Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell and Molecular Mechanisms of Cytogenesis submission deadline 25 Aug 2026 | 1 articles | Viewed by 9826 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives
edited by Peter Van Endert
submission deadline 25 Aug 2026 | 2 articles | Viewed by 4582 | Submission Open
Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy
Molecular Mechanisms of Trophoblast Differentiation
edited by Milica Jovanović Krivokuća and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 1879 | Submission Open
Keywords: trophoblast differentiation; cytotrophoblast; syncytiotrophoblast; extravillous trophoblast; trophoblast stem cells; molecular mechanisms; signaling pathways; epigenetic regulation
Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms
edited by Masmoudi-Kouki Olfa and
submission deadline 25 Aug 2026 | 1 articles | Viewed by 1217 | Submission Open
Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling
(This special issue belongs to the Section Stem Cells)
Molecular Mechanisms and Novel Therapeutics for Glioblastoma
edited by Hirotaka Ito and
submission deadline 25 Aug 2026 | 2 articles | Viewed by 1209 | Submission Open
Keywords: glioblastoma; molecular mechanisms; oncolytic virus therapy; immunotherapy; tumor microenvironment; translational research; neurosurgery
(This special issue belongs to the Section Cellular Neuroscience)
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 25 Aug 2026 | Viewed by 473 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Critical Topics in Plant, Algae and Fungi Cell Biology
edited by
submission deadline 25 Aug 2026 | Viewed by 360 | Submission Open
Keywords: cells; molecules; signaling; functions; development; methods; technologies
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by and Olufunto Badmus
submission deadline 25 Aug 2026 | 1 articles | Viewed by 262 | Submission Open
Keywords: NAFLD; MASLD; hepatic steatosis; obesity; insulin resistance; fibrosis; cirrhosis
(This special issue belongs to the Section Cellular Pathology)
From Protection to Pathology: Beneficial and Deleterious Roles of Extracellular Vesicle Cargo
edited by
submission deadline 25 Aug 2026 | Viewed by 245 | Submission Open
Keywords: extracellular vesicle cargo profiling; exosome cargo heterogeneity; EV cargo modulation; small EV bioengineering; therapeutic cargo loading; engineered exosomes; targeted EV delivery
(This special issue belongs to the Section Intracellular and Plasma Membranes)
New Trends and Advances in Induced Neural Cells and iPSC Technologies
edited by
submission deadline 28 Aug 2026 | 1 articles | Viewed by 2372 | Submission Open
Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling
(This special issue belongs to the Section Cellular Neuroscience)
Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies
edited by
submission deadline 30 Aug 2026 | 5 articles | Viewed by 9856 | Submission Open
Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies
(This special issue belongs to the Section Cellular Immunology)
Signal Transduction and Targeted Therapy for Tumors submission deadline 30 Aug 2026 | 6 articles | Viewed by 9702 | Submission Open
Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy
(This special issue belongs to the Section Cell Signaling)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Aug 2026 | 4 articles | Viewed by 8387 | Submission Open
Keywords: Alzheimer’s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses
edited by
submission deadline 30 Aug 2026 | 5 articles | Viewed by 4804 | Submission Open
Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies
Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting
edited by
submission deadline 30 Aug 2026 | 1 articles | Viewed by 3036 | Submission Open
Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Aug 2026 | 1 articles | Viewed by 2793 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Cellular Responses During Wound and Regeneration submission deadline 30 Aug 2026 | 3 articles | Viewed by 2602 | Submission Open
Keywords: inflammation; wound and regeneration; clotting; reduction–oxidation reactions; fibroblasts; proliferation; endothelial; extracellular matrix
(This special issue belongs to the Section Stem Cells)
The Lipid Metabolism and Signaling in Dry Eye Disease
edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak
submission deadline 30 Aug 2026 | Viewed by 456 | Submission Open
Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms
Epigenetic Plasticity: How Chromatin Dynamics Orchestrate Fundamental Life Processes
edited by and Subhash Chandra Sethi
submission deadline 30 Aug 2026 | Viewed by 287 | Submission Open
Keywords: chromatin organization; chromatin remodelers; epigenetic modifications; epigenetic modifiers; chromosome segregation; transcription; DNA replication; DNA damage and repair; cancer; aging
(This special issue belongs to the Section Cell and Gene Therapy)
Molecular and Cellular Mechanisms and Novel Therapies of Ocular Disease
edited by Valery I. Shestopalov
submission deadline 30 Aug 2026 | Viewed by 202 | Submission Open
Keywords: ocular disease; neuroprotection; regeneration
(This special issue belongs to the Section Cellular Pathology)
New Advances in Targeted Therapy for Solid Tumor
edited by Jung Eun Park
submission deadline 30 Aug 2026 | Viewed by 188 | Submission Open
Keywords: CAR-X cells; antibody–drug conjugates (ADCs); bispecific/multi-specific antibodies; PROTACs; tumor microenvironment (TME); immune checkpoint blockade; metabolic reprogramming; patient-derived organoids (PDOs); 3D bioprinting
(This special issue belongs to the Section Cellular Pathology)
The Role of Cilia in Health and Diseases—2nd Edition
edited by Rim Hjeij
submission deadline 31 Aug 2026 | 6 articles | Viewed by 16501 | Submission Open
Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Aug 2026 | 6 articles | Viewed by 14947 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 6570 | Submission Open
Keywords: Alpha-, Beta-, and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Gut Microbiota, Metabolites, and Immune Regulation in Gastrointestinal Diseases
edited by and Subir Kumar Juin
submission deadline 31 Aug 2026 | 3 articles | Viewed by 5593 | Submission Open
Keywords: gut microbiota; microbial metabolites; inflammation; immunology; gut-barrier; gastrointestinal disease
Molecular Mechanisms Underlying Inflammatory Pain
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 5060 | Submission Open
Keywords: molecular mechanisms; inflammatory pain; nociception; neuronal sensitization; neuroimmune interactions
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Aug 2026 | 2 articles | Viewed by 5007 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology
edited by
submission deadline 31 Aug 2026 | 4 articles | Viewed by 4449 | Submission Open
Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms
(This special issue belongs to the Section Tissues and Organs)
Inflammation and Aging in Acute and Chronic Kidney Injury submission deadline 31 Aug 2026 | 2 articles | Viewed by 2996 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; inflammation; aging
(This special issue belongs to the Section Cellular Aging)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2544 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor–immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
New Molecular Insights into Hepatitis and Hepatic Cancer
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2417 | Submission Open
Keywords: hepatitis; alcoholic and non-alcoholic steatohepatitis; HBV and HCV; hepatic Cancer; hepatocellular carcinoma; chronic liver disease; cellular and molecular basis; signaling pathways; antiviral therapies; immunotherapy; therapeutic advances
(This special issue belongs to the Section Cellular Pathology)
Gene and Cell Therapy in Regenerative Medicine—Third Edition submission deadline 31 Aug 2026 | 2 articles | Viewed by 1902 | Submission Open
Keywords: gene therapy; cell therapy; regenerative medicine; growth factors; stem cells
(This special issue belongs to the Section Cell and Gene Therapy)
Advances in CAR Cell Therapies and Manufacturing
edited by William J. Kelly and Madhuresh C. Sumit
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1892 | Submission Open
Keywords: CAR cells; autologous; allogeneic; crispr; lentivirus; expansion; cryopreservation; isolation; biomarker; cytokines
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1833 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Lipoprotein and Cardiovascular Diseases Therapy
edited by Verity Ramirez and Wenliang Song
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1742 | Submission Open
Keywords: lipoprotein; cholesterol; cardiovascular disease; lipid-lowering therapy
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanisms and Biomarkers of Neurotoxicity: From Molecular Pathways to Therapeutic Interventions
edited by Nyzil Massey, Shreesh Raj Sammi and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1518 | Submission Open
Keywords: neurotoxicity mechanisms; neuroinflammation; oxidative stress; biomarkers; neuroimaging; electrophysiology; glial activation; neurodegeneration; translational therapeutics; environmental neurotoxicology
(This special issue belongs to the Section Cellular Neuroscience)
Resolving Chronic Inflammation: Molecular Mechanisms, Cellular Signaling and Therapeutic Frontiers submission deadline 31 Aug 2026 | 2 articles | Viewed by 1512 | Submission Open
Keywords: inflammatory mediators; cells polarization; apoptosis; epigenetic regulation; resolution pharmacology[EE2.1]; therapeutics
From Inflammaging to Dementia: Cellular and Molecular Drivers of Cognitive Decline
edited by Michael P. McDonald and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1195 | Submission Open
Keywords: neuroimmune crosstalk; brain-immune signaling; neuroinflammation; microglial activation; astrocytic reactivity; complement-mediated synaptic loss; cytokine modulation of synaptic plasticity; inflammasome signaling; blood–brain barrier dysfunction; neurovascular inflammation; immune-cell trafficking; synaptic dysfunction; biomarkers; DNA damage and repair; interferons responses; immune-targeted therapeutics; cognitive decline
(This special issue belongs to the Section Cellular Neuroscience)
Gastrointestinal Cancers: Research, Novel Diagnostic and Treatment Methods
edited by and Michele Ghidini
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1032 | Submission Open
Keywords: gastrointestinal cancer; diagnostic; treatment options
(This special issue belongs to the Section Cellular Pathology)
Cellular Stress Responses in Early Embryonic and Stem Cell Development
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 990 | Submission Open
Keywords: early embryonic development; cellular stress responses; pluripotent stem cells; trophoblast biology; assisted reproductive technology (ART)
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Mechanisms of Ischemic Stroke
edited by Milani Deb-Chatterji
submission deadline 31 Aug 2026 | 2 articles | Viewed by 963 | Submission Open
Keywords: ischemic stroke; neuroinflammation; blood–brain barrier; neurovascular unit; molecular targets for stroke therapy
Cellular and Molecular Determinants of Inflammation: Immune Cell Function, Immunometabolism and Therapeutic Targeting
edited by Zenith Khashim and Quinn P. Peterson
submission deadline 31 Aug 2026 | 1 articles | Viewed by 819 | Submission Open
Keywords: inflammation; immune regulation; immunometabolism; immune cell function; organelle signaling; mitochondrial dynamics; extracellular vesicles; intercellular communication; tissue microenvironment; immune tolerance
(This special issue belongs to the Section Cellular Immunology)
Cellular Immunology at the Maternal–Fetal Interface
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 613 | Submission Open
Keywords: leukocytes at MFI; cytotoxicity at MFI; trophoblast recognition via the KIR-HLA axis; decidualization and senescence of endometrial stromal cells; trophoblast invasion; spiral artery remodeling; tolerogenic molecules; exosomes in maternal–fetal communication; endometrial receptivity
(This special issue belongs to the Section Reproductive Cells and Development)
New Trends and Advances in Molecular Targeted Therapy for Cancers
edited by Dhivya Sridaran and
submission deadline 31 Aug 2026 | Viewed by 590 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody–drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
Comprehensive Advances in Eye Diseases: Cellular and Molecular Mechanisms, Pathophysiology and Translational Perspectives in Ophthalmic Research
edited by and Kai-Yang Chen
submission deadline 31 Aug 2026 | 1 articles | Viewed by 571 | Submission Open
Keywords: ophthalmic diseases; cellular mechanisms; molecular pathways; retinal degeneration; glial cells; neurovascular unit; oxidative stress; inflammation; translational research; therapeutic innovation
(This special issue belongs to the Section Cell Signaling)
New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Aug 2026 | Viewed by 419 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities
edited by
submission deadline 31 Aug 2026 | Viewed by 398 | Submission Open
Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 31 Aug 2026 | Viewed by 335 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
Sickle Cell Disease: Current Advances in Molecular Mechanisms and Therapeutic Strategies
edited by and Paula Faustino
submission deadline 31 Aug 2026 | Viewed by 309 | Submission Open
Keywords: sickle cell disease; genetic modifiers; gene editing; SCD pathophysiology; SCD biomarkers; SCD treatment; SCD management
(This special issue belongs to the Section Cellular Pathology)
Recent Discoveries and Progress in Central Nervous System Neuroinflammation
edited by
submission deadline 31 Aug 2026 | Viewed by 300 | Submission Open
Keywords: autoimmune; cerebrovascular; diagnosis; immune cells; microglia; neoplastic; neurodegenerative; neuroinflammation; system interaction; therapeutic targets
(This special issue belongs to the Section Cellular Neuroscience)
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