Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 1146

Special Issue Editor


E-Mail Website
Guest Editor
1. Cellular Therapy Laboratory, CancerCare Manitoba, Winnipeg, MB R3A 1R9, Canada
2. HLA Lab, CancerCare Manitoba, Winnipeg, MB R3A 1R9, Canada
3. Department of Immunology, University of Manitoba, Winnipeg, MB R3E 3P4, Canada
4. Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 3P4, Canada
5. Manitoba Centre for Advanced Cell & Tissue Therapy, Winnipeg, MB R3A 1R9, Canada
Interests: autoimmune diseases; transplantation; immunotherapy; cytokines; novel cellular therapy; immune regulatory cells

Special Issue Information

Dear Colleagues,

We invite scientists to submit original research articles and literature reviews that seek to explore the development and efficacy of cell and gene therapies for the treatment of immune diseases. Potential topics include, but are not limited to, the following:

  • Development/application of novel cell and gene therapies for treating cancers, including CARs, TCR-T cells, TILs and others.
  • Development/application of novel gene therapies for genetic diseases.
  • Development/application of novel cell and gene therapies for autoimmune diseases, infection, cardiovascular disease and other disorders.
  • Gene vector design.
  • Exploration of delivery routes of genes or gene-editing reagents to the relevant target cells.

Dr. Qingdong Guan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell therapy
  • gene therapy
  • chimeric antigen receptor T cells
  • T cell receptor-engineered T cells
  • tumor-infiltrating lymphocytes
  • hematopoietic stem cells
  • chimeric antigen receptor NK cells
  • induced pluripotent stem cells
  • mesenchymal stem/stromal cells
  • immune regulatory cells

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 1736 KiB  
Review
Strategies to Overcome Antigen Heterogeneity in CAR-T Cell Therapy
by Bohan Zhang, Jiawen Wu, Hua Jiang and Min Zhou
Cells 2025, 14(5), 320; https://doi.org/10.3390/cells14050320 - 20 Feb 2025
Cited by 1 | Viewed by 859
Abstract
Chimeric antigen receptor (CAR) gene-modified T-cell therapy has achieved significant success in the treatment of hematological malignancies. However, this therapy has not yet made breakthroughs in the treatment of solid tumors and still faces issues of resistance and relapse in hematological cancers. A [...] Read more.
Chimeric antigen receptor (CAR) gene-modified T-cell therapy has achieved significant success in the treatment of hematological malignancies. However, this therapy has not yet made breakthroughs in the treatment of solid tumors and still faces issues of resistance and relapse in hematological cancers. A major reason for these problems is the antigenic heterogeneity of tumor tissues. This review outlines the antigenic heterogeneity encountered in CAR-T cell therapy and the corresponding strategies to address it. These strategies include using combination therapy to increase the abundance of target antigens, optimizing the structure of CARs to enhance sensitivity to low-density antigens, developing multi-targeted CAR-T cells, and reprogramming the TME to activate endogenous immunity. These approaches offer new directions for overcoming tumor antigenic heterogeneity in CAR-T cell therapy. Full article
Show Figures

Figure 1

Back to TopTop