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Cells
Special Issues
Adipose-Derived Stem Cells: Current Applications and Future Directions
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Adipose-Derived Stem Cells: Current Applications and Future Directions

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 2925

Special Issue Editor

Prof. Dr. Yasuhito Ishigaki

E-Mail Website
Guest Editor
Medical Research Institute, Kanazawa Medical University, Kahoku 920-0293, Japan
Interests: adipose-derived stem cells; mRNA decay; noncoding RNA; RNA bindings; transcriptome analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cultured adipose-derived stem cells have many advantages over other mesenchymal stem cells and have demonstrated therapeutic efficacy in a variety of areas, including plastic surgery. However, they may not be the perfect cell source of therapy at this time.

Therefore, there is a need to construct new adipose-derived stem cell systems with improved cell culture methods and genetic manipulation. For example, the formation of spheroids and sheets, an improvement in culture media, and the development of new culture substrates are expected to enhance therapeutic outcomes. Moreover, attempts are being made to improve therapeutic efficacy by increasing the secretory capacity of various factors using genetic recombination technology. In addition to the above efforts, this Special Issue aims to include reports of novel therapeutic methods using ADSCs, utilization and purification methods of exosomes, and other cellular secreted products. Based on the above, we aim to provide an argument in this Special Issue for the future use of next-generation adipose-derived stem cells.

Prof. Dr. Yasuhito Ishigaki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell therapy
  • regenerative medicine
  • adipose-derived stem cells (ADSCs)
  • exosome
  • cytokine

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Published Papers (3 papers)

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Research

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32 pages, 3557 KiB  
Article
Secretome Analysis of Human and Rat Pancreatic Islets Co-Cultured with Adipose-Derived Stromal Cells Reveals a Signature with Enhanced Regenerative Capacities
by Erika Pinheiro-Machado, Bart J. de Haan, Marten A. Engelse and Alexandra M. Smink
Cells 2025, 14(4), 302; https://doi.org/10.3390/cells14040302 - 18 Feb 2025
Viewed by 828
Abstract
Pancreatic islet transplantation (PIT) is a promising treatment for type 1 diabetes (T1D) but faces challenges pre- and post-transplantation. Co-transplantation with mesenchymal stromal cells (MSCs), known for their regenerative properties, has shown potential in improving PIT outcomes. This study examined the secretome of [...] Read more.
Pancreatic islet transplantation (PIT) is a promising treatment for type 1 diabetes (T1D) but faces challenges pre- and post-transplantation. Co-transplantation with mesenchymal stromal cells (MSCs), known for their regenerative properties, has shown potential in improving PIT outcomes. This study examined the secretome of islets cultured alone compared to the secretomes of islets co-cultured with adipose-derived stromal cells (ASCs), a subtype of MSCs, under transplantation-relevant stressors: normoxia, cytokines, high glucose, hypoxia, and combined hypoxia and high glucose. Islet co-culture with ASCs significantly altered the proteome, affecting pathways related to energy metabolism, angiogenesis, extracellular matrix organization, and immune modulation. Key signaling molecules (e.g., VEGF, PDGF, bFGF, Collagen I alpha 1, IL-1α, and IL-10) were differentially regulated depending on culture conditions and ASC presence. Functional assays demonstrated that the co-culture secretome could enhance angiogenesis, collagen deposition, and immune modulation, depending on the stress conditions. These findings highlight possible mechanisms through which ASCs may support islet survival and function, offering insights into overcoming PIT challenges. Moreover, this work contributes to identifying biomarkers of the post-transplantation microenvironment, advancing therapeutic strategies for T1D and regenerative medicine. Full article
(This article belongs to the Special Issue Adipose-Derived Stem Cells: Current Applications and Future Directions)
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17 pages, 3642 KiB  
Article
Mesenchymal Stem/Stromal Cells Reverse Adipose Tissue Inflammation in Pigs with Metabolic Syndrome and Renovascular Hypertension
by Alexander B. C. Krueger, Xiangyang Zhu, Sarosh Siddiqi, Emma C. Whitehead, Hui Tang, Kyra L. Jordan, Amir Lerman and Lilach O. Lerman
Cells 2025, 14(1), 40; https://doi.org/10.3390/cells14010040 - 2 Jan 2025
Cited by 1 | Viewed by 1017
Abstract
Metabolic syndrome (MetS) is associated with low-grade inflammation, which can be exacerbated by renal artery stenosis (RAS) and renovascular hypertension, potentially worsening outcomes through pro-inflammatory cytokines. This study investigated whether mesenchymal stem/stromal cells (MSCs) could reduce fat inflammation in pigs with MetS and [...] Read more.
Metabolic syndrome (MetS) is associated with low-grade inflammation, which can be exacerbated by renal artery stenosis (RAS) and renovascular hypertension, potentially worsening outcomes through pro-inflammatory cytokines. This study investigated whether mesenchymal stem/stromal cells (MSCs) could reduce fat inflammation in pigs with MetS and RAS. Twenty-four pigs were divided into Lean (control), MetS, MetS + RAS, and MetS + RAS + MSCs. In the MSC-treated group, autologous adipose-derived MSCs (107 cells) were injected into the renal artery six weeks after RAS induction. After four weeks, fat volumes and inflammatory markers were assessed. MSC treatment reduced levels of pro-inflammatory cytokines (MCP-1, TNF-a, IL-6) in the renal vein blood and in perirenal fat. The MSCs also decreased fat fibrosis, restored adipocyte size, and altered adipogenesis-related gene expression, particularly in the perirenal fat. These effects were less pronounced in subcutaneous fat. The MSC therapy attenuated fat inflammation and improved metabolic outcomes in pigs with MetS + RAS, suggesting that adipose-derived MSCs may offer a promising therapeutic approach for metabolic disorders. Full article
(This article belongs to the Special Issue Adipose-Derived Stem Cells: Current Applications and Future Directions)
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Review

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22 pages, 12007 KiB  
Review
Therapeutic Potential of Adipose-Derived Regenerative Cells for Ischemic Diseases
by Yiyang Che, Yuuki Shimizu and Toyoaki Murohara
Cells 2025, 14(5), 343; https://doi.org/10.3390/cells14050343 - 27 Feb 2025
Viewed by 542
Abstract
Adipose-derived regenerative cells (ADRCs) are one of the most promising cell sources that possess significant therapeutic effects. They have now become a main source of cell therapy for the treatment of ischemic diseases due to their easy accessibility, expansion, and differentiation. Additionally, ADRCs [...] Read more.
Adipose-derived regenerative cells (ADRCs) are one of the most promising cell sources that possess significant therapeutic effects. They have now become a main source of cell therapy for the treatment of ischemic diseases due to their easy accessibility, expansion, and differentiation. Additionally, ADRCs can release multiple paracrine factors and extracellular vesicles that contribute to tissue regeneration by promoting angiogenesis, regulating inflammation, alleviating apoptosis, and inhibiting fibrosis. However, ADRCs still have some limitations to realize their full therapeutic potential. To address these issues, protective mechanistic studies and bioengineering studies have been carried out. This review focused on the recently studied mechanisms, such as paracrine factors, cell fusion, and mitochondrial transfer, involving the therapeutic potential of ADRCs in ischemic diseases and discussed some modification techniques of ADRCs. Full article
(This article belongs to the Special Issue Adipose-Derived Stem Cells: Current Applications and Future Directions)
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