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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response

edited by

Ioannis P. Trontzas

and

Konstantinos Syrigos

submission deadline 28 Apr 2026 | Viewed by 82 | Submission Open

Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Quality of Life and Management of Pediatric Cancer

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 30 Apr 2026 | 5 articles | Viewed by 8112 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Advancements in Molecular Research of Prostate Cancer

edited by

Anait S. Levenson

submission deadline 30 Apr 2026 | 6 articles | Viewed by 8018 | Submission Open

Keywords: prostate cancer; molecular targets; tumor heterogeneity; targeted interception and therapies; noninvasive biomarkers; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Immune Microenvironment and Immunotherapy in Malignant Brain Tumors

edited by Masaki Terabe and

Mark R. Gilbert

submission deadline 30 Apr 2026 | 4 articles | Viewed by 6084 | Submission Open

Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Human Microbiome, Diet and Cancerogenesis

edited by Ewa Brzeziańska-Lasota

submission deadline 30 Apr 2026 | 3 articles | Viewed by 5989 | Submission Open

Keywords: microbiota; dysbiosis; oncobiome; cell disruptors; cell signaling; epigenetics; diet; dietary intervention; microbiota disorders; cancerogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Neuroblastoma: Molecular Insights and Clinical Implications

edited by Mary Beth Madonna

submission deadline 30 Apr 2026 | 1 articles | Viewed by 4536 | Submission Open

Keywords: neuroblastoma; molecular mechanisms; targeted therapies; immunotherapies; small molecule therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Mesothelioma Epidemiology, Pathogenesis, Emerging Treatments and Pre-Clinical Models

edited by

Francesca Pentimalli

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2819 | Submission Open

Keywords: mesothelioma; epidemiology; pathogenesis; emerging treatments; risk factors; biomarkers; surgical techniques; targeted therapies; immunotherapies; pre-clinical models

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy

edited by

The Phuong Nguyen

submission deadline 30 Apr 2026 | 3 articles | Viewed by 2502 | Submission Open

Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Integrating Bioinformatics, AI, Imaging, and Clinical Informatics in Cancer Research

edited by Jason Li

submission deadline 30 Apr 2026 | 1 articles | Viewed by 2267 | Submission Open

Keywords: bioinformatics; multiomics; genomics; transcriptomics artificial intelligence; deep learning; clinical informatics; medical imaging; functional genomics; multi-discipline

(This special issue belongs to the Section Cancer Informatics and Big Data)

Targeted Therapy in Head and Neck Cancer

edited by

Pietro De Luca

, Angelo Camaioni and Luca de Campora

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1764 | Submission Open

Keywords: salivary glands; thyroid; laryngeal cancer; molecular oncology; reconstruction; microsurgery; oral cancer; HPV; oropharyngeal cancer

(This special issue belongs to the Section Cancer Therapy)

Health Disparities and Outcomes in Cancer Survivors

edited by

Claire Jungyoun Han

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1564 | Submission Open

Keywords: cancer survivorship; quality of life; social behavioral determinants of health (SBDH); health disparities; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Immune Checkpoint Therapy in Liver Cancer: Current Evidence, Underlying Biology, and What's Next

edited by

Luca Marzi

and

Rodolfo Sacco

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1486 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; immuno-oncology; immune checkpoint inhibitors; clinical trial; immunological microenvironments

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation

edited by

Paul T. Thevenot

submission deadline 30 Apr 2026 | 2 articles | Viewed by 982 | Submission Open

Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Exosomes in Cancer Metastasis (2nd Edition)

edited by

Theresa L. Whiteside

submission deadline 30 Apr 2026 | 1 articles | Viewed by 651 | Submission Open

Keywords: exosomes; biomarkers; cancer metastasis

(This special issue belongs to the Section Cancer Metastasis)

Real-World Evidence and Emerging Therapeutic Strategies in Refractory Metastatic Colorectal Cancer

edited by

Carlo Signorelli

submission deadline 30 Apr 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: real-world evidence; refractory metastatic colorectal cancer; treatment resistance; third-line and beyond therapies; targeted therapies; immunotherapy; patient outcomes; clinical practice; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Metastasis)

Advances in Molecular and Genetic Biomarkers in Head and Neck Squamous Cell Carcinoma

edited by

Joanna Katarzyna Strzelczyk

and Michal Masternak

submission deadline 30 Apr 2026 | Viewed by 440 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); molecular biomarkers; genetic biomarkers; multi-omics approaches; HNSCC carcinogenesis; prognostic biomarkers; translational medicine; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Medical Treatment for Urological Cancers

edited by

Jozefina Casuscelli

submission deadline 30 Apr 2026 | Viewed by 374 | Submission Open

Keywords: prostate cancer; urothelial cancer; renal cancer; antibody– drug conjugates; cytotoxic chemotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

Acute Myeloid Leukemia: Updates on Diagnosis, Treatment and Management

edited by

Francesco Lanza

and

Giovanni Marconi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 369 | Submission Open

Keywords: acute myeloid leukemia; treatment; targeted therapy; molecular profiling; resistance

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Molecular Pathogenesis of T-Cell Lymphoma

edited by

Richard Flavin

submission deadline 30 Apr 2026 | Viewed by 360 | Submission Open

Keywords: pathogenesis; molecular biology; T-cell neoplasia/lymphoma; biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Molecular PET Imaging in Cancer Metabolic Studies

edited by

Aditi Mulgaonkar

and

Sashi Debnath

submission deadline 30 Apr 2026 | Viewed by 257 | Submission Open

Keywords: PET imaging; PET/CT; PET/MRI; cancer metabolism; tumor microenvironment; cancer antigens; radiotracers

(This special issue belongs to the Section Methods and Technologies Development)

Targeted Therapies for Pediatric Nervous System Tumors

edited by

Mohamed S. Abdelbaki

and Nicole Brossier

submission deadline 30 Apr 2026 | Viewed by 244 | Submission Open

Keywords: glioma; ependymoma; medulloblastoma; pediatric brain tumors; targeted therapy; MEK inhibitors; NTRK inhibitors; glioma neuroscience; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Pediatric Oncology)

Precision Medicine in Hematological Malignancies: Current Insights and Future Directions

edited by Giuseppe Saglio and Mohamed Yassin

submission deadline 30 Apr 2026 | Viewed by 128 | Submission Open

Keywords: hematological malignancies; precision medicine; targeted therapy; next-generation sequencing; biomarkers; molecular profiling

(This special issue belongs to the Section Cancer Therapy)

From Molecular Insights to Cancer Treatments: Progress in Translational Science

edited by

Sanjay V. Malhotra

, Dhanir Tailor and

Annah Rolig

submission deadline 30 Apr 2026 | Viewed by 96 | Submission Open

Keywords: cancer biology; therapeutics; molecular targets; translational research

(This special issue belongs to the Section Cancer Therapy)

Genetic Screening and Personalized Prevention in Hereditary Gastrointestinal Cancer Syndromes

edited by

Candida Fasano

and Vittoria Disciglio

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: hereditary gastrointestinal cancer syndromes; NGS multigene panel tests; pathogenic variant (PV); variant of uncertain significance (VUS); mismatch repair (MMR) genes; gastrointestinal cancer susceptibility; personalized medicine; genetic risk assessment; germline variants; genetic counseling; functional impact of the genetic variant

(This special issue belongs to the Section Cancer Pathophysiology)

New Insights into Gynecologic Cancer Screenings and Diagnosis, Prognostic and Predictive Biomarkers

edited by Patriciu Achimas-Cadariu and

Laurentia Nicoleta Gales

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: breast cancer screening; cervical cancer screening and prophylaxis; predictive biomarkers in ovarian and endometrial cancer; sentinel lymph node in gynecological cancers

The Changing Paradigms in the Management of Thyroid Cancer

edited by

Antonio M. Matrone

submission deadline 30 Apr 2026 | Viewed by 73 | Submission Open

Keywords: thyroid cancer; targeted therapies; minimally invasive surgery; selective radioiodine use; personalized treatment

(This special issue belongs to the Section Cancer Therapy)

Fatty Acid Synthesis and Mitochondrial Beta-Oxidation in Cancer

edited by

Benny Abraham Kaipparettu

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: fatty acid beta-oxidation (FAO); mitochondrial metabolism; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Stem Cell Origin of Cancers: Biological and Clinical Implications of a Unified Theory of Cancer (2nd Edition)

edited by Shi-Ming Tu, Louis L. Pisters and

John F. Ward

submission deadline 30 Apr 2026 | Viewed by 70 | Submission Open

Keywords: cancer stem cells; cancer-initiating cell; progenitor cell; epithelial; Mesenchymal transition; pluripotency; plasticity; heterogeneity; embryogenesis; stem-like; stemness

(This special issue belongs to the Section Cancer Pathophysiology)

Recent Advances and Strategies for the Management of CIN and HPV Eradication Starategies for the Prevention of Uterine Cervical Cancer

edited by

Masaru Sakamoto

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT

Advances in the Treatment of Urological Cancer

edited by Anna Patrikidou

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: urological oncology; chemotherapy; hormone therapy; immunotherapy; targeted therapy; radioligand therapy; antibody-drug conjugates; novel therapeutics

(This special issue belongs to the Section Cancer Therapy)

CT/MRI/PET in Cancer

edited by

Dávid Sipos

Ritter Zsombor

and

Elif Hindié

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: PET imaging; CT; MRI; cancer; characterization; treatment monitoring; biomarkers; predictive value; AI integration

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Ferroptosis in Cancer (2nd Edition)

edited by Wei Li

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression

(This special issue belongs to the Section Molecular Cancer Biology)

Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies

edited by Giuseppe Marulli

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery

(This special issue belongs to the Section Cancer Therapy)

Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy

edited by

Masaharu Seno

and

Mary J.C. Hendrix

submission deadline 30 Apr 2026 | Viewed by 35 | Submission Open

Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers

edited by

Giorgia Mangili

and

Raffaella Cioffi

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up

(This special issue belongs to the Section Cancer Therapy)

Biomarkers for Therapy Response in Gastrointestinal Malignancies: Predicting Outcomes and Personalizing Care

edited by

Devalingam Mahalingam

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: immunotherapy; biomarkers; resistance mechanisms; predictive markers; clinical trials; translational research

(This special issue belongs to the Section Cancer Biomarkers)

Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications

edited by

Hong Chang

and

Shamila D. Alipoor

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes

(This special issue belongs to the Section Cancer Therapy)

Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition)

edited by

Xavier Sastre-Garau

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA

(This special issue belongs to the Section Infectious Agents and Cancer)

Advances in Locally Advanced and Metastatic Kidney Cancer (2nd Edition)

edited by

Nirmish Singla

and

Yasser Ged

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: kidney cancer; renal cell carcinoma; locally advanced; oligometastatic; metastatic; novel therapeutics; diagnostic imaging; biomarkers; multimodal treatment; cytoreductive nephrectomy

(This special issue belongs to the Section Cancer Metastasis)

PARP Inhibitors in Cancers: 2nd Edition

edited by

Jose Manuel Rodriguez-Vargas

submission deadline 30 Apr 2026 | Viewed by 25 | Submission Open

Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells

(This special issue belongs to the Section Molecular Cancer Biology)

Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life

edited by

Cristina García-Muñoz

Javier Martinez-Calderon

and Juan Carlos Hernández-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 19 | Submission Open

Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)

edited by

Claudia Peitzsch

and

Ina Kurth

submission deadline 30 Apr 2026 | Viewed by 13 | Submission Open

Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance

(This special issue belongs to the Section Cancer Therapy)

Role of Myeloid Cells in the Regulation of Cancer Onset and Development

edited by Rita Campanelli

submission deadline 30 Apr 2026 | Viewed by 12 | Submission Open

Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Image-Guided Treatment of Liver Tumors

edited by

Maarten L. J. Smits

and Niek Wijnen

submission deadline 30 Apr 2026 | Viewed by 11 | Submission Open

Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

Emerging Trends in Health Impact Assessment of Cancer: Innovations in Data Science and Patient-Centered Outcomes

edited by

Gabriela Ilie

submission deadline 30 Apr 2026 | Viewed by 8 | Submission Open

Keywords: health impact assessment; cancer outcomes; data science; machine learning; patient-reported outcomes; realist evaluation; implementation science; clinical trials; health equity; digital health; translational research

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Interrogating Molecular Regulators and Chemical Agents in Brain Tumor Progression

edited by Shilpi Singh

submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open

Keywords: brain tumor progression; molecular mechanisms; small molecule inhibitors; natural compounds; synthetic drugs; biomarkers; oncogenic pathways; metabolic reprogramming

(This special issue belongs to the Section Tumor Microenvironment)

Radical Pelvic Surgery and Reconstructive Innovations in Pelvic Oncology

edited by Evrim Erdemogľu

submission deadline 30 Apr 2026 | Viewed by 2 | Submission Open

Keywords: pelvic exenteration; LEER; radical pelvic surgery; reconstruction; flap surgery; multivisceral resection; gynecologic oncology; pelvic cancer; surgical outcomes; minimally invasive surgery

(This special issue belongs to the Section Clinical Research of Cancer)

Myeloma: Pathogenesis and Targeted Therapies

edited by Fenghuang (Frank) Zhan, Gang An and Cody Ashby

submission deadline 30 Apr 2026 | Submission Open

Keywords: multiple myeloma; drug resistance; car-t cell therapy; immunotherapy targets; biomarkers; genetic alterations; molecular pathogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Virus-Associated Head and Neck Cancer

edited by

Joanna Katarzyna Strzelczyk

submission deadline 1 May 2026 | 3 articles | Viewed by 5677 | Submission Open

Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV

(This special issue belongs to the Section Infectious Agents and Cancer)

Cell Adhesion in Human Cancer

edited by

Takashi Kojima

, Makoto Osanai and

Akira Ikari

submission deadline 1 May 2026 | 2 articles | Viewed by 3117 | Submission Open

Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells

(This special issue belongs to the Section Molecular Cancer Biology)

Displaying special issue 901-950 on page 19 of 23.

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