Cellular and Molecular Determinants of Inflammation: Immune Cell Function, Immunometabolism, and Therapeutic Targeting

Dear Colleagues,

Inflammation is a fundamental biological process underlying the pathogenesis of numerous acute and chronic diseases; however, its regulation is governed by complex and interconnected cellular and molecular mechanisms that remain incompletely understood. Recent advances demonstrate that inflammatory responses are orchestrated through the coordinated actions of immune cells and non-immune cells, involving canonical immune signaling pathways, cell-intrinsic metabolic programs, organelle dynamics, and intercellular communication within tissue microenvironments. This Special Issue aims to provide a focused platform for studies offering mechanistic and functional insights into how immune cell function, immunometabolism, and cell-type-specific signaling pathways regulate inflammatory initiation, amplification, and resolution. Emphasis will be placed on mitochondrial and organelle-associated signaling, extracellular vesicle-mediated communication, and immune parenchymal cell crosstalk, including inflammatory processes relevant to transplantation, tissue injury, and immune tolerance, as well as metabolic tissues such as pancreatic β cells and stem cell-derived cellular models. We welcome original research articles and authoritative reviews that move beyond descriptive observations and establish causal relationships in inflammatory regulation. Contributions addressing inflammation in metabolic, autoimmune, cardiovascular, neuroinflammatory, and transplantation-associated diseases, as well as studies exploring therapeutic strategies to modulate immune-mediated inflammation, are especially encouraged.

Dr. Zenith Khashim
Dr. Quinn P. Peterson
Guest Editors

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