Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
Molecular Research in Osteoporosis submission deadline 30 Nov 2025 | Viewed by 60 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
Microautophagy: The Least Known of the Autophagy Strategies
edited by
submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open
Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs
(This special issue belongs to the Section Autophagy)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Nov 2025 | Viewed by 54 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 44 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 30 Nov 2025 | Viewed by 37 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Exclusive Review Issue: Cellular and Nuclear Biomechanics in Cytoskeleton-Driven Migration and Invasion submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open
Keywords: cytoskeletal dynamics; nuclear mechanics; cell migration and invasion; cell division; cell motility and adhesion; mechanotransduction
(This special issue belongs to the Section Cell Motility and Adhesion)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 30 Nov 2025 | Viewed by 23 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Aging)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 30 Nov 2025 | Viewed by 21 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Nov 2025 | Viewed by 20 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Wound Repair
edited by
submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open
Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 30 Nov 2025 | Viewed by 12 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 30 Nov 2025 | Viewed by 10 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 1 Dec 2025 | Viewed by 131 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 1 Dec 2025 | Viewed by 10 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 5 Dec 2025 | 5 articles | Viewed by 11452 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 10 Dec 2025 | 2 articles | Viewed by 3065 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Therapeutic Mechanism of Nervous System Inflammation—Second Edition submission deadline 10 Dec 2025 | 1 articles | Viewed by 1151 | Submission Open
Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 355 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 15 Dec 2025 | 21 articles | Viewed by 59746 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cells of the Nervous System)
Focus on Machinery of Cell Death
edited by , Prashanta Kumar Panda and
submission deadline 15 Dec 2025 | 6 articles | Viewed by 13214 | Submission Open
Keywords: cell death; autophagy; apoptosis; necrosis; ferroptosis; metabolism; stem cell biology; infection; aging; development; Alzheimer’ s; neurodegeneration; therapy
(This special issue belongs to the Section Cellular Pathology)
Mitochondria and Metabolism in Cancer Stem Cells (CSCs)
edited by and Christopher Albanese
submission deadline 15 Dec 2025 | 2 articles | Viewed by 2449 | Submission Open
Keywords: cancer stem cells; circulating tumor cells; drug resistance; metabolism; mitochondria; OXPHSOS; mitochondrial DNA (mtDNA); glycolysis; cell cycle; DNA damage; other metabolic processes; oxidative stress; senescence; therapeutic approaches
(This special issue belongs to the Section Stem Cells)
Cell Therapies in Cancer Treatment
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1371 | Submission Open
Keywords: cellular therapies; cancer; immune
DNA Methylation in Human Health and Disease: From Molecular Mechanisms to Clinical Applications submission deadline 15 Dec 2025 | Viewed by 482 | Submission Open
Keywords: DNA methylation; epigenetics; diseases; biomarkers; functional analysis
(This special issue belongs to the Section Cellular Pathology)
Exclusive Review Papers in Parkinson's Research
edited by and Ronald F. Pfeiffer
submission deadline 15 Dec 2025 | Viewed by 202 | Submission Open
Keywords: Parkinson’ s disease; alpha-synuclein; substantia nigra; mitochondria; non-motor symptoms; dopamine; levodopa
(This special issue belongs to the Section Cellular Aging)
Mechanisms and Therapies in Chronic Pain
edited by Nikesh Kunder and June Bryan I. de la Peña
submission deadline 15 Dec 2025 | Viewed by 98 | Submission Open
Keywords: chronic pain; pain mechanisms; pain targets; opioid alternatives; neurobiology; pre-clinical; translational research; pathophysiology; pain management
(This special issue belongs to the Section Cellular Pathology)
Functions of Cilia
edited by
submission deadline 15 Dec 2025 | Viewed by 72 | Submission Open
Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes
Recent Advances in the Understanding of Neuropsychiatric Illnesses
edited by and
submission deadline 15 Dec 2025 | Viewed by 62 | Submission Open
Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging
Physics of Cancer: How Mechanobiology Drives Cancer Progression
edited by
submission deadline 15 Dec 2025 | Viewed by 60 | Submission Open
Keywords: migration and invasion of cancer cells; cytomechanics and adhesive properties; cellular mechanotransduction; mechanical signals; viscoelasticity and stiffness; physics of cancer
The Symphony of Nature—the Precision of Life’s Regulation
edited by Weiguang Wang and Baocheng Liu
submission deadline 15 Dec 2025 | Viewed by 44 | Submission Open
Keywords: protein structure and function; allosteric regulation; conformational switches; enzyme catalysis and modification; molecular machines; molecular regulation; protein folding and misfolding
(This special issue belongs to the Section Cell Methods)
Organ and Tissue Fibrosis: Molecular Signals and Cellular Mechanisms—Second Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 32 | Submission Open
Keywords: fibrosis; scarring; cytokine; myofibroblasts; extracellular matrix; growth factors; mesenchymal transition
(This special issue belongs to the Section Tissues and Organs)

The Role of Extracellular Vesicles in Kidney Disease

 

edited by and Ciro Tetta
submission deadline 15 Dec 2025 | Viewed by 29 | Submission Open
Keywords: extracellular vesicles (EVs); microRNAs (miRs); chronic kidney disease (CKD); acute kidney injury (AKI); regenerative medicine; biomarkers; artificial intelligence (AI); nephrology; urology; precision medicine
(This special issue belongs to the Section Cell Microenvironment)
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 15 Dec 2025 | Viewed by 26 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 15 Dec 2025 | Viewed by 17 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
Advanced Research in Neurogenesis and Neuroinflammation
edited by
submission deadline 15 Dec 2025 | Viewed by 17 | Submission Open
Keywords: neurogenesis; neuroinflammation; neurodegeneration; neurodegenerative diseases; cognitive functions
Molecular Mechanisms of Cognitive Function and Dysfunction submission deadline 20 Dec 2025 | 1 articles | Viewed by 2101 | Submission Open
Keywords: cognition; neurodevelopment; neurotransmission; molecular mecanisms; signaling; disorders; therapy
(This special issue belongs to the Section Cells of the Nervous System)
Microglial Functions in Neurodegenerative Diseases: In Search of Potential Therapeutic Targets
edited by and María Martín Estebané
submission deadline 20 Dec 2025 | Viewed by 226 | Submission Open
Keywords: microglia; inflammation; neural damage; mitochondria; potential targets
(This special issue belongs to the Section Cellular Aging)
State-of-the-Art Insights into the Cell Microenvironment
edited by
submission deadline 20 Dec 2025 | Viewed by 76 | Submission Open
Keywords: cell microenvironment; stem cells; organoid and 3D culture models
Evaluation of the Properties and Effectiveness of Nutritional Factors Using In Vitro Assays, Including Cell Cultures and Organoids
edited by and Sylwia Orczewska-Dudek
submission deadline 20 Dec 2025 | Viewed by 40 | Submission Open
Keywords: cell cultures; organoids; novel nutritional factors; extract; cells viability; cells proliferation; cells cytotoxicity; cell signaling; cells apoptosis; oxidative stress
Advances in Human Pluripotent Stem Cells submission deadline 20 Dec 2025 | Viewed by 18 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells  
(This special issue belongs to the Section Stem Cells)
Advanced Research on Genomic Instability and Gene Expression in Developmental Disorders
edited by
submission deadline 20 Dec 2025 | Viewed by 11 | Submission Open
Keywords: development; neurological disease; cancer; genetic; epigenetic
Targeting Thermogenesis in Metabolic Disorders: Novel Pharmacological and Lifestyle Interventions
edited by
submission deadline 20 Dec 2025 | Viewed by 5 | Submission Open
Keywords: thermogenesis modulation; metabolic disorders; obesity; adipose tissue biology; thermogenic mechanisms; mitochondrial function
Functional Genomics and Morphological Profiling in Saccharomyces cerevisiae
edited by and Hisao Moriya
submission deadline 24 Dec 2025 | Viewed by 18 | Submission Open
Keywords: functional genomics; morphological profiling; Saccharomyces cerevisiae; overexpression
Kidney Injury Biomarkers: From Early Detection to Transition to Chronic Kidney Disease submission deadline 25 Dec 2025 | 1 articles | Viewed by 1382 | Submission Open
Keywords: acute kidney injury; acute kidney disease; chronic kidney disease; circulating biomarkers; urinary biomarkers; multiple biomarker panel; diagnosis; prediction; management
(This special issue belongs to the Section Tissues and Organs)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 25 Dec 2025 | Viewed by 492 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
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