New Advances in Tissue Engineering and Regeneration

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 595

Special Issue Editors


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Guest Editor
RAMSES Laboratory for Personalized Regenerative Medicine for the Musculoskeletal System, Rizzoli Orthopedic Institute, Bologna, Italy
Interests: regenerative medicine; bone tissue regeneration; cartilage regeneration; biomaterials for tissue engineering; osteoporosis

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Guest Editor
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
Interests: bone tissue engineering; 3D printed scaffolds
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Special Issue Information

Dear Colleagues,

Tissue engineering and regenerative medicine represent rapidly advancing fields of biomedical research, aiming to restore, replace, or enhance the function of damaged or diseased tissues.

These interdisciplinary fields combine principles from cell biology, materials science, and bioengineering to develop biologically functional constructs through the combination of scaffolds, cells, and bioactive molecules.

Recent advances have significantly expanded the therapeutic potential of engineered tissues and organoids, such as the use of stem cells, bioactive biomaterials, and bioprinting technologies.

This Special Issue has the intention to highlight the latest innovations, interdisciplinary strategies, and translational efforts in tissue engineering and regeneration, with the final goal of addressing unmet medical needs, focusing on the concept of “from bench to bedside”.

We invite contributions that explore novel biomaterials, advanced fabrication techniques, cell-based therapies that aim to propose solutions for tissue repair and organ regeneration.

We encourage original research articles and reviews that reflect cutting-edge science and technology, with the final goal of accelerating the progress toward effective regenerative therapies.

Dr. Giorgia Borciani
Dr. Giorgia Montalbano
Guest Editors

Manuscript Submission Information

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Keywords

  • tissue regeneration
  • tissue engineering
  • regenerative medicine
  • musculoskeletal tissues
  • biomaterials
  • stem cells
  • 3D bioprinting
  • scaffold design
  • cell therapy
  • organoids
  • translational research

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Published Papers (1 paper)

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Research

19 pages, 6972 KB  
Article
Development and Characterization of a Novel Lineage of Renal Progenitor Cells for Potential Use in Feline Chronic Kidney Disease: A Preliminary Study
by Lara Carolina Mario, Juliana de Paula Nhanharelli, Jéssica Borghesi, Rafaela Rodrigues Ribeiro, Hianka Jasmyne Costa de Carvalho, Thamires Santos da Silva, Mariano del Sol, Rodrigo da Silva Nunes Barreto, Sandra Maria Barbalho and Maria Angelica Miglino
Cells 2025, 14(17), 1395; https://doi.org/10.3390/cells14171395 - 6 Sep 2025
Viewed by 51
Abstract
Chronic kidney disease (CKD) is a common and serious condition in felines. Accordingly, several cell therapies have been studied over the past decades for effective treatments. This study aimed to develop a new lineage of renal progenitor cells for use in cats with [...] Read more.
Chronic kidney disease (CKD) is a common and serious condition in felines. Accordingly, several cell therapies have been studied over the past decades for effective treatments. This study aimed to develop a new lineage of renal progenitor cells for use in cats with CKD. Metanephric and mesonephric progenitor cells were obtained from mesonephros and metanephros tissues of feline conceptuses at four distinct gestational stages. The cultured cells were characterized by their morphology, tumorigenic potential, immunophenotype determined by flow cytometry, and differentiation potential. We then conducted a pilot study in CKD-affected cats, comparing intraperitoneal injections of cultured metanephric progenitor cells (n = 4) to a placebo solution (n = 3). All four cell types exhibited adhesion and colony formation, but showed no tumorigenic potential. Cells tested positive for renal progenitor markers (CD117, Nephron, and WT1), confirming their identity. Treated cats showed no statistically significant differences (p ≤ 0.05) in any of the data analyzed. However, caregivers reported a voluntary increase in appetite after cell administration. Veterinarians confirmed this information during double-blind evaluations conducted after treatment. Although this data are qualitative, no clinical deterioration was observed in cats. Our results suggest that this new lineage of renal progenitor cells did not induce immediate adverse effects, thus supporting its potential for use in cell-based therapies. However, further studies are needed to evaluate its efficacy in treating renal diseases. Full article
(This article belongs to the Special Issue New Advances in Tissue Engineering and Regeneration)
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