Diagnostics, Volume 16, Issue 2

In addition to standardized lateral cephalometric radiographs, comprehensive assessment using dental cone-beam computed tomography (CBCT) and CT has become commonplace in the diagnosis and treatment of jaw deformities. Simulation based on cephalometr...

Artificial Intelligence (AI) is a computer science that focuses on developing systems and machines capable of performing tasks that typically require human cognitive abilities. It has widespread applications in medical diagnostics. Its use has led to...

Three-dimensional (3D) reconstruction of ultrasound (US) images represents a novel advancement that has been extensively explored over the past three decades. This technique enables endoscopists to perform more detailed and enhanced visualizations of...

Background: Feigned restriction of shoulder joint movement for secondary gain is clinically relevant and may misdirect care, distort disability determinations, and inflate system costs. Distinguishing feigning from structural pathology and from funct...

Background: Major Depressive Disorder (MDD) is a pervasive psychiatric condition. Electroencephalography (EEG) is employed to detect MDD-specific neural patterns because it is non-invasive and temporally precise. However, manual interpretation of EEG...

Background and Objectives: Accurate breast tumor segmentation in dynamic contrast-enhanced MRI (DCE-MRI) is crucial for treatment planning, therapy monitoring, and quantitative studies of breast cancer response. However, deep learning models often ha...

Background: Aspiration pneumonia (AP) remains a major cause of morbidity and mortality, yet non-invasive tools for monitoring lung injury in preclinical models are limited. Lung ultrasound (LUS) is widely used clinically, but existing murine scoring...

Background/Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype, with limited diagnostic options and no targeted early detection tools. Liquid biopsy represents a minimally invasive approach for detecting tumor-derived molecular...

Sjögren’s syndrome is a chronic autoimmune disease marked by lymphocytic infiltration of the exocrine glands and the development of sicca symptoms, yet some patients also develop extraglandular involvement. Imaging has become relevant for...

Background/Objectives: Globally, one of the most dreadful and rapidly spreading illnesses is skin cancer, and it is acknowledged as a lethal form of cancer due to the abnormal growth of skin cells. Mostly, classifying and diagnosing the types of skin...

Background: Irritable Bowel Syndrome (IBS) is a heterogeneous gastrointestinal disorder characterized by complex brain–gut interactions. Patient Similarity Networks (PSNs) offer a novel approach for exploring this heterogeneity and identifying...

Background/Objectives: Accurate assessment of lymph nodes is of paramount importance for correct cN staging in head and neck cancer; however, it is very time-consuming for radiologists, and lymph node metastases of head and neck cancers may show dist...

Background: With extensive research and development in the past decade, the affordability of Poly (ADP-ribose) polymerase (PARP) inhibitor therapy has drastically improved. Homologous recombination deficiency (HRD), a key biomarker, has been identifi...

Background/Objectives: Ultrasonography (US) is a non-invasive and repeatable examination for evaluating chronic constipation. However, few studies have explored treatment decisions based on rectal US findings. To date, the efficacy and safety of elob...

Objectives: This systematic review aimed to evaluate the effectiveness of currently available methods for the diagnosis and monitoring of skeletal, dental, and soft tissue changes, as well as the adequacy of follow-up protocols, in adolescents and ad...

Point-of-care ultrasound (POCUS) is an essential component of emergency medicine, enabling rapid bedside assessment across a wide spectrum of acute conditions. Its effectiveness, however, remains constrained by operator dependency, variable image qua...

Background/Objectives: Large osteochondral lesions of the talus (OLT) pose a major challenge because their size and depth often exceed the indications for bone marrow stimulation, and durable biological repair remains difficult to achieve. However, e...

Background/Objectives: Atypical femoral fracture (AFF) represents a diagnostic and therapeutic challenge, particularly in autoimmune disease patients receiving long-term bisphosphonate (BP) and glucocorticoid (GC) therapy. Although bilateral AFF is c...

Background and Objectives: Early recognition of life-threatening organ dysfunction is central to modern sepsis frameworks. We systematically reviewed the prognostic performance and clinical utility of the Neonatal Sequential Organ Failure Assessment...

Background/Objectives: Interest in myocardial mapping for cardiac MRI has increased, enabling differentiation of various cardiac diseases through T1, T2, and T2* mapping. This study evaluates the impact of deep learning (DL)-based image reconstructio...

Objectives: This study aimed to compare the predictive performance of the Korean Triage and Acuity Scale (KTAS) and the National Early Warning Score (NEWS) for serious adverse events (SAEs), including mortality and intensive care unit (ICU) admission...

Diagnostic errors have been a critical concern in healthcare, leading to substantial financial burdens and serious threats to patient safety. The Improving Diagnosis in Health Care report by the National Academies of Sciences, Engineering, and Medici...

Background/Objectives: The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare and aggressive subtype characterized by diffuse gland involvement and early cervical lymph node metastasis. Preoperative differentiation from cla...

Background/Objectives: Gunshot wounds in living patients present significant challenges from both a clinical and a forensic perspective. Understanding the exact trajectory of a bullet is crucial not only for guiding treatment but also for providing r...

Background/Objectives: Early detection of hepatocellular carcinoma (HCC), particularly small lesions (<2 cm), which is crucial for curative treatment, remains challenging with conventional liver dynamic computed tomography (LDCT). We aimed to deve...

Recurrent brain tumors—including high-grade gliomas, brain metastases, and aggressive meningiomas—continue to carry a poor prognosis, with high mortality despite therapeutic advances. The aim of this narrative review is to summarize and c...

Background: Pheochromocytoma is a rare adrenal neuroendocrine tumor characterized by excessive catecholamine secretion, which can lead to significant perioperative hemodynamic instability. Despite advances in anesthetic and surgical management, intra...

Background/Objectives: This study seeks to evaluate the clinical characteristics of newly diagnosed male breast cancers within the traditionally underserved Bronx population at risk for poorer health outcomes. Methods: We retrospectively searched our...

Background/Objectives: Syndromic multiplex PCR assays such as BIOFIRE FilmArray^® Pneumonia (PN) panel enable rapid and simultaneous detection of bacterial and viral pathogens in respiratory specimens, improving diagnostic accuracy and patient man...

Background/Objectives: Stool-based GeneXpert testing has become a useful approach for diagnosing pediatric pulmonary tuberculosis (PTB). This study compared two stool-processing methods, centrifugation-based processing (CBP) and simple one-step (SOS)...

Background/Objectives: High-quality bowel preparation is essential for the diagnostic accuracy of colonoscopy, the gold standard for colorectal cancer screening. In our study, we aimed to compare the efficacy and tolerability of three bowel preparati...

Background: Ward patients who experience clinical deterioration are at high risk of mortality. Conventional rapid response systems (RRS) using track-and-trigger protocols have not consistently demonstrated improved outcomes. This study evaluated the...

Background/Objectives: This study provides a systematic benchmark of U-Net–based deep learning models for automatic tooth segmentation in panoramic dental radiographs, with a specific focus on how segmentation accuracy changes as computational...

Background: Epstein–Barr virus (EBV)-related primary splenic tumors are exceptionally rare and encompass a heterogeneous group of entities, including inflammatory pseudotumor (IPT), IPT-like follicular dendritic cell (FDC) tumors or sarcomas, a...

Acute mesenteric ischemia (AMI) is a clinical condition caused by vascular insufficiency, resulting in intestinal damage. Is often underestimated, if not driven by clinical suspicion, due to the non-specific clinical symptoms (usually represented by...

Background/Objectives: Robotic capsule endoscopy (RCE) is an emerging technology that combines magnetically controlled gastric navigation with conventional capsule enteroscopy (CE), enabling a minimally invasive, comprehensive evaluation of the upper...

Background/Objectives: Ultra-low-dose computed tomography (ULD-CT) enables substantial radiation reduction compared with routine low-dose computed tomography (LD-CT), but its quantitative reliability across lung imaging biomarkers remains insufficien...

Background/Objectives: Subjective refraction is the clinical gold standard but is time-consuming and examiner-dependent. Most artificial intelligence (AI)-based approaches rely on specialized imaging or biometric data not routinely available. This st...

The biomarker landscape in rheumatoid arthritis (RA) is evolving from reliance on traditional markers toward integrated, multimodal strategies enabling precision medicine approaches. To critically evaluate emerging biomarkers across serological, cell...

Intraoperative assessment of pancreatic quality, followed by sampling for the potential isolation of Langerhans islets for subsequent autotransplantation, is currently a key component of post-total pancreatectomy diabetes mellitus treatment. The aim...

Background: Differentiating hypophysitis from non-functioning pituitary macroadenomas (NFPMA) remains a clinical and radiological challenge. Both entities present as sellar masses with overlapping features but require distinct therapeutic approaches....

Background/Objectives: Chronic pudendal neuralgia is a relatively rare condition in the general population, with an incidence of 1%. Although diagnosis of pudendal neuralgia is mainly clinical, Magnetic Resonance Imaging (MRI) is commonly performed t...

Background/Objectives: Postmortem microbiology has traditionally been regarded with caution in forensic practice due to concerns related to contamination, bacterial translocation, and postmortem microbial overgrowth. As a result, microbiological find...

Background/Objectives: Sarcopenia (Sp) and obesity (Ob) have significant negative effects on steatotic liver disease (SLD). Here, we examined the effects of sarcopenic Ob (SO) on liver fibrosis in patients with SLD. Methods: We included 811 patients...

Background: Multimodal large language models (MLLMs) integrating multiple AI systems and unimodal large language models (LLMs) represent distinct approaches to clinical decision support. Their comparative performance against human clinical experts in...

Pediatric obesity is a growing public health concern, significantly increasing the risk of metabolic and cardiovascular comorbidities. Background/Objectives: This study aims to explore the burden of obesity, its associated comorbidities, and resting...

Background/Objective: Bitewing radiographs are widely used for evaluating dental caries, restorations, and periodontal status due to their low radiation dose and high image quality. While artificial intelligence–based studies are common for oth...

Background/Objectives: Anti-mGluR1 encephalitis is a rare form of autoimmune encephalitis predominantly manifesting as acute/subacute cerebellar ataxia. We describe a newly diagnosed case series from our center and conduct a comprehensive review of r...

Major traumas result from the application of multiple force components that, in adulthood, can lead to high mortality and morbidity. In forensic practice, pathological consequences arising from the rapid flexion–extension of an adult victim&rsq...

Background: Automated AI-based brain volumetry is increasingly used in clinical practice. T1-weighted sequences (e.g., MPRAGE) are considered the current state-of-the art. However, due to faster acquisition and higher in-plane resolution, 2D anisotro...