Comprehensive Advances in Eye Diseases: Cellular and Molecular Mechanisms, Pathophysiology and Translational Perspectives in Ophthalmic Research
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 118
Special Issue Editors
2. Department of Ophthalmology, Cardinal Tien Hospital, New Taipei City 23148, Taiwan
Interests: oxidative stress; inflammation; autophagy; mitochondrial dynamics; endoplasmic reticulum stress; calcium channels; cell migration; retinal cell death modalities; retinal degeneration
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ophthalmic diseases represent a major global health burden and are increasingly recognized as complex, multifactorial conditions driven by intricate cellular and molecular mechanisms. Recent advances in cell biology, molecular signaling, and translational medicine have significantly enhanced our understanding of the pathophysiology underlying a wide spectrum of ocular disorders, including retinal degeneration, glaucoma, corneal disease, and ocular inflammation. These conditions are characterized by dynamic interactions among multiple cell types—such as neurons, glial cells, vascular endothelial cells, and immune cells—within the highly specialized microenvironment of the eye.
This Special Issue aims to provide a comprehensive platform for cutting-edge research that elucidates the cellular and molecular foundations of ophthalmic diseases, with particular emphasis on mechanisms such as oxidative stress, mitochondrial dysfunction, neurovascular unit disruption, inflammatory signaling, metabolic dysregulation, and extracellular matrix remodeling. In addition, we seek to highlight translational advances that bridge fundamental biological insights and clinical applications, including novel biomarkers, imaging technologies, pharmacological interventions, and emerging therapeutic strategies such as gene- and cell-based therapies.
By integrating basic, translational, and clinical research, this Special Issue aims to foster a deeper mechanistic understanding of ocular disease processes and to accelerate the development of innovative diagnostic and therapeutic approaches in ophthalmology.
Dr. Chi-Ming Chan
Dr. Kai-Yang Chen
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- ophthalmic diseases
- cellular mechanisms
- molecular pathways
- retinal degeneration
- glial cells
- neurovascular unit
- oxidative stress
- inflammation
- translational research
- therapeutic innovation
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