Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 August 2025 | Viewed by 86
Special Issue Editor
2. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA
Interests: neurodegenerative disease; ALS; neuroinflammation; autophagy, motor neurons; microglia
Special Issue Information
Dear Colleagues,
Autophagy plays a pivotal role in maintaining cellular homeostasis by degrading and recycling damaged organelles and proteins. The dysregulation of autophagy is increasingly recognized as a critical factor in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). This Special Issue will explore the intricate relationship between autophagy and neurodegeneration, delving into cellular and molecular mechanisms, therapeutic potential, and disease progression. We welcome original research and review articles that provide insights into how autophagic pathways influence neuronal health and survival, with a focus on ALS and other neurodegenerative conditions. By bridging the gap between basic research and translational applications, this Special Issue will advance our understanding of the role of autophagy in neurodegeneration and foster innovative therapeutic strategies.
Dr. Valeria Gerbino
Guest Editor
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Keywords
- autophagy
- neurodegeneration
- amyotrophic lateral sclerosis (ALS)
- protein aggregation
- cellular homeostasis
- lysosomal dysfunction
- neuronal health
- therapeutic targets
- molecular pathways
- neuroprotective strategies
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