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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 31 Dec 2025 | Viewed by 71 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Kinin System in Health and Disease: Cellular and Molecular Perspectives

edited by Marcos Gregnani and Leonardo Martins

submission deadline 31 Dec 2025 | Viewed by 70 | Submission Open

Keywords: kallikrein– kinin system; bradykinin receptors; inflammation; cardiovascular disease; molecular pathways

(This special issue belongs to the Section Cellular Pathology)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 31 Dec 2025 | Viewed by 69 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Inflammation and Aging in Acute and Chronic Kidney Injury

edited by

Massimiliano Migliori

Vincenzo Cantaluppi

and

Marita Marengo

submission deadline 31 Dec 2025 | Viewed by 54 | Submission Open

Keywords: chronic kidney disease; acute kidney injury; inflammation; aging

(This special issue belongs to the Section Cellular Aging)

Cellular and Molecular Mechanisms of Traumatic Injury and Resolution

edited by

Upendra K. Kar

and

Hamed Moheimani

submission deadline 31 Dec 2025 | Viewed by 54 | Submission Open

Keywords: traumatic injury-associated immunometabolism; trauma-induced coagulopathy; endothelial dysfunction; cell death pathways; extracellular vesicles; single-cell and spatial omics; multi-omics; damage-associated molecular patterns; biomarker discovery; precision therapeutics

(This special issue belongs to the Section Cellular Pathology)

Genomics and Cellular Mechanisms in Ovarian Cancer

edited by Hao Huang

submission deadline 31 Dec 2025 | Viewed by 51 | Submission Open

Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment

(This special issue belongs to the Section Tissues and Organs)

The Role of the Gene Expression and Regulation of the Pathogenesis of Oral Submucous Fibrosis

edited by

Sanjit Mukherjee

submission deadline 31 Dec 2025 | Viewed by 37 | Submission Open

Keywords: oral submucous fibrosis (OSMF); collagen deposition; epigenetic modifications; next-generation sequencing; oral cancer; progressive fibrosis

(This special issue belongs to the Section Cellular Pathology)

Extracellular Vesicles in Obesity and Metabolic Disease: Emerging Mechanisms, Inter-Organ Crosstalk and Translational Opportunities

edited by

Mangesh Hade

submission deadline 31 Dec 2025 | Viewed by 35 | Submission Open

Keywords: extracellular vesicles; exosomes; metabolic syndrome; obesity; insulin resistance; type 2 diabetes; cardiovascular disease; MAFLD; fatty liver; adipose tissue; microRNA; metabolic inflammation; inter-organ communication; biomarker; therapeutic EVs

(This special issue belongs to the Section Intracellular and Plasma Membranes)

Colorectal Cancer: Molecular Mechanisms and Treatment Progress

edited by

Maurizio Capuozzo

submission deadline 31 Dec 2025 | Viewed by 32 | Submission Open

Keywords: colorectal cancer (CRC); tumor microenvironment; genetic and epigenetic alterations; immune evasion; targeted therapy and personalized medicine

(This special issue belongs to the Section Tissues and Organs)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 31 Dec 2025 | Viewed by 23 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

Molecular and Genetic Pathogenesis of Hematological Disorders

edited by

Hong Chang

submission deadline 10 Jan 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: hematological disorders; molecular and genetic mechanisms; signal transduction pathways; microenvironment; gene editing technologies; targeted therapies; novel biomarkers; mechanisms of treatment resistance; innovative therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

New Insights into Therapeutic Targets for Cardiovascular Diseases

edited by

Tamer Elbayoumi

and

Molly (Mingyi) Yao

submission deadline 15 Jan 2026 | 3 articles | Viewed by 7100 | Submission Open

Keywords: cardiovascular disease prevention and treatment; ischemic cardiomyopathies; endothelium injury/damage; cardiac remuscularization and repair; cardiovascular/angiogenic targets and biomarkers; targeted delivery platforms/systems/formulations; precision nanomedicine; targeted nano-theranostic applications; localized and systemic administration; safety and efficacy

(This special issue belongs to the Section Cells of the Cardiovascular System)

Recent Progress on Fibrosis and Cardiac Dysfunction

edited by

Tabito Kino

and

Tomoaki Ishigami

submission deadline 15 Jan 2026 | Viewed by 339 | Submission Open

Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Targeting Breast Cancer: Mechanisms of Resistance and Innovative Therapeutic Strategies

edited by Stefania Belli,

Daniela Esposito

and

Roberto Bianco

submission deadline 15 Jan 2026 | Viewed by 72 | Submission Open

Keywords: breast cancer; targeted therapies; novel therapeutic targets; mechanisms of drug resistance; innovative therapeutic strategies; targeting tumor microenvironment; immunotherapy in breast cancer

(This special issue belongs to the Section Cell Microenvironment)

Organ Regeneration: Cells, Organoids and Organs

edited by Jia Huang

submission deadline 15 Jan 2026 | Viewed by 40 | Submission Open

Keywords: organ regeneration; stem cells; organoids; tissue engineering; 3D bioprinting; regenerative medicine; interspecies chimera; blastocyst complementation; vascularization; immune compatibility

(This special issue belongs to the Section Tissues and Organs)

New Insights into Gene Research and Therapy for Diabetes Mellitus

edited by

Ann Simpson

and

Najah Therese Nassif

submission deadline 15 Jan 2026 | Viewed by 30 | Submission Open

Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 15 Jan 2026 | Viewed by 24 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Oral Stem Cells in Regenerative Biology

edited by

Oriana Trubiani

submission deadline 15 Jan 2026 | Viewed by 20 | Submission Open

Keywords: stem cells; differentiation; regenerative medicine; angiogenesis; inflammation; secretome; oral tissue induced pluripotent stem cells

(This special issue belongs to the Section Stem Cells)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1077 | Submission Open

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Neurotoxicity and Neurodegenerative Diseases: The Potential of Regenerative Medicine

edited by Elisabetta Mormone, Paola Crociani and

Gianluigi Ubaldo Mazzoccoli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 821 | Submission Open

Keywords: inflammation; iPSCs; MSCs; neural stem cells niche; neurodegeneration; regenerative medicine; ROS; PRP

(This special issue belongs to the Section Cellular Aging)

Role of Cell Organelles in Normal Aging, Senescence, and Cancer

edited by

Michael Lisanti

and Christopher Albanese

submission deadline 20 Jan 2026 | Viewed by 423 | Submission Open

Keywords: aging; accumulated damage; ROS-induced damage; protein aggregation; senescence; cancer; senescence escape; cell organelles; mitochondria; lysosomes; SASP; inflammation; IL1-beta/IL-6/IL-8

(This special issue belongs to the Section Cellular Aging)

Study on Human Mesenchymal Stem Cells—2nd Edition

edited by

Michela Noseda

submission deadline 20 Jan 2026 | Viewed by 258 | Submission Open

Keywords: mesenchymal stem cells; disease; cardiac; therapy

(This special issue belongs to the Section Stem Cells)

Dental Pulp Stem Cells in Tissue Repair and Regeneration

edited by

Sarah Peters

Kyle Vining

, Cristiane Franc and Jacques Nör

submission deadline 20 Jan 2026 | Viewed by 63 | Submission Open

Keywords: dental pulp stem cells; regenerative endodontics; regenerative medicine; dental pulp; reparative dentinogenesis

(This special issue belongs to the Section Tissues and Organs)

Gliomas: Molecular Insights, Next-Generation Therapies, and Precision Targeting

edited by

Mehdi Sanati

submission deadline 20 Jan 2026 | Viewed by 36 | Submission Open

Keywords: gliomas; molecular targets; precision oncology; immunotherapy; gene editing; tumor microenvironment

The Evolving Landscape of Cell and Gene Therapy—Opportunities, Challenges and the Road Ahead

edited by

Rai Ajit K. Srivastava

submission deadline 20 Jan 2026 | Viewed by 33 | Submission Open

Keywords: cell therapy; gene therapy/gene editing; micro RNAs; rare diseases; metabolic disease; cancer; diabetes; proatherogenic lipoproteins; drug discovery; ASO

Cellular Origin of Glioma: From Triggers to Treatments

edited by Katherine Karakoula

submission deadline 20 Jan 2026 | Viewed by 29 | Submission Open

Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells

Molecular Basis of Gynecological Disorders and Associated Infertility

edited by

Ahmad Albaghdadi

and

Nihar R. Nayak

submission deadline 20 Jan 2026 | Viewed by 24 | Submission Open

Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies

(This special issue belongs to the Section Cellular Pathology)

Intestinal Stem Cells

edited by

Natalia Soshnikova

and

Arunkumar Jagadeesan

submission deadline 20 Jan 2026 | Viewed by 23 | Submission Open

Keywords: stem cells; self-renewal; enterocytes; intestinal organoid; villus; crypt

(This special issue belongs to the Section Stem Cells)

Targeting Hallmarks of Cancer

edited by

Carlos Pérez Plasencia

submission deadline 25 Jan 2026 | 2 articles | Viewed by 4036 | Submission Open

Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer

Induced Pluripotent Stem Cells (iPSCs): Molecular and Cellular Mechanisms

edited by Masmoudi-Kouki Olfa and

Gérard Lizard

submission deadline 25 Jan 2026 | Viewed by 47 | Submission Open

Keywords: iPSCs; gene regulation; epigenetic reprogramming; cellular signaling; disease modeling

(This special issue belongs to the Section Stem Cells)

Decoding the Tumor-Immune Intersection: Opportunities for Breakthroughs in Cancer Therapies

edited by

Qiwei Wang

submission deadline 25 Jan 2026 | Viewed by 43 | Submission Open

Keywords: immuno-oncology; tumor-immune interface; tumor microenvironment; cancer immunotherapy; targeted therapy; immunometabolism; oncometabolism; epigenetics; combination strategies

(This special issue belongs to the Section Cellular Immunology)

Plant Stress and Acclimation Responses During Global Warming

edited by

Stanisław Karpiński

submission deadline 25 Jan 2026 | Viewed by 41 | Submission Open

Keywords: acclimatory responses in plants; chloroplast retrograde and nuclear anterograde signaling; excess light and heat shock responses; global warming and regulation of gene expression; energy dissipation as heat and cell death regulation; photosynthesis; stomatal conductance and transpiration regulation during heat waves

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Targeting Immune Dysfunction in Aging and Age-Related Diseases

edited by

Anna Aiello

and

Anna Calabrò

submission deadline 25 Jan 2026 | Viewed by 28 | Submission Open

Keywords: immunosenescence; inflammaging; immune dysfunction; aging; age-related diseases (ARDs); immune– metabolic interactions; immunomodulators; immunoceuticals; senotherapeutics; lifestyle interventions

Metabolic Flexibility in Cancer: How Tumor Cells Adapt Their Metabolism to Growth and Spread

edited by Erica Pranzini

submission deadline 25 Jan 2026 | Viewed by 26 | Submission Open

Keywords: cancer metabolism; metabolic plasticity; tumor microenvironment; oncometabolites; targeting cancer metabolism

The Developments and Applications of Vibrational Spectroscopy in Cellular Research

edited by

Maria Lasalvia

submission deadline 25 Jan 2026 | Viewed by 19 | Submission Open

Keywords: vibrational spectroscopy; FT-IR spectroscopy; Raman spectroscopy; biomedical diagnostics; cancer research; Alzheimer’ s disease; neurodegeneration; tissue engineering; spectroscopic biomarkers; label-free imaging

(This special issue belongs to the Section Cell Methods)

Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches

edited by

Luigi Racioppi

submission deadline 25 Jan 2026 | Viewed by 13 | Submission Open

Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics

(This special issue belongs to the Section Stem Cells)

Mechanisms Underlying Cardiovascular Aging

edited by Soheil Saeedi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 1679 | Submission Open

Keywords: cardiovascular aging; cellular senescence; epigenetic clock; endothelial cells; perivascular adipose tissue (PVAT); premature aging; senolytics; rejuvenating strategies

(This special issue belongs to the Section Cells of the Cardiovascular System)

Tumor Immune Responsiveness in the Era of T Cell Immunotherapy

edited by

Xin Li

and

Wenjian Wang

submission deadline 30 Jan 2026 | Viewed by 75 | Submission Open

Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation

Ubiquitin Ligases in Health and Diseases

edited by Haitao Luan

submission deadline 30 Jan 2026 | Viewed by 15 | Submission Open

Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting

(This special issue belongs to the Section Cell Signaling)

Advanced Technology for Cellular Imaging

edited by Alessandro Grinzato,

Vittoria Raimondi

and

J. Bernard Heymann

submission deadline 31 Jan 2026 | 8 articles | Viewed by 16030 | Submission Open

Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases

edited by

Prathapan Ayyappan

submission deadline 31 Jan 2026 | 5 articles | Viewed by 12929 | Submission Open

Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods

(This special issue belongs to the Section Cells of the Cardiovascular System)

Imaging Methods in Cell Biology

edited by

Claudia Moscheni

and

Nicoletta Gagliano

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7243 | Submission Open

Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology

(This special issue belongs to the Section Cell Methods)

Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance

edited by

Xinyu Wang

Lei Zhu

and Yuancheng Li

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4478 | Submission Open

Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product

(This special issue belongs to the Section Cell Microenvironment)

Renewing Reasons to Believe in Gene Therapies for Epilepsy

edited by Casper Gøtzsche

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3805 | Submission Open

Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need

(This special issue belongs to the Section Cells of the Nervous System)

Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy

edited by

Javier S. Castresana

submission deadline 31 Jan 2026 | Viewed by 212 | Submission Open

Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy

(This special issue belongs to the Section Stem Cells)

Diagnostic and Therapeutic Application of Extracellular Vesicles (EV)

edited by

Maria Magdalena Barreca

and

Chiara Corrado

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications

Single-Molecule Tracking for Live Cells

edited by

Zeno Földes-Papp

submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open

Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory

New Advances in Tissue Engineering and Regeneration

edited by

Giorgia Borciani

and

Giorgia Montalbano

submission deadline 31 Jan 2026 | Viewed by 170 | Submission Open

Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research

(This special issue belongs to the Section Tissues and Organs)

Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond

edited by Valeria Gerbino

submission deadline 31 Jan 2026 | Viewed by 133 | Submission Open

Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies

(This special issue belongs to the Section Cells of the Nervous System)

Function of Stress Granules in Normal Cells and in Alzheimer’s Disease

edited by