Molecular Mechanisms of Autophagy, Apoptosis and Senescence and Therapeutic Advances in Cancer Progression

Dear Colleagues,

Programmed cell death and cellular senescence play critical roles in cancer development and progression. When cell death pathways are disrupted, cancer cells gain the ability to escape elimination and secure survival advantages. Meanwhile, senescence serves as a powerful anti-tumor barrier by halting unchecked cell proliferation—yet malignant cells that learn to bypass this safeguard advance disease progression and resist treatment. The intricate balance and crosstalk among these processes not only illuminate tumor biology but also highlight promising avenues for novel therapeutic strategies.

With this Special Issue, we invite researchers to contribute original studies and insightful reviews that push the boundaries of our understanding. Topics of interest include the molecular underpinnings of apoptosis, autophagy, and senescence in tumor development; key regulatory factors and signaling networks; innovative in vitro and in vivo models; the influence of these pathways on therapy resistance and tumor–microenvironment interactions; and emerging strategies that harness or target these processes for more effective cancer treatments.

Dr. Katerina Gioti
Prof. Dr. Apostolos Beloukas
Guest Editors

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