Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 577
Special Issue Editors
Interests: neurodegenerative diseases; ageing and regeneration; regenerative medicine; oxidative stress
Interests: multiple sclerosis; neurodegenerative diseases
Interests: chronobiology; genetics; oncology; immunology; endocrinology; physio-pathological mechanisms of ageing; complex systems analysis; biological systems modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For this Special Issue, we aim to gather scientific evidence related to the application and potential of regenerative medicine in the treatment of neurodegenerative diseases. Regenerative medicine is a multidisciplinary field based on the endogenous capacity of the living organism to self-repair and restore the functions of damaged tissues and organs. To facilitate and enhance this physiological regenerative process, different therapies and approaches are currently being studied in preclinical and clinical settings for the treatment of acute damage and chronic diseases. Stem cells play a pivotal role. Within the endogenous neural stem cell field, a homeostasis imbalance due to exogenous/endogenous toxic agents, the accumulation of reactive oxygen species (ROS), or impaired signaling pathways can cause neurotoxicity, contributing to chronic inflammation, which can lead to neurodegenerative pathologies and impede regeneration. Regenerative medicine strategies rely on the employment of stem cells, such as neural stem cells, mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), or platelet-rich plasma (PRP), which use a systemic paracrine modality to produce a therapeutic response. Moreover, cell–cell contact may be also required. For example, MSCs can inhibit T-cell proliferation and dampen inflammation through direct contact between the transplanted MSCs and host immune cells. However, the numerous factors released by the healing cells may not only have an immunomodulatory function but also modulate the proliferation and differentiation of endogenous cells, as well as replacing the damaged cells themselves. A better understanding of the molecular mechanisms underlying the neurodegeneration process is necessary in order to improve the efficacy of regenerative medicine strategies.
Dr. Elisabetta Mormone
Dr. Paola Crociani
Prof. Dr. Gianluigi Ubaldo Mazzoccoli
Guest Editors
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Keywords
- inflammation
- iPSCs
- MSCs
- neural stem cells niche
- neurodegeneration
- regenerative medicine
- ROS
- PRP
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