quality

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Pig Genetic and Genomic Breeding

edited by

Kang Xu

and

Kejun Wang

submission deadline 31 Aug 2025 | 8 articles | Viewed by 17694 | Submission Open

Keywords: pig genome; pig breeding; multi-omics; economic traits; molecular maker

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances and Challenges in Forensic Genetics

edited by

Maria Helena Correia Dias

and

Venusia Cortellini

submission deadline 31 Aug 2025 | Viewed by 194 | Submission Open

Keywords: DNA analysis; DNA methylation applications; biogeographic ancestry; age estimation approaches; discrimination of monozygotic twins; discrimination of tissues; next-generation sequencing; forensic cases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Breeding of Forage

edited by Maofeng Chai and Zhenyi Li

submission deadline 5 Sep 2025 | 2 articles | Viewed by 1217 | Submission Open

Keywords: forage genetic improvement; molecular breeding; abiotic stress; biotic stress; population genetics; multi-omics analysis; nutrition absorption

(This special issue belongs to the Section Plant Genetics and Genomics)

Roles of RNAs in Biology

edited by

Zihua Hu

submission deadline 5 Sep 2025 | Viewed by 123 | Submission Open

Keywords: regulatory RNAs; non-coding RNAs; RNA in disease and therapy; RNA modifications including editing; RNA-RNA interaction including microRNAs; RNA in transcriptional and post-transcriptional regulation; non-coding RNA in epigenetic regulation

(This special issue belongs to the Section RNA)

Molecular Genetics of Rare Disorders

edited by Miriam Lucia Carriero

submission deadline 10 Sep 2025 | 1 articles | Viewed by 983 | Submission Open

Keywords: rare diseases; molecular genetics; gene– disease associations; genotype– phenotype correlation; targeted gene therapy; next-generation sequencing; whole-genome sequencing; genome-wide association studies; functional genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advance in Non-invasive Prenatal Testing: Ten Years of cfDNA-Based Screening and Diagnosis

edited by

Luigia De Falco

and Erica Soster

submission deadline 15 Sep 2025 | 7 articles | Viewed by 15318 | Submission Open

Keywords: prenatal screening; circulating cell-free DNA (cfDNA); non-invasive prenatal testing (NIPT); genome-wide sequencing; monogenic diseases

(This special issue belongs to the Section Technologies and Resources for Genetics)

Animal Models, Genetic and Genomic Studies in Cancer and Its Therapy

edited by

Dongyu Jia

Yinu Wang

and

Yoichiro Tamori

submission deadline 15 Sep 2025 | 3 articles | Viewed by 7264 | Submission Open

Keywords: animal model; cancer model; application; translational research; cancer biology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Treatment in Neurodegenerative Diseases

edited by Valentino Rački and

Gaber Bergant

submission deadline 15 Sep 2025 | 2 articles | Viewed by 1079 | Submission Open

Keywords: neurodegeneration; genetics; Alzheimer’ s disease; Parkinson’ s disease; gene therapy; pharmacogenomics; precision medicine

(This special issue belongs to the Section Neurogenomics)

Genetics and Epigenetics in Neurological Disorders

edited by Julien Philippe

submission deadline 15 Sep 2025 | 1 articles | Viewed by 943 | Submission Open

Keywords: genetic; epigenetic; neurodegeneration; pathomechanisms; neurotherapeutics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Breeding and Genetics of Plant Drought Resistance

edited by

Ivan Pejić

and Miroslav Bukan

submission deadline 15 Sep 2025 | 1 articles | Viewed by 655 | Submission Open

Keywords: climate change; abiotic stress; drought assessment; plant phenotyping; drought resistance; molecular breeding; marker assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

Utilizing High-Throughput Sequencing and Deep Learning to Uncover Disease Epigenetic Mechanisms

edited by Fuying Dao and Hao Lv

submission deadline 15 Sep 2025 | 1 articles | Viewed by 501 | Submission Open

Keywords: epigenomics; deep Learning; three-dimensional chromatin interactions; high-throughput sequencing; disease biomarkers

(This special issue belongs to the Section Bioinformatics)

Pediatric Rare Diseases: Genetics and Diagnosis

edited by Antonio F. Martínez‐Monseny

submission deadline 15 Sep 2025 | 1 articles | Viewed by 428 | Submission Open

Keywords: rare diseases; genetics; pediatrics; dysmorphology; molecular diagnosis; genetic syndromes; genome; precision medicine; phenotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Basis and Therapeutics of Neurodegenerative Diseases

edited by

Tânia Soares Martins

submission deadline 15 Sep 2025 | Viewed by 127 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis (ALS); molecular mechanisms; protein misfolding and aggregation; mitochondrial dysfunction; neuroinflammation; extracellular vesicles (EVs); gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Psychiatric Pharmacogenomics

edited by Martina Hahn

submission deadline 15 Sep 2025 | Viewed by 67 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; pharmacokinetics; therapeutic drug monitoring; psychotropic drugs; psychiatric pharmacogenomics

(This special issue belongs to the Section Pharmacogenetics)

Molecular Basis and Genetics of Intellectual Disability

edited by

Orazio Palumbo

Massimo Carella

and

Pietro Palumbo

submission deadline 20 Sep 2025 | 6 articles | Viewed by 12115 | Submission Open

Keywords: ID-related genes; new syndromic and non-syndromic forms of ID; neurodevelopmental disorders; genotype– phenotype correlations; non-coding RNAs and ID; next-generation sequencing; chromosome microarray analysis; animal models; iPSCs

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders

edited by

Stefania Zampatti

and

Emiliano Giardina

submission deadline 20 Sep 2025 | 1 articles | Viewed by 793 | Submission Open

Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Batch Effects in High Dimensional Biological Data—Detection, Correction and Challenges

edited by

Miguel Andrade

and Maximilian Sprang

submission deadline 20 Sep 2025 | Viewed by 186 | Submission Open

Keywords: batch effects; artifacts; RNA seq; omics; quality control; single cell; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Molecular Evolution, Mitochondrial Genomics and Mitochondrial Genome Expression in Animals: 2024–2025

edited by

Jiayong Zhang

and

Jiasheng Hao

submission deadline 25 Sep 2025 | 13 articles | Viewed by 10600 | Submission Open

Keywords: mitochondrial genome; gene arrangement; phylogenetic relationship; mitochondrial gene expression; molecular evolution

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Machine Learning in Cancer and Disease Genomics

edited by

Piero Fariselli

and Giovanni Birolo

submission deadline 25 Sep 2025 | 4 articles | Viewed by 6214 | Submission Open

Keywords: machine learning; cancer genomics; disease genomics; bioinformatics; genomic data analysis; biomarker discovery; multi-omics integration; personalized medicine; computational biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advanced Research in Forensic Genetics

edited by

Mauro Pesaresi

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1526 | Submission Open

Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STRs); single-nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Influences on Depression: Emerging Therapies and Biomarkers

edited by Jelena Milić

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1334 | Submission Open

Keywords: depression; epigenetics; genetic predisposition; environmental factors; epigenetic biomarkers; mental health therapies; stress and depression; DNA methylation; histone modifications; transgenerational effects

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Craniofacial Genetics

edited by Christos Yapijakis

submission deadline 25 Sep 2025 | 1 articles | Viewed by 819 | Submission Open

Keywords: craniofacial syndromes; dysmorphology; genetics; epigenetics; gene– environment interactions; animal models; therapeutic protocols; cranial neural crest; cleft lip and palate; auditory– vestibular malformations

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 25 Sep 2025 | 1 articles | Viewed by 584 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

Inherited Retinal Diseases: Genetic Research and Novel Therapeutic Prospects

edited by

Ditta Zobor

submission deadline 25 Sep 2025 | 1 articles | Viewed by 490 | Submission Open

Keywords: inherited retinal degeneration; ophthalmogenetics; genotype– phenotype correlations; gene therapy; optogenetics; stem cell therapy; neuroprotection; clinical studies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Mitochondrial Genetics: Progress and Challenges

edited by

Konstantin Khrapko

submission deadline 25 Sep 2025 | Viewed by 172 | Submission Open

Keywords: Mitochondria; ; mtDNA; ; mutation; ; selection; ; germline; ; mitchondrial disease; ; inheritance; ; population; ; evolution; ; NUMT

(This special issue belongs to the Section Molecular Genetics and Genomics)

Integrative Epigenetic Regulation in Crop Stress Resistance: Multi-Omics-Guided Gene Mining and Molecular Breeding

edited by Qiutao Xu, Baoqi Li and

Xuan Ma

submission deadline 25 Sep 2025 | Viewed by 142 | Submission Open

Keywords: epigenetic regulation; DNA methylation; histone modifications; RNA biology; multi-omics; abiotic stress resilience; transgenerational epigenetic inheritance; transcriptional regulation; phenotypic plasticity

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Epigenetics in Plant Development

edited by Chao Bian

submission deadline 25 Sep 2025 | Viewed by 135 | Submission Open

Keywords: plant development; genetics; epigenetics; genome editing; epigenetics; gene regulation; DNA methylation; chromatin remodeling; transcriptional networks; environmental signaling

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Genetic Analysis of Congenital Disorders

edited by

Ewelina Bukowska-Olech

Pawel Gawlinski

and Katarzyna Ziółkowska

submission deadline 25 Sep 2025 | Viewed by 130 | Submission Open

Keywords: congenital disorders; rare diseases; next-generation sequencing; whole-exome sequencing (WES); whole-genome sequencing (WGS); array comparative genomic hybridization (aCGH); prenatal testing; postnatal testing

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Harnessing Multi-Omics Approaches to Unravel Plant–Microbe Interactions in Cultivated Plants: Implications for Climate Resilience and Sustainable Agriculture

edited by Samathmika Ravi,

Maria Cristina Della Lucia

and