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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Inflammasomes in Neurological Disorders

edited by

Juan Pablo de Rivero Vaccari

submission deadline 1 Nov 2026 | Viewed by 284 | Submission Open

Keywords: inflammasome; pyroptosis; caspase-1; ASC specks; IL-1beta; PANoptosis; CNS injury; neurodegenerative diseases; biomarkers; Alzheimer’s disease; Parkinson’s disease; multiple sclerosis; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cellular Neuroscience)

Plasticity of Skeletal, Cardiac and Smooth Muscles in COPD: Repair and Remodeling

edited by

Joaquim Gea Guiral

submission deadline 5 Nov 2026 | 3 articles | Viewed by 7027 | Submission Open

Keywords: injury; repair; adaptation; aerobic metabolism; muscle mass; limb muscles; respiratory muscles; proteolysis

Cancer Stem Cells in Triple-Negative Breast Cancer

edited by

Antonella Zannetti

and

Maria Grazia Caprio

submission deadline 5 Nov 2026 | Viewed by 457 | Submission Open

Keywords: cancer stem cells; TNBC; signal pathways; epithelial–mesenchymal transition; tumor microenvironment; targeted therapy; biomarkers

Advancements in Research on hiPSC-Derived Cells

edited by Akhilesh Kumar

submission deadline 10 Nov 2026 | 3 articles | Viewed by 8771 | Submission Open

Keywords: hiPSCs; hematopoietic progenitors; T cells; NK cells; cardiac cells; B cells; macrophages; neutrophiles; CRISPR/Cas9 technology; genetic engineering

(This special issue belongs to the Section Stem Cells)

Hematologic Diseases: From Cellular and Molecular Mechanisms to Therapies

edited by

Wei Du

and

Pier Paolo Piccaluga

submission deadline 10 Nov 2026 | 2 articles | Viewed by 3980 | Submission Open

Keywords: hematologic diseases; mechanisms; therapies

Cellular Senescence and Transformation: Unraveling the Biological Links Between Aging and Cancer

edited by

Yongye Huang

, Lin Yuan and Yang Yu

submission deadline 10 Nov 2026 | 3 articles | Viewed by 2279 | Submission Open

Keywords: aging; cancer; stem cells; gene editing; oncogene; apoptosis; targeted therapy; epigenetics

Molecular and Cellular Mechanisms of Heart Regeneration

edited by Mira Pronobis and

Dinender K. Singla

submission deadline 10 Nov 2026 | 1 articles | Viewed by 888 | Submission Open

Keywords: cardiac regeneration; cardiomyocyte proliferation; tissue remodeling; cardiovascular repair; regenerative therapy; cellular plasticity; myocardial infarction; heart failure

(This special issue belongs to the Section Cells of the Cardiovascular System)

Methane Biosynthesis

edited by

Divya Prakash

, James Ferry and

Shikha Singh Chauhan

submission deadline 10 Nov 2026 | Viewed by 436 | Submission Open

Keywords: methane; methanogenesis; methanogens; carbon cycle; gut microbiota; energy conservation; human diseases

New Insights into Platelet Physiology and Dysfunction

edited by Serena Valsami and

Sotiris Fortis

submission deadline 10 Nov 2026 | Viewed by 162 | Submission Open

Keywords: platelets; platelet function; platelet physiology; platelet dysfunction; platelet disorders; platelet biology; pathophysiology; platelet transfusion; hereditary platelet disorders; acquired platelet disorders

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 15 Nov 2026 | 5 articles | Viewed by 17560 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Nov 2026 | 7 articles | Viewed by 9784 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Nov 2026 | 4 articles | Viewed by 5737 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Mechanisms and Therapies in Chronic Pain

edited by Nikesh Kunder and June Bryan I. de la Peña

submission deadline 15 Nov 2026 | 1 articles | Viewed by 2550 | Submission Open

Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management

(This special issue belongs to the Section Cellular Pathology)

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 15 Nov 2026 | 1 articles | Viewed by 1172 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Cancer and Vessels: Insights at the Cellular and Molecular Levels

edited by Francesco Pezzella and Tom Donnem

submission deadline 15 Nov 2026 | 1 articles | Viewed by 638 | Submission Open

Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis

(This special issue belongs to the Section Cellular Pathology)

Metabolic Regulation of Cell Behavior and Implications for Aging

edited by

Eloy Bejarano

and José Antonio Rodríguez Navarro

submission deadline 15 Nov 2026 | Viewed by 421 | Submission Open

Keywords: metabolism; cellular aging; senescence; proteostasis; oxidative stress; glycation; autophagy

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Nov 2026 | Viewed by 352 | Submission Open

Keywords: traumatic brain injury; stroke; blood–brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

New Mechanistic Insights and Novel Therapeutic Options for Pulmonary Vascular Disease (PVD)

edited by

Yong-Xiao Wang

submission deadline 15 Nov 2026 | Viewed by 240 | Submission Open

Keywords: pulmonary vascular disease; pulmonary hypertension; pulmonary arterial hypertension; vascular contraction; vascular remodeling

Cellular Mechanisms and Molecular Signaling in Heart Failure

edited by Przemyslaw Leszek

submission deadline 15 Nov 2026 | Viewed by 126 | Submission Open

Keywords: heart failure; cellular mechanisms and molecular signaling; new directions in cellular mechanisms promising for novel heart failure therapies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Post-Transcriptional Control of Stem Cell Fate and Neural Development

edited by

Kun Tan

submission deadline 16 Nov 2026 | 1 articles | Viewed by 1847 | Submission Open

Keywords: post-transcriptional regulation; stem cell biology; neural development; developmental biology

(This special issue belongs to the Section Stem Cells)

Placenta in Tissue Engineering and Regeneration

edited by

Gayathri Rajaraman

submission deadline 16 Nov 2026 | Viewed by 541 | Submission Open

Keywords: placenta; stem cells; tissue engineering; clinical application; organ repair; regenerative medicine; biomaterials; clinical practice; bio-scaffolds; tissue regeneration

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 16 Nov 2026 | Viewed by 339 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β-cells

(This special issue belongs to the Section Cell Signaling)

Kidney Development: Cellular and Molecular Insights

edited by

Renfang Song Taylor

submission deadline 18 Nov 2026 | 1 articles | Viewed by 1508 | Submission Open

Keywords: kidney development; nephrogenesis; single-cell RNA-seq/ATAC-seq; congenital anomalies of the kidney and urinary tract (CAKUT); blood pressure regulation

Neurodevelopmental Factors of Autism Spectrum Disorder: Etiology to Therapy

edited by

George Ayoub

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1305 | Submission Open

Keywords: autism spectrum disorder; developmental factors; genetic contributions; environmental influences; gene–environment interactions; developing therapies

Molecular Mechanisms and Treatment Strategies in Metabolic Syndromes and Neurological Disorders

edited by

Shaohua Qi

and

George Augustine

submission deadline 20 Nov 2026 | Viewed by 464 | Submission Open

Keywords: neurological disorders; metabolic syndromes; neurodegenerative disease; systems biology; precision medicine; target therapy

(This special issue belongs to the Section Cellular Neuroscience)

Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression

edited by

Katerina Gioti

and

Apostolos Beloukas

submission deadline 20 Nov 2026 | Viewed by 359 | Submission Open

Keywords: cancer progression; cell death; senescence; cancer therapy

Cellular and Molecular Mechanisms of Microglia/Macrophages in the Nervous System

edited by Emanuela Paldino

submission deadline 20 Nov 2026 | Viewed by 355 | Submission Open

Keywords: microglia; macrophages; neurological disorders

Cellular and Molecular Basis of Sjögren’s Syndrome

edited by Muhammad Shahnawaz Soyfoo

submission deadline 20 Nov 2026 | Viewed by 305 | Submission Open

Keywords: Sjögren disease; epithelial dysfunction; immune tolerance; autoimmunity

Spotlight on Cell Biology Science: Selected Contributions from Editorial Board Members and Invited Experts

edited by

Alexander E. Kalyuzhny

submission deadline 20 Nov 2026 | Viewed by 106 | Submission Open

Keywords: cell structure; cell physiology; cellular metabolism; cellular immunology; intra- and extracellular signaling; cell movement and motility; autophagy; apoptosis; cell aging; cell senescence; cell techniques; cell growth and differentiation; stem cells; genetic disorders and therapy; omics; plant, algae and fungi cell biology; neurodegeneration; neuroinflammation

Fibrosis in Chronic Inflammatory Diseases

edited by

Mirko Manetti

Irene Rosa

and

Eloisa Romano

submission deadline 25 Nov 2026 | 9 articles | Viewed by 25239 | Submission Open

Keywords: fibrosis; fibroblasts; myofibroblasts; inflammation; molecular pathways; pathogenetic mechanisms; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in the Study of Tau Protein

edited by

Santosh Jadhav

submission deadline 25 Nov 2026 | 2 articles | Viewed by 11111 | Submission Open

Keywords: tau protein; post-translational modification; tauopathy filaments; neuro-immune interactions

(This special issue belongs to the Section Cellular Neuroscience)

Cellular Differentiation in Health and Disease

edited by Christine K. C. Loo and

Grant A. Ramm

submission deadline 25 Nov 2026 | 1 articles | Viewed by 3870 | Submission Open

Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation

(This special issue belongs to the Section Cell Microenvironment)

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 25 Nov 2026 | Viewed by 485 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Genetic Mechanisms and Pathological Links in Neurodevelopmental Disorders

edited by Luigi Balasco and

Cinzia Severini

submission deadline 25 Nov 2026 | Viewed by 222 | Submission Open

Keywords: neurodevelopmental disorders; genetics; pathogenic mechanisms; genetic animal models; gene–environment interactions; rare variants; common variants; developmental neurobiology; molecular mechanisms; genotype–phenotype relationships

(This special issue belongs to the Section Cellular Neuroscience)

New Advances in Anticancer Therapy

edited by

Dooil Jeoung

submission deadline 30 Nov 2026 | 5 articles | Viewed by 14502 | Submission Open

Keywords: antibody-based immunotherapy; cell therapy; personalized anticancer therapy; RNA vaccines; nanotechnology

(This special issue belongs to the Section Cellular Pathology)

Advances in Cardiomyocyte and Stem Cell Biology in Heart Disease

edited by

Ki Ho Park

submission deadline 30 Nov 2026 | 7 articles | Viewed by 11171 | Submission Open

Keywords: cardiomyocytes; stem cells; heart disease; regenerative medicine; ion channels; protein therapeutics; bioengineering; molecular biology

(This special issue belongs to the Section Cells of the Cardiovascular System)

Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy

edited by Behzad M. Toosi and

Andrew Freywald

submission deadline 30 Nov 2026 | 4 articles | Viewed by 7738 | Submission Open

Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor–stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology

(This special issue belongs to the Section Cell Microenvironment)

Molecular Insights into cAMP/PKA Pathway Regulation in Health and Disease

edited by

Elie Seaayfan

and

Martin Kömhoff

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3677 | Submission Open

Keywords: cAMP/PKA signaling; protein kinase A (PKA); cyclic AMP; EPAC; signal transduction; cellular homeostasis; metabolic regulation; disease mechanisms; molecular signaling; therapeutic targets; cross-talk in signaling pathways; protein–protein interactions; post-translational modifications; pharmacological interventions

Cellular and Molecular Basis of Brain Tumor

edited by

Wojciech Czyżewski

, Tomasz S. Mandat, Grzegorz Turek and Radosław Mlak

submission deadline 30 Nov 2026 | 2 articles | Viewed by 3173 | Submission Open

Keywords: brain tumor; glioma; tumor microenvironment; molecular oncology; epigenetics; tumor stem cells; biomarkers; therapeutic resistance; non-coding RNA; translational research

(This special issue belongs to the Section Cellular Pathology)

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2933 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Autoimmune Diseases: Immune Cells and Genetic and Epigenetic Regulations

edited by

Moncef M. Zouali

submission deadline 30 Nov 2026 | 4 articles | Viewed by 2815 | Submission Open

Keywords: autoimmune diseases; immune cells; lymphocytes; antigen-presenting cells; natural killer cells; innate lymphoid cells; epigenetic modifications; autoimmunity

(This special issue belongs to the Section Cellular Immunology)

Basic Mechanisms and Emerging Therapeutic Strategies for Spinal Cord Injury

edited by

Daniel J. Hellenbrand

and Angela R. Filous

submission deadline 30 Nov 2026 | 3 articles | Viewed by 2597 | Submission Open

Keywords: spinal cord injury; neuroinflammation; neural regeneration; axon growth; neurons; glial cells; oligodendrocytes; myelin; astrocytes; microglia

Novel Insights into Molecular and Cellular Mechanisms Underlying Chronic Pain

edited by

Mariacristina Mazzitelli

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2586 | Submission Open

Keywords: pain; pain management; sexual dimorphism; neurons; non-neuronal factors

(This special issue belongs to the Section Cellular Pathology)

Circadian Rhythms in Action: Cellular and Molecular Mechanisms Revealed by Model Organisms

edited by

Girish Chandra Melkani

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2380 | Submission Open

Keywords: circadian rhythm; molecular regulation; cellular mechanisms; model organisms; time-restricted feeding; metabolism; aging; neurodegeneration

Extracellular Vesicles in Disease Pathogenesis, Therapeutics and Biomarker Discovery

edited by

Susmita Sil

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2314 | Submission Open

Keywords: extracellular vesicles; exosomes; exomeres; apoptotic bodies; macrovesicles; EV-cargoes; EVs as biomarkers; EVs in therapy

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Sex Differences in Cardiovascular Structure and Function—from Mechanisms to Therapeutics

edited by

Roshanak Rahimian

and

Mitra Esfandiarei

submission deadline 30 Nov 2026 | 2 articles | Viewed by 2062 | Submission Open

Keywords: cardiovascular diseases; sex hormones; sex differences; vascular and cell signaling; therapeutic targets

LPS-Induced Inflammatory Diseases

edited by

Lin-Hua Jiang

and

Pankaj Kumar

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2047 | Submission Open

Keywords: lipopolysaccharide (LPS); endotoxemia; inflammation; LPS signaling; acute lung injury; inflammatory cytokines; therapeutic targets

(This special issue belongs to the Section Cellular Pathology)

Molecular and Cellular Mechanisms of Type 1 Diabetes (T1D)

edited by Robert Sharp and

Itamar Raz

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1984 | Submission Open

Keywords: T1D; autoimmunity; type 1 diabetes; single-nucleotide polymorphisms (SNPs); viral/bacterial pathogens; T-cell biology; inflammation; pancreatic beta cells; immunoregulatory; molecular biology; cellular biology

(This special issue belongs to the Section Cellular Pathology)

Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis

edited by Xu Jing

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1815 | Submission Open

Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers

(This special issue belongs to the Section Cellular Metabolism)

B Cells in Action: Interaction Dynamics and Functional Decisions

edited by Michael L. Atchison and

Sulagna Sanyal

submission deadline 30 Nov 2026 | 3 articles | Viewed by 1624 | Submission Open

Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response

(This special issue belongs to the Section Cellular Immunology)

Displaying special issue 401-450 on page 9 of 12.

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