Advances in Clinical and Interventional Gastroenterology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 211

Special Issue Editors


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Guest Editor Assistant
1. Multi-Organ Transplant Centre of Excellence, Liver Transplantation Unit, King Fahad Specialist Hospital, Dammam 32253, Saudi Arabia
2. Department of Medicine, Faculty of Medicine, Zamzam University College, Khartoum 11113, Sudan
Interests: gastroenterology; hepatology; hepatobiliary medicine

Special Issue Information

Dear Colleagues,

Gastrointestinal disorders demand precise and minimally invasive diagnostic approaches to optimize patient outcomes. This Special Issue highlights cutting-edge advancements in clinical and interventional gastroenterology, focusing on novel diagnostic modalities such as AI-enhanced endoscopy, advanced imaging techniques (e.g., confocal laser endomicroscopy, capsule endoscopy), and biomarker discovery. Key themes include the early detection of neoplastic and inflammatory conditions, functional GI diagnostics, and the integration of molecular profiling into routine practice. By bridging translational research and clinical application, this Special Issue aims to refine diagnostic accuracy, reduce invasiveness, and personalize patient assessment in gastroenterology.

Dr. Antonio Facciorusso
Guest Editor

Dr. Eyad Gadour
Guest Editor Assistant

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Keywords

  • diagnostic endoscopy
  • AI in gastroenterology
  • biomarker discovery
  • capsule endoscopy
  • confocal laser endomicroscopy
  • early cancer detection
  • functional GI disorders
  • molecular diagnostics
  • non-invasive imaging
  • microbiome analysis

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Published Papers (1 paper)

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Research

13 pages, 1514 KB  
Article
Assessment   of Intra-Individual Variability and Reproducibility in Pancreatic EUS-Guided    Elastography   
by Bogdan Miutescu, Renata Bende, Felix Bende, Adrian Burdan, Eyad Gadour, Ana Maria Ghiuchici, Mohammed Alomar, Calin Burciu, Mohammed Saad AlQahtani, Roxana Sirli, Alina Popescu and Iulia Ratiu
Diagnostics 2025, 15(20), 2601; https://doi.org/10.3390/diagnostics15202601 (registering DOI) - 15 Oct 2025
Abstract
Background: Shear-wave elastography (SWE) performed during endoscopic ultrasound (EUS) is a promising tool for quantifying pancreatic stiffness, but its intra-session reproducibility remains incompletely defined. Methods: In this prospective single-center study, 86 consecutive patients (median age 66 years; 59.3% women) [...] Read more.
Background: Shear-wave elastography (SWE) performed during endoscopic ultrasound (EUS) is a promising tool for quantifying pancreatic stiffness, but its intra-session reproducibility remains incompletely defined. Methods: In this prospective single-center study, 86 consecutive patients (median age 66 years; 59.3% women) referred for diagnostic EUS underwent EUS-guided point SWE. Ten measurements were acquired from a 10 × 15 mm region of interest in the pancreatic body or tail when the breath was held by a single expert operator. Reproducibility was assessed by comparing the first and last five acquisitions; intra-individual variability was expressed as the coefficient of variation (CV). Results: Mean stiffness was 18.5 ± 8.9 kPa (2.31 ± 0.58 m/s). Agreement between early and late measurements was excellent in kPa (ICC = 0.99; r = 0.997; mean bias −0.06 kPa) and moderate in m/s (ICC = 0.61; r = 0.61). The mean CVs were 0.640 for kPa and 0.328 for m/s. Sex, age, and BMI had no significant influence on stiffness or reproducibility. The technical success rate was 97%, with no adverse events. Conclusions: EUS-guided point SWE provides highly reproducible pancreatic stiffness measurements within a single session, particularly when expressed in kPa. Demographic factors do not affect stability, supporting its integration into routine EUS practice. Further multicenter studies are needed to establish pathology-specific cut-offs and confirm clinical relevance. Full article
(This article belongs to the Special Issue Advances in Clinical and Interventional Gastroenterology)
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