Study on Human Mesenchymal Stem Cells—2nd Edition
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 347
Special Issue Editor
Interests: heart failure; ischemic cardiomyopathy; cardiac regeneration and repair
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal stem cells (MSCs) are a group of multipotent cells of mesodermal origin. They were originally obtained from bone marrow, although MSC-like cells were subsequently derived from other tissues, including the placenta, umbilical cord, adipose tissue, skeletal muscle, and corneal stroma. Despite being used in hundreds of clinical trials, their retrospective derivation in culture poses challenges in understanding their anatomical identity, phenotype, tissue localization, and biological functions. Although differentiation in specific lineages can avail the stem cell characteristics of MSCs contributing to tissue regeneration, MSCs via paracrine and juxtracrine mechanisms mediated by immunomodulatory and growth factors pinpoint crucial reparative mechanisms.
The therapeutic value of MSCs is being explored in a variety of diseases, including immunological inflammatory and degenerative diseases as well as cancer. Despite some setbacks, MSCs have emerged as one of the most promising sources for cell-based cardiac regenerative and reparative therapy. At present, there is a need to discern the characteristics of tissue-specific MSCs and harmonize the methods and definitions for these cells. Likewise, novel approaches (genetic engineering and physical therapy) have been developed to enhance the use of MSCs in the treatment of various diseases.
This Special Issue will focus on different aspects of human mesenchymal stem cells, including molecular, gene, application, therapy, etc. We welcome original reviews, research articles, communications, and technical notes on human mesenchymal stem cells.
Dr. Michela Noseda
Guest Editor
Manuscript Submission Information
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Keywords
- mesenchymal stem cells
- disease
- cardiac
- therapy
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Related Special Issue
- Study on Human Mesenchymal Stem Cells in Cells (5 articles)
