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Diagnostics
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Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025
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Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1546

Special Issue Editors

Dr. Fabrizio Guarracini

E-Mail Website
Guest Editor
De Gasperis Cardio Center and Transplant Center, Niguarda Hospital, 20126 Milan, Italy
Interests: cardiac electrophysiology; cardiac devices; ventricular tachycardia; atrial fibrillation; left atrial appendage closure
Special Issues, Collections and Topics in MDPI journals
Dr. Patrizio Mazzone

E-Mail Website
Guest Editor
De Gasperis Cardio Center and Transplant Center, Niguarda Hospital, 20126 Milan, Italy
Interests: ventricular arrhythmias; sudden death; genetics; electrophysiology study; ablation of ventricular arrhythmias
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The diagnosis and treatment of cardiac arrhythmias are constantly evolving in daily clinical practice. Patients with cardiac arrhythmias such as atrial fibrillation or ventricular tachycardia often require advanced multidisciplinary assessments and treatments with the collaboration of cardiac surgeons for hybrid ablations or hemodynamic support. The use of the latest technologies in the field of cardiac electrophysiology and cardiac devices has allowed for safer treatments with better results in the follow-up of patients affected by different heart diseases. This Special Issue “Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025” will cover a selection of recent research topics and updated manuscripts on the innovations in the field of interventional and pharmacological treatment of cardiac arrhythmias.

Dr. Fabrizio Guarracini
Dr. Patrizio Mazzone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atrial fibrillation
  • ventricular tachycardia
  • cardiac devices
  • cardiac electrophysiology

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Related Special Issue

Published Papers (2 papers)

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Research

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12 pages, 498 KiB  
Article
Inflammatory Markers and Postoperative New-Onset Atrial Fibrillation: Prognostic Predictions of Neutrophil Percent to Albumin Ratio in Patients with CABG
by Faruk Serhatlioglu, Yucel Yilmaz, Oguzhan Baran, Halis Yilmaz and Saban Kelesoglu
Diagnostics 2025, 15(6), 741; https://doi.org/10.3390/diagnostics15060741 - 16 Mar 2025
Viewed by 420
Abstract
Background/Objectives: Postoperative new-onset atrial fibrillation (AF) (PNOAF) is the most common complication after coronary artery bypass graft (CABG), and its incidence has been reported as up to 50% in studies. In this study, we investigated whether there was a relationship between PNOAF and [...] Read more.
Background/Objectives: Postoperative new-onset atrial fibrillation (AF) (PNOAF) is the most common complication after coronary artery bypass graft (CABG), and its incidence has been reported as up to 50% in studies. In this study, we investigated whether there was a relationship between PNOAF and the neutrophil percentage to albumin ratio (NPAR) levels after on-pump CABG. Methods: A total of 454 patients who underwent CABG were included in the study. NPAR was calculated by dividing the neutrophil count by the albumin value. Results: It was determined that 93 patients developed PNOAF (20.4%). When the patient groups that developed and did not develop PNOAF were compared in terms of laboratory findings, C-reactive protein (CRP) values (4.0 mg/L (2.8–7.9) vs. 2.9 mg/L (1.1–6.7), <0.001), neutrophil/lymphocyte ratio (NLR) (2.2 (1.2–4.2) vs. 1.4 (0.7–3.1), <0.001), platelets-to-lymphocyte ratio (112 (72–177) vs. 92 (69–122), <0.001) and NPAR (2.29 (1.68–3.8) vs. 1.09 (0.79–1.81), <0.001), were found to be statistically significantly higher in the group that developed PNOAF. ROC analysis showed that the cut-off value for NPAR for the development of PNOAF was 1.86 with 78% sensitivity and 72% specificity (area under the ROC curve = 0.778, 95% CI (0.728–0.828), p < 0.001). Conclusions: NPAR, which can be detected by a simple venous blood test, has shown a strong predictive value for PNOAF in patients with CABG. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025)
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Review

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16 pages, 272 KiB  
Review
Anderson–Fabry Disease: An Overview of Current Diagnosis, Arrhythmic Risk Stratification, and Therapeutic Strategies
by Chiara Tognola, Giacomo Ruzzenenti, Alessandro Maloberti, Marisa Varrenti, Patrizio Mazzone, Cristina Giannattasio and Fabrizio Guarracini
Diagnostics 2025, 15(2), 139; https://doi.org/10.3390/diagnostics15020139 - 9 Jan 2025
Cited by 1 | Viewed by 858
Abstract
Anderson–Fabry disease (AFD) is a rare X-linked lysosomal storage disorder characterized by the accumulation of globotriaosylceramide, leading to multi-organ involvement and significant morbidity. Cardiovascular manifestations, particularly arrhythmias, are common and pose a considerable risk to affected individuals. This overview examines current approaches to [...] Read more.
Anderson–Fabry disease (AFD) is a rare X-linked lysosomal storage disorder characterized by the accumulation of globotriaosylceramide, leading to multi-organ involvement and significant morbidity. Cardiovascular manifestations, particularly arrhythmias, are common and pose a considerable risk to affected individuals. This overview examines current approaches to arrhythmic risk stratification in AFD, focusing on the identification, assessment, and management of cardiac arrhythmias associated with the disease. We explore advancements in diagnostic techniques, including echocardiography, cardiac MRI, and ambulatory ECG monitoring, to enhance the detection of arrhythmogenic substrate. Furthermore, we discuss the role of genetic and biochemical markers in predicting arrhythmic risk and the implications for personalized treatment strategies. Current therapeutic interventions, including enzyme replacement therapy and antiarrhythmic medications, are reviewed in the context of their efficacy and limitations. Finally, we highlight ongoing research and future directions with the aim of improving arrhythmic risk assessment and management in AFD. This overview underscores the need for a multidisciplinary approach to optimize care and outcomes for patients with AFD. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Cardiac Arrhythmias 2025)
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