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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Gastrointestinal Disorders (FGIDs): Diagnosis and Pathophysiology, Second Edition

edited by Gengqing Song

submission deadline 31 Jan 2026 | 4 articles | Viewed by 23635 | Submission Open

Keywords: functional gastrointestinal disorders; diagnosis; treatment approach; ROME criteria

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Inflammatory Pathologies

edited by Uday Nagesh Shivaji

submission deadline 31 Jan 2026 | 7 articles | Viewed by 19742 | Submission Open

Keywords: systemic chronic inflammation; biomarkers of inflammation; imaging in inflammatory pathology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis of Cardio-Thoracic Diseases

edited by Tilman Emrich

submission deadline 31 Jan 2026 | 9 articles | Viewed by 19291 | Submission Open

Keywords: cardiac disease; aortic disease; lung disease; computed tomography; magnetic resonance imaging; echocardiography; quantitative imaging; multiparametric imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in the Diagnosis and Management of Cancer/Tumors

edited by

Damiano Caruso

submission deadline 31 Jan 2026 | 5 articles | Viewed by 18944 | Submission Open

Keywords: oncologic imaging; cancer imaging; MRI; CT; X-ray; machine learning; radiodiagnostics; theranostics

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in the Diagnosis, Prognosis, and Management of Urinary Disease

edited by

Nicola Longo

and

Massimiliano Creta

submission deadline 31 Jan 2026 | 8 articles | Viewed by 18777 | Submission Open

Keywords: urinary disease; diagnosis; prognosis; kidney disease; prostate disease; malignant diseases like kidney cancer; bladder cancer and prostate cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis of Otorhinolaryngology

edited by Nina Gale,

Primož Strojan

and Robert Šifrer

submission deadline 31 Jan 2026 | 7 articles | Viewed by 17861 | Submission Open

Keywords: head and neck cancer; otorhinolaryngology; symptoms and clinical signs

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Disease Prediction

edited by

Chi-Chang Chang

, Osman Hayran and Chalong Cheewakriangkrai

submission deadline 31 Jan 2026 | 5 articles | Viewed by 15430 | Submission Open

Keywords: early diagnostics; medical big data analytics; intelligent diagnostic models in public health; survival analysis and health hazard evaluations; machine learning and generative intelligence; intelligent digital twins; automated/intelligent laboratory recommendation systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

AI-Assisted Diagnostics in Telemedicine and Digital Health

edited by

Joseph Finkelstein

submission deadline 31 Jan 2026 | 4 articles | Viewed by 12754 | Submission Open

Keywords: AI; machine learning; deep learning; image analysis; digital health; healthcare; telemedicine; disease diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostic Imaging of Prostate Cancer

edited by

Po-Fan Hsieh

submission deadline 31 Jan 2026 | 6 articles | Viewed by 11041 | Submission Open

Keywords: prostate cancer imaging; multiparametric MRI; PET/CT in prostate cancer; targeted radionuclide imaging; advanced imaging techniques; image-guided interventions for prostate cancer

(This special issue belongs to the Section Medical Imaging and Theranostics)

OCT and OCTA Assessment of Retinal and Choroidal Diseases

edited by Andrei Theodor Bǎlǎşoiu and

Ovidiu Zlatian

submission deadline 31 Jan 2026 | 4 articles | Viewed by 10735 | Submission Open

Keywords: optical coherence tomography; optical coherence tomography angiography; diabetic retinopathy; age related macular degeneration; retinal vascular diseases.

(This special issue belongs to the Section Biomedical Optics)

Hypertension: Diagnosis and Management

edited by

Luigi Marzano

submission deadline 31 Jan 2026 | 4 articles | Viewed by 10032 | Submission Open

Keywords: hypertension; blood pressure; diagnosis; management; cardiovascular diseases; therapeutic targets; treatment strategies; lifestyle modifications; patient education; adherence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Soft Tissue Sarcoma: From Diagnosis to Prognosis

edited by

Consolato M. Sergi

submission deadline 31 Jan 2026 | 3 articles | Viewed by 9341 | Submission Open

Keywords: soft tissue; mesenchyme; bone; pathogenesis; miRNA; imaging; diagnosis; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Tool and Healthcare in Emergency Medicine

edited by

Arian Zaboli

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7684 | Submission Open

Keywords: emergency medicine; risk stratification; scoring systems; emergency care innovation; low-risk patient exclusion; patients safety in acute care; critical condition biomarkers; triage; decision support system

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Urinary Tract Infections: Advances in Diagnosis and Management

edited by

Paul Froom

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7674 | Submission Open

Keywords: urinary tract infections; diagnosis; management; antimicrobial therapy; urinalysis; urine culture; recurrent UTI; asymptomatic bacteriuria

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Clinical Anatomy and Diagnosis in 2025

edited by Ji-Hyun Lee

submission deadline 31 Jan 2026 | 5 articles | Viewed by 6987 | Submission Open

Keywords: anatomy; advanced anatomy; anatomical development; anatomy for diagnostic methods; anatomical research innovation; mechanisms of anatomical pathogenesis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025

edited by

Fabrizio Guarracini

and

Patrizio Mazzone

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6853 | Submission Open

Keywords: atrial fibrillation; ventricular tachycardia; cardiac devices; cardiac electrophysiology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Deep Learning in Biomedical Image and Signal Processing: Recent Advancements and Applications

edited by Narinder Singh Punn

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6519 | Submission Open

Keywords: deep learning; biomedical image; signal processing; multimodal data fusion; explainable AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Prognosis of Hematological Disease

edited by Sapha Shibeeb

submission deadline 31 Jan 2026 | 4 articles | Viewed by 6394 | Submission Open

Keywords: hematological diseases; leukaemia; molecular diagnostics; next-generation sequencing (NGS); precision medicine; predictive biomarkers; AI-assited diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Dental Imaging, Oral Diagnosis, and Forensic Dentistry

edited by

Anastasia Mitsea

, Christos Angelopoulos and Aliki Rontogianni

submission deadline 31 Jan 2026 | 4 articles | Viewed by 5921 | Submission Open

Keywords: automated segmentation; neural networks in dentistry; digital intraoral scanning; radiographic/surgical guides; virtual reality in dental imaging; 3D surgical stimulation; 3D facial reconstruction; forensic odontology; forensic dentistry

(This special issue belongs to the Section Medical Imaging and Theranostics)

Musculoskeletal Imaging in Clinical Practice: From Detection to Decision-Making

edited by

Seul Ki Lee

submission deadline 31 Jan 2026 | 5 articles | Viewed by 4966 | Submission Open

Keywords: musculoskeletal imaging; dual-energy CT; quantitative MRI; musculoskeletal tumors; degenerative diseases; fractures; sport injuries; spine; preoperative planning; postoperative imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis, Treatment, and Prognosis of Breast Cancer

edited by

Marko Buta

submission deadline 31 Jan 2026 | 4 articles | Viewed by 4836 | Submission Open

Keywords: breast cancer diagnosis; molecular profiling; artificial intelligence; targeted therapy; immunotherapy; treatment strategies; prognostic markers; triple-negative breast cancer

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Gastrointestinal Endoscopy: From Diagnosis to Therapy

edited by Cristiano Spada and Daniele Salvi

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4424 | Submission Open

Keywords: gastrointestinal endoscopy; therapeutic endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); artificial intelligence; small bowel capsule endoscopy; bariatric endoscopy

(This special issue belongs to the Section Biomedical Optics)

Advances in Precision Diagnosis of Head and Neck Tumors: From Clues to Clarity

edited by

Alfio Ferlito

and

Orlando Guntinas-Lichius

submission deadline 31 Jan 2026 | 1 articles | Viewed by 4340 | Submission Open

Keywords: head and neck cancer; screening; radiomics; human papillomavirus; liquid biopsy; de-escalation; clinical guidelines; sentinels node; quality of life

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis and Management of Hematologic Malignancies

edited by

Ankur Varma

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4253 | Submission Open

Keywords: acute myeloid leukemia; chronic myeloid leukemia; myelodysplastic syndrome; myeloproliferative neoplasm; Hodgkin's lymphoma; non-Hodgkin's lymphoma; acute lymphocytic leukemia; chronic lymphocytic leukemia; bone marrow failure syndrome; juvenile myelomonocytic leukemia

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diagnosis, Prognosis and Management of Cardiovascular Disease in Patients with Rheumatic Conditions

edited by

Patrick H. M. C. Dessein

Miguel Angel Gonzalez-Gay

and

Iván Ferraz-Amaro

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3834 | Submission Open

Keywords: rheumatoid arthritis; rheumatic conditions; cardiovascular risk factors; atherosclerosis; left ventricular structure and function; arterial function; cardiovascular events; ischemic heart disease; ischemic stroke; heart failure; peripheral vascular disease; venous thrombotic disease; cardiovascular drugs; antirheumatic agents

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Laboratory Diagnosis in Microbial Diseases, 3rd Edition

edited by

Hsin-Yao Wang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3765 | Submission Open

Keywords: genomics; proteomics; diagnostics; infections

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Gastrointestinal Surgery: Diagnosis and Management in 2025

edited by

Federico Selvaggi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3401 | Submission Open

Keywords: gastrointestinal trauma; oligometastatic disease; mesorectal metastasis; lymphnode metastasis; minimally invasive surgical therapy; endoscopic diagnosis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Optical Coherence Tomography in 2025

edited by

Yan Li

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2918 | Submission Open

Keywords: OCT; velocimetry; angiogram; optical coherence elastography (OCE); multimodal imaging

(This special issue belongs to the Section Biomedical Optics)

Imaging in Esophageal Squamous Cell Cancer

edited by Gad Marom

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2647 | Submission Open

Keywords: esophageal squamous cell carcinoma (ESCC); FDG-PET/CT; tumor detection; diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Gynecological and Pediatric Imaging

edited by

Gabriele Masselli

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2377 | Submission Open

Keywords: gynecological imaging; pediatric imaging; obstetrics imaging; magnetic resonance imaging (MRI); computed tomography (CT); ultrasound; early detection; cancer; congenital anomalies; treatment response; outcome assessment

(This special issue belongs to the Section Medical Imaging and Theranostics)

Opportunities in Laboratory Medicine in the Era of Genetic Testing

edited by

Fernanda De-Paris

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2279 | Submission Open

Keywords: laboratory medicine; genetic testing; molecular diagnostics; personalized medicine; clinical decision-making; infectious disease diagnosis; precision oncology

(This special issue belongs to the Section Clinical Laboratory Medicine)

Pathogenesis and Early Diagnosis of HPV-Related Cancers and Pre-Cancers

edited by

Anna Daniela Iacobone

and

Marta Tagliabue

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2262 | Submission Open

Keywords: HPV-related cancer; molecular diagnostics; precancerous lesions; biomarkers; early detection; cervical cancer; anal cancer; oropharyngeal cancer; prognostic factors; HPV genotyping

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in the Diagnosis and Management of Respiratory Disease: From Biomarkers to Treatment Decisions

edited by

Konstantinos Kostikas

and

Athena Gogali

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2259 | Submission Open

Keywords: respiratory biologics; bronchoscopy; airways disease; exhaled biomarkers; artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

The Future of Cardiac Imaging in the Diagnosis, 2nd Edition

edited by

Grigorios Korosoglou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2236 | Submission Open

Keywords: cardiovascular imaging; diagnosis and management; early detection; risk stratification; emerging technologies

(This special issue belongs to the Section Medical Imaging and Theranostics)

Gynecological Cancer: Diagnosis and Screening

edited by

Daniela-Cristina Stefan

and Marius Alexandru Moga

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2044 | Submission Open

Keywords: gynaecological cancers ; diagnoses gynecological cancers ; screening gynecological cancers; global gynecological cancers ; cancer equity ; innovative approaches to gynecological cancers ; gynaecological cancers outcome ; global pathology gynecological cancers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Critical Ultrasound in Newborns/Children

edited by

Jing Liu

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1902 | Submission Open

Keywords: lung ultrasound; pulmonary ultrasound; point-of-care lung ultrasound; newborn infants; neonates; lung diseases; pneumonia; ventilator-associated pneumonia; respiratory distress syndrome; meconium aspiration syndrome; pulmonary hemorrhage; bronchopulmonary dysplasia; tracheobronchial pneumonia; congenital pulmonary malformation; pleural effusion; pneumothorax; pulmonary edema

(This special issue belongs to the Section Medical Imaging and Theranostics)

Novel Advances in Allergy Diagnosis

edited by

Zenon Brzoza

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1870 | Submission Open

Keywords: allergic diseases; allergy diagnosis; biomarker

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis, Treatment and Management of Eye Diseases, Third Edition

edited by

Simona Delia Nicoara

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1651 | Submission Open

Keywords: optical coherence tomography; artificial intelligence; gene therapy; nanotechnology; stem cells; vitreo-retinal surgery; corneal transplantation; minimally invasive glaucoma surgery; cataract surgery; retinopathy of prematurity

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Ultrasound in the Diagnosis and Management of Skin Diseases—2nd Edition

edited by

Joanna Czajkowska

Norbert Kiss

and Miklós Gyöngy

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1601 | Submission Open

Keywords: skin diseases; ultrasound; skin cancer; machine learning; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Cardiovascular Diseases: Innovations in Diagnosis and Management

edited by Hisao Hara

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1469 | Submission Open

Keywords: myocardial infarction; biomarker; prognosis; coronary risk; residual risk; prognosis prediction

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Biomarkers of Urological Diseases

edited by

Martin Pejchinovski

and

Jochen Metzger

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1460 | Submission Open

Keywords: proteomics; biomarkers; diagnosis; prediction; treatment; clinical application; technical advances

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Genetic Diagnosis of Rare Neurological Disorders: Advances, Challenges, and Clinical Impact

edited by

Georgia Xiromerisiou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1441 | Submission Open

Keywords: rare neurological disorders; genetic diagnosis; neurogenetics; next-generation sequencing; genotype– phenotype correlation; molecular diagnostics; clinical impact; personalized medicine; translational research; undiagnosed diseases

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Advances in Clinical Biochemistry, 2nd Edition

edited by Yu Chen

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1425 | Submission Open

Keywords: clinical biochemistry; medical diagnosis; biomarkers; proteomic profiling; metabolomic profiling; high throughput technologies

(This special issue belongs to the Section Clinical Laboratory Medicine)

Recent Progress in Abdominal Ultrasound

edited by Andrea Boccatonda,

Antonio Corvino

and

Giulio Cocco

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1394 | Submission Open

Keywords: ultrasound; abdomen; CEUS; doppler; bowel

(This special issue belongs to the Section Medical Imaging and Theranostics)

Multimodal Cardiac Imaging: Diagnostic and Prognostic Advances

edited by

Lucia La Mura

and Ciro Santoro

submission deadline 31 Jan 2026 | Viewed by 1382 | Submission Open

Keywords: cardiovascular imaging; cardiac CT; cardiac magnetic resonance; cardiac MRI; echocardiography; multimodality cardiovascular imaging; advanced echocardiography

(This special issue belongs to the Section Medical Imaging and Theranostics)

New Advances in Retinal Imaging

edited by

Rodolfo Mastropasqua

and

Maria Ludovica Ruggeri

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1370 | Submission Open

Keywords: retina; vitreoretinal diseases; inherited retinal dystrophies; diabetic retinopathy; age-related macular degeneration; retinal detachment; optical coherence tomography; imaging

(This special issue belongs to the Section Biomedical Optics)

New Aspects of CTC Research for Basic Medicine and Clinical Application

edited by Hayao Nakanishi

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1096 | Submission Open

Keywords: CTC; metastasis; mobilization; cluster heterogeneity; routine blood test; genetic analysis; CTC organoid

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Diabetes Mellitus: Clinical Diagnostics and Management

edited by

Syed M. Shahid

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1010 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; precision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Breast Diagnostics

edited by Takouhie Catherine Maldjian, Jessica Leung, Mary M. Salvatore and Judy Yee

submission deadline 31 Jan 2026 | 1 articles | Viewed by 945 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; breast imaging; breast cancer; breast cancer prognosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Clinical and Interventional Gastroenterology

edited by

Antonio Facciorusso

and

Eyad Gadour

submission deadline 31 Jan 2026 | 1 articles | Viewed by 912 | Submission Open

Keywords: diagnostic endoscopy; AI in gastroenterology; biomarker discovery; capsule endoscopy; confocal laser endomicroscopy; early cancer detection; functional GI disorders; molecular diagnostics; non-invasive imaging; microbiome analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

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