OCT and OCTA Assessment of Retinal and Choroidal Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Biomedical Optics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1159

Special Issue Editors


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Guest Editor
Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: optical coherence tomography; retinal diseases; choroidal diseases

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Guest Editor
1. Medical Laboratory, County Clinical Emergency Hospital of Craiova, 200642 Craiova, Romania
2. Microbiology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: ophthalmology; antibiotic resistance; bacterial and viral infections; testing of antimicrobial activity of various compounds
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Special Issue Information

Dear Colleagues,

In the field of medicine has taken significant steps in the recent decades due to technology development, and the ophthalmology sector is no exception.

In just a few years, optical coherence tomography (OCT) has become the “gold standard” of screening and diagnosis for ocular diseases as a non-invasive imaging method. Optical coherence tomography angiography (OCTA) is in its early days but it is believed that it will replace invasive imaging methods such as fluorescein fundus angiography in years to come. In addition to modern investigations, modern therapies have also emerged, so morbidity due to retinal and choroidal diseases has decreased significantly.

In spite of the recent improvements in diagnosis and treatment, these conditions still represent the leading causes of blindness worldwide.

We seem to know a lot and we seem to do a lot, but there is still a major burden of irreversible vision loss among patients affected by retinal and choroidal conditions. Therefore, sharing knowledge and analyzing pathologies from different angles represents the key to further improvement.

This Special Issue is centered around, but not exclusively, the following conditions:

- Vascular retinal diseases;

- Diabetic retinopathy;

- Inherited fundus diseases;

- Dry age-related macular degeneration and geographic atrophy;

- Wet age-related macular degeneration;

- Retinal/choroidal malignancies;

- Retinal/choroidal involvement in general diseases.

Dr. Andrei Theodor Bǎlǎşoiu
Dr. Ovidiu Zlatian
Guest Editors

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Keywords

  • optical coherence tomography
  • optical coherence tomography angiography
  • diabetic retinopathy
  • age related macular degeneration
  • retinal vascular diseases.

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Published Papers (1 paper)

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13 pages, 10701 KiB  
Case Report
Characterization of Syphilitic Chorioretinitis as a White Dot Syndrome with Multimodal Imaging: Case Series
by Robert J. Contento, Neha Gupta and Mark P. Breazzano
Diagnostics 2025, 15(3), 369; https://doi.org/10.3390/diagnostics15030369 - 4 Feb 2025
Viewed by 815
Abstract
Background/Objectives: To investigate the role of multimodal imaging, including ultra-widefield fundus autofluorescence (UWFAF), in diagnosing and monitoring syphilitic chorioretinitis, focusing on the detection of placoid appearance and white dots/spots. We aim to classify syphilitic chorioretinitis as a white dot syndrome, given evident [...] Read more.
Background/Objectives: To investigate the role of multimodal imaging, including ultra-widefield fundus autofluorescence (UWFAF), in diagnosing and monitoring syphilitic chorioretinitis, focusing on the detection of placoid appearance and white dots/spots. We aim to classify syphilitic chorioretinitis as a white dot syndrome, given evident features in the context of recent case reports and previously unavailable multimodal imaging. Methods: This single-institution study was conducted as a consecutive, observational case series. Five eyes from three patients were diagnosed with syphilitic chorioretinitis using multimodal imaging, including ultra-widefield pseudocolor fundus photography and intravenous fluorescein angiography, UWFAF, and swept-source optical coherence tomography, upon laboratory results. Results: In all five eyes with serologically confirmed syphilitic chorioretinitis, UWFAF revealed hyperautofluorescent white dots and spots scattered in the fundus, a finding minimally apparent with fluorescein angiography. Two eyes did not show evidence of classic placoid lesions. The hyperautofluorescence resolved after standard neurosyphilis treatment with intravenous course of penicillin. Conclusions: The presence of dots and spots identified through UWFAF may indicate syphilitic chorioretinitis and support its classification as a white dot syndrome. Based on the presence of hyperautofluorescent placoid lesions in some but not all cases with dots and spots, this study highlights the utility of multimodal imaging, including the more recent availability of UWFAF, in diagnosing syphilitic chorioretinitis. Future research is needed to determine whether the dots and spots in syphilitic chorioretinitis represent direct spirochete infiltration or a secondary inflammatory response. Full article
(This article belongs to the Special Issue OCT and OCTA Assessment of Retinal and Choroidal Diseases)
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