Cellular Origin of Glioma: From Triggers to Treatments
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 January 2026 | Viewed by 23
Special Issue Editor
Interests: epigenetics; cancer; brain; drug therapy; genomics; genetics; adenovirus; mouse models; suppressor genes; drug targeting; solid tumours
Special Issue Information
Dear Colleagues,
An aggressive primary brain tumour, glioblastoma (GBM), is the most common cancer of the central nervous system in adults. However, an inability to identify its cell of origin has been a fundamental issue hindering further understanding of the nature and pathogenesis of GBM, as well as the development of novel therapeutic targets. Researchers have hypothesized that GBM arises from the accumulation of somatic mutations in neural stem cells (NSCs) and glial precursor cells that confer selective growth advantages, leading to uncontrolled proliferation. Understanding the cellular origin of gliomas and the lineage hierarchy of GBM is crucial for accurate diagnosis, effective treatment, and patient outcomes.
Dr. Katherine Karakoula
Guest Editor
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Keywords
- glioblastoma
- brain tumour
- tumour heterogeneity
- targeted therapy
- glioma stem cells
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