Imaging in Esophageal Squamous Cell Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 781

Special Issue Editor


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Guest Editor
Department of General Surgery, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 12000, Israel
Interests: esophageal squamous cell carcinoma (ESCC); FDG-PET/CT

Special Issue Information

Dear Colleagues,

This Special Issue, titled "Imaging in Esophageal Squamous Cell Cancer", emphasizes the diagnostic capabilities of various imaging modalities in detecting and staging esophageal squamous cell carcinoma (ESCC). It showcases the latest research advancements in the field, emphasizing the crucial role of imaging in the early detection, precise localization, and accurate staging of this aggressive malignancy. The articles delve into the diagnostic accuracy and clinical utility of techniques, such as high-resolution computed tomography (CT), endoscopic ultrasound (EUS) with fine-needle aspiration, and positron emission tomography–computed tomography (PET-CT), in identifying tumor extent, assessing lymph node involvement, and detecting distant metastases. This Special Issue also explores the emerging role of advanced imaging techniques, including diffusion-weighted MRI and functional imaging methods, in providing additional diagnostic information that can guide personalized treatment planning. Overall, this Special Issue highlights the importance of comprehensive imaging strategies for optimizing the diagnosis and subsequent management of ESCC patients.

Dr. Gad Marom
Guest Editor

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Keywords

  • esophageal squamous cell carcinoma (ESCC)
  • FDG-PET/CT
  • tumor detection
  • diagnosis

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Published Papers (1 paper)

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Research

10 pages, 562 KiB  
Article
PET/CT and MR Improve Interobserver Agreement in Primary Tumor Determination for Radiotherapy in Esophageal Squamous Cell Cancer
by Ajra Secerov-Ermenc, Primoz Peterlin, Vaneja Velenik, Ana Jeromen-Peressutti, Jasna But-Hadzic, Franc Anderluh and Barbara Segedin
Diagnostics 2025, 15(6), 690; https://doi.org/10.3390/diagnostics15060690 - 11 Mar 2025
Viewed by 442
Abstract
Background/Objectives: The aim of the study was to evaluate interobserver variability in the determination of the primary tumor for radiotherapy treatment planning in esophageal squamous cell carcinoma (ESCC). Methods: Sixteen patients with locally advanced ESCC were included in the analysis. In [...] Read more.
Background/Objectives: The aim of the study was to evaluate interobserver variability in the determination of the primary tumor for radiotherapy treatment planning in esophageal squamous cell carcinoma (ESCC). Methods: Sixteen patients with locally advanced ESCC were included in the analysis. In all patients positron emission tomography with computed tomography (PETC/CT) and magnetic resonance (MR) scans for radiotherapy planning were performed. Five experienced radiation oncologists delineated the primary tumor based on CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR. Mean tumor volumes were calculated for each patient and imaging modality. The generalized conformity index (CIgen) was calculated to assess agreement in tumor determination. Results: The mean tumor volumes and CIgen for CT alone, MR alone, PET/CT, CT with fused MR and PET/CT with fused MR were 33.1 cm3, 30.2 cm3, 38.1 cm3, 31.9 cm3, 36.2 cm3 and 0.59, 0.64, 0.66, 0.63, 0.71, respectively. CIgen was significantly higher using PET/CT with fused MR compared to CT (p < 0.001) and PET/CT (p = 0.002) and using PET/CT compared to CT (alone) (p = 0.003). Conclusions: Our study showed higher agreement in primary tumor determination in ESCC using PET/CT compared to CT alone. Higher agreement was also found using PET/CT with fused MR compared to CT alone and PET/CT. Full article
(This article belongs to the Special Issue Imaging in Esophageal Squamous Cell Cancer)
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