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Diagnostics
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Novel Advances in Allergy Diagnosis
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Novel Advances in Allergy Diagnosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: closed (31 January 2026) | Viewed by 2776

Special Issue Editor

Prof. Dr. Zenon Brzoza

E-Mail Website
Guest Editor
Department of Internal Diseases, Allergology, Endocrinology and Gastroenterology, Institute of Medical Sciences, University of Opole, 45-401 Opole, Poland
Interests: urticaria; angioedema; allergic diseases; asthma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to introduce the Special Issue, “Novel Advances in Allergy Diagnosis”, in the journal Diagnostics. The Special Issue will focus on the latest developments and innovations in diagnosing allergic diseases and explore the significance of an accurate diagnosis in guiding effective treatment strategies and improving patient outcomes. We aim to publish research results on a range of novel diagnostic techniques, including the development of novel diagnostic tools and techniques, such as immunoassay methods, molecular allergy diagnostics, and bioinformatics approaches that have significantly improved the accuracy and reliability of allergy testing. In addition, we also welcome your work on artificial intelligence and machine learning techniques, biomarkers and proteomic profiling, point-of-care testing, and wearable devices in allergy diagnosis and management. We look forward to receiving your contributions.

Prof. Dr. Zenon Brzoza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • allergic diseases
  • allergy diagnosis
  • biomarker

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Published Papers (2 papers)

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Research

8 pages, 495 KB  
Article
Can the Control of Chronic Spontaneous Urticaria Symptoms Depend on the Stress-Coping Styles?
by Marzena Pluta-Kubicz, Edyta Jura-Szołtys, Radosław Gawlik, Magdalena Feusette, Robert Okuniewicz and Zenon Brzoza
Diagnostics 2025, 15(23), 2965; https://doi.org/10.3390/diagnostics15232965 - 22 Nov 2025
Viewed by 1244
Abstract
Background: The symptoms of chronic spontaneous urticaria can be exacerbated or even induced by psychological stress. Assessing the severity of symptoms using the recommended Urticaria Control Test is an important diagnostic step before deciding on the type of pharmacological treatment to be used. [...] Read more.
Background: The symptoms of chronic spontaneous urticaria can be exacerbated or even induced by psychological stress. Assessing the severity of symptoms using the recommended Urticaria Control Test is an important diagnostic step before deciding on the type of pharmacological treatment to be used. Due to the possibility of urticaria symptoms affecting patient’s emotional condition, the authors attempted to analyze if the way of coping with stress has an impact on urticaria symptom control as assessed with this questionnaire. Methods: The study included 61 (37 female; 60,6%;) patients with symptoms of chronic spontaneous urticaria without other coexisting diseases. All patients were treated with antihistamines. In the analyzed group of patients, the Urticaria Control Test and the Polish version of Endler and Parker’s Coping Inventory for Stressful Situations questionnaire were conducted. Results: The average score on the Urticaria Control Test in the analyzed group was 8.5 (±3.9) points. In our group, the most common coping style was a mixed style based on emotions and avoidance—32 (53%) respondents. Next, 11 (18%) patients reported an emotion-based style. A task-oriented style of coping with stress was observed in 8 (13%) respondents. In the study group, we found no statistical significance in the correlation between the UCT results and the patient’s coping style. Conclusions: Emotions play a significant role as a stress-coping style in chronic spontaneous urticaria patients. The lack of relation found between the Urticaria Control Test result and the Coping Inventory for Stressful Situations questionnaire confirms the objective usefulness of the Urticaria Control Test in assessing the control of spontaneous urticaria. Full article
(This article belongs to the Special Issue Novel Advances in Allergy Diagnosis)
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11 pages, 614 KB  
Article
Phenotypes of Food Allergies in Patients with Atopic Dermatitis Aged Under 24 Months: A Multicenter Study
by Mujde Tuba Cogurlu, Metin Aydogan, Ozlem Cavkaytar, Pinar Uysal, Hazal Cansu Culpan, Nalan Yakici, Zeynep Hizli Demirkale, Erdem Topal, Hasan Yuksel, Sezin Aydemir, Nursen Cigerci Gunaydin, Cigdem Aydogmus, Sukru Cekic, Emre Akkelle, Tuba Tuncel, Isil Eser Simsek, Mustafa Arga, Zeynep Ülker Altinel, Fatih Kaplan, Ayca Kiykim, Ayse Suleyman, Nermin Guler, Esra Yucel, Haluk Cokugras, Nihat Sapan, Hikmet Tekin Nacaroglu, Adem Yasar, Yakup Yesil, Gonca Hancioglu, Recep Sancak, Mehmet Sarper Erdogan, Oner Ozdemir, Cevdet Ozdemir and Fazil Orhanadd Show full author list remove Hide full author list
Diagnostics 2025, 15(20), 2656; https://doi.org/10.3390/diagnostics15202656 - 21 Oct 2025
Viewed by 1140
Abstract
Background: Atopic dermatitis (AD) and food allergy (FA) are common allergic diseases in early childhood. AD may be concomitant with FA, particularly in young children. Although studies report the prevalence of FA in children with AD, there is insufficient data regarding different phenotypes [...] Read more.
Background: Atopic dermatitis (AD) and food allergy (FA) are common allergic diseases in early childhood. AD may be concomitant with FA, particularly in young children. Although studies report the prevalence of FA in children with AD, there is insufficient data regarding different phenotypes of FA. Objective: The aim of our research was to determine the prevalence and clinical predictors of different phenotypes of concomitant FA in children with AD. Methods: This cross-sectional multicenter study included patients younger than 24 months old diagnosed with AD, recruited from 14 pediatric allergy centers. Patients were categorized into two groups using skin testing, allergen-specific IgE, and ultimately food challenge testing (FCT): those with FA and those without. Individuals with FA were classified into three distinct phenotypes: IgE-mediated, non-IgE-mediated, and concurrent IgE- and non-IgE-mediated. Results: The data of 530 children [59% male, median-age 7 months (IQR: 5–11)] were analyzed. IgE-mediated FA was found in 28.1% of participants, whereas 22.4% (n = 119/530) exhibited non-IgE-mediated FA. Concurrent IgE- and non-IgE-mediated FA was reported in 12.1% (n = 64/530) of patients. Cow’s milk (69.6%) and egg-white (68.9%) were identified as the most prevalent allergens. Cow’s milk was primarily responsible for non-IgE-mediated and egg-white for IgE-mediated FA. The most significant predictors of FA were severe AD and the presence of blood in stool with odds ratios of 8.25 (95% Cl: 3.04–22.39) and 10.04 (95% CI: 2.03–49.59), respectively (p < 0.01) (p < 0.005). Conclusions: The study’s findings indicate that children with early-onset and mild-to-moderate AD deserve to be comprehensively assessed for FA symptoms. The most significant indicators of concomitant FA in AD patients were the presence of blood in stool and severe AD. It is important to consider that those who exhibit IgE-mediated FA may also have concurrent non-IgE-mediated FA. We underline that it is important to consider that children with AD who exhibit IgE-mediated FA may also have concurrent non-IgE-mediated FA. Addressing these symptoms may assist healthcare practitioners in clinical practice to improve the quality of care for AD patients having FA. Full article
(This article belongs to the Special Issue Novel Advances in Allergy Diagnosis)
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