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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV-Associated Lymphoid Neoplasms (2nd Edition)

edited by

José-Tomás Navarro

and

Kai Hübel

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1079 | Submission Open

Keywords: B-cell lymphoma; HIV; AIDS; Epstein–Barr virus; epidemiology; pathogenesis; prognosis

(This special issue belongs to the Section Infectious Agents and Cancer)

Advanced Immunotherapeutic Strategies and Clinical Developments in Hepatocellular Carcinoma and Gastrointestinal Cancers

edited by Kaushik Banerjee, Shayanki Lahiri and Lei Yang

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1068 | Submission Open

Keywords: hepatocellular carcinoma; gastrointestinal cancers; clinical immunotherapy; immune checkpoint inhibitors; tumor immune microenvironment; biomarkers and precision oncology; immunotherapy resistance; immune-related adverse events; combination therapy; CAR-T and adoptive cell therapy; cancer vaccines; translational and clinical research; clinical trials; real-world evidence

Cellular Plasticity, Metabolic Adaptations and Therapeutic Strategies in Breast Cancer

edited by

Kunwar Somesh Vikramdeo

submission deadline 20 Feb 2027 | Viewed by 511 | Submission Open

Keywords: breast cancer; cellular plasticity; metabolic reprogramming; tumor microenvironment; therapy resistance; epithelial–mesenchymal transition (EMT); cancer stem cells; redox metabolism; mitochondrial pathways; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by

Nicolas Nassar

submission deadline 20 Feb 2027 | Viewed by 452 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Digital Health Technologies in Oncology: 2nd Edition

edited by

Sorana D. Bolboacă

submission deadline 25 Feb 2027 | Viewed by 600 | Submission Open

Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics.

(This special issue belongs to the Section Methods and Technologies Development)

The Tumorigenesis Mechanism of Breast Cancer

edited by Swayam Prabha

submission deadline 25 Feb 2027 | Viewed by 449 | Submission Open

Keywords: breast cancer; tumor microenvironment; myeloid-derived suppressor cells; immune evasion; premetastatic niche; epithelial–mesenchymal transition; PI3K/AKT/mTOR; MAPK/ERK; Wnt/β-catenin; BRCA1/2; TP53; estrogen signaling; targeted therapy; nanomedicine; biologics; precision oncology; translational research

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Peptidases in Cancer

edited by

Natalia A. Ignatenko

submission deadline 25 Feb 2027 | Viewed by 336 | Submission Open

Keywords: signaling proteases; proteolytic pathways; proteases and tumor microenvironment; protease diagnostic and therapeutic modalities in cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements in “Cancer Biomarkers” for 2025–2026

edited by

Maxim V. Berezovski

submission deadline 28 Feb 2027 | 23 articles | Viewed by 42173 | Submission Open

Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis

(This special issue belongs to the Section Cancer Biomarkers)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 28 Feb 2027 | 2 articles | Viewed by 6894 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 28 Feb 2027 | 4 articles | Viewed by 6643 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 28 Feb 2027 | 3 articles | Viewed by 6429 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Novel Diagnostic and Therapeutic Approaches in Urologic Oncology

edited by

Whi-An Kwon

submission deadline 28 Feb 2027 | 1 articles | Viewed by 5793 | Submission Open

Keywords: urologic oncology; liquid biopsy; immunotherapy; artificial intelligence; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor Microenvironment in Cancer Therapies: Supportive or Hostile?

edited by

Constantin N. Baxevanis

submission deadline 28 Feb 2027 | 1 articles | Viewed by 3361 | Submission Open

Keywords: tumor microenvironment; protumor effects; antitumor effects; immune cells; stromal cells; extracellular matrix; cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Integrating Chemotherapy and Immunotherapy for Head and Neck Cancer

edited by Ken Saijo

submission deadline 28 Feb 2027 | 1 articles | Viewed by 3166 | Submission Open

Keywords: head and neck squamous cell carcinomas; HNSCC; immune checkpoint inhibitor; biomarker; chemotherapy

(This special issue belongs to the Section Cancer Metastasis)

Surgery for Lung Cancer: Robot-Assisted Versus Video-Assisted Thoracoscopic Surgery and Open Thoracotomy

edited by

Mariusz Chabowski

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2816 | Submission Open

Keywords: laparoscopic thoracic surgery; open thoracotomy; robotic thoracic surgery (RTS); lung cancer; surgical treatment; minimally invasive intervention

(This special issue belongs to the Section Cancer Therapy)

Advanced Segmentation in Multimodal Nuclear Imaging of Solid Tumors and Lymphomas: Tools, Challenges, and Clinical Integration

edited by

Ken Kudura

and Robert Förster

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2424 | Submission Open

Keywords: multimodal nuclear imaging; artificial intelligence in nuclear medicine; radiomics in nuclear medicine; tumor segmentation; segmentation techniques; segmentation tools; outcome prediction; radioligand therapy

(This special issue belongs to the Section Methods and Technologies Development)

Transformative Genomic Technologies Shaping the Future of Precision Approaches for Haematological Malignancies

edited by

Chung Hoow Kok

and

Barbara McClure

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2379 | Submission Open

Keywords: multi-omics; risk stratification; bioinformatics; AI/machine learning; hematological malignancies; biomarkers; targeted therapeutics; genomics; cancer cell biology

Decoding the Tumor Microenvironment: Immune Cell–Tumor Interplay in Breast Cancer

edited by Abirami Sivapiragasam and Roberto A. Leon Ferre

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2072 | Submission Open

Keywords: tumor microenvironment; breast cancer; immune cell–tumor interaction; immunotherapy; T cells; macrophages; dendritic cells; single-cell transcriptomics; spatial transcriptomics; artificial intelligence; prognostic biomarkers; predictive biomarkers; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Minimally Invasive and Innovative Approaches in Breast Cancer Surgery: Techniques and Outcomes

edited by

Vasileios C. Kalles

and

Ioannis K. Papapanagiotou

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2068 | Submission Open

Keywords: minimally invasive breast surgery; endoscopic mastectomy; robotic mastectomy; targeted axillary dissection; breast-conserving surgery; breast reconstruction; cryoablation; surgical outcomes; patient-reported outcomes; quality of life

(This special issue belongs to the Section Clinical Research in Cancer)

Role of Inflammation in Cancer

edited by

Li Yang

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1966 | Submission Open

Keywords: cancer; inflammation; immune cells; cytokines; anti-inflammatory; tumor microenvironment; immunotherapy; immune-related adverse events; targeted therapy; chemotherapy and chemoprevention

Molecular Mechanisms and Therapeutic Resistance in Hematological Malignancies

edited by

Rui Bergantim

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1951 | Submission Open

Keywords: genomic and epigenomic alterations; signaling pathway dysregulation; non-coding RNAs; metabolic reprogramming; antigen escape mechanisms; antigen presentation defects; interferon signaling impairment; T-cell exhaustion; memory T-cell dysfunction; myeloid-mediated immunosuppression; bone marrow immune microenvironment; spatial immune architecture; CAR-T cell therapy; next-generation CAR engineering; bispecific antibodies and T-cell engagers; antibody-drug conjugates; NK-cell and macrophage immunotherapy; immune checkpoint modulation; combination immunotherapy strategies; liquid biopsy–guided precision therapy

Next-Generation Biomarkers and AI-Enhanced Digital Pathology Alliance: Revolutionizing Therapeutic Strategies and Prognostic Assessment in Colorectal Cancer

edited by

Τaxiarchis Κonstantinos Νikolouzakis

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1827 | Submission Open

Keywords: liquid biopsy; precision oncology; predictive prognostication

Surgery for Head and Neck Cancer

edited by

Boban M. Erovic

Blazen Marijic

and Stefan Grasl

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1453 | Submission Open

Keywords: head and neck cancer; oncologic surgery; minimally invasive surgery; transoral robotic surgery; neck dissection; reconstructive surgery; multidisciplinary treatment; functional outcomes

(This special issue belongs to the Section Cancer Therapy)

Advances in Treatment of Bladder Cancer

edited by

Murat Akand

and

Guglielmo Mantica

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1358 | Submission Open

Keywords: bladder cancer; diagnostic biomarkers; genomics; therapeutic approaches

(This special issue belongs to the Section Cancer Therapy)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1259 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Molecular Biology of Cholangiocarcinoma

edited by

Kevin Gaston

and Padma-Sheela Jayaraman

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1258 | Submission Open

Keywords: cholangiocarcinoma; biliary tract cancer; early detection; targeted therapy; tumour microenvironment; spatial biology; genomics; transcriptomics; proteomics

(This special issue belongs to the Section Molecular Cancer Biology)

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1067 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

mTOR Signaling in Cancer

edited by

Don Benjamin

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1049 | Submission Open

Keywords: mTOR; cancer; cell signaling; pathway addiction; tumor metabolism; glycolysis; autophagy; apoptosis; rapamycin

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular Insights into Drug Resistance in Cancer: 2nd Edition

edited by Yuqi Yang

submission deadline 28 Feb 2027 | 2 articles | Viewed by 899 | Submission Open

Keywords: drug resistance; cancer treatment; molecular mechanism; chemotherapeutic therapy; small molecules; biologics/large molecules; leukemia; solid tumor

Role of TP53 Mutation in Cancer

edited by

Naoyuki Iwahashi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 854 | Submission Open

Keywords: TP53 mutation; p53 aggregate; gain-of-function; cancer progression; transcriptional reprogramming; therapeutic targeting; biomarker; translational research; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Redox Balance, Antioxidant Defenses, and Inflammation in Cancer: From Initial Changes to Tumor Progression

edited by Andrej Veljković,

Gordana Kocic

and

Aleksandra Klisic

submission deadline 28 Feb 2027 | 1 articles | Viewed by 839 | Submission Open

Keywords: oxidative stress; inflammation; cancer progression; pre-malignant changes; biomarkers; tumor microenvironment; cell signaling; therapeutic targets

(This special issue belongs to the Section Tumor Microenvironment)

Robotic and Thoracoscopic Surgery for Lung Cancer

edited by Benjamin Wei

submission deadline 28 Feb 2027 | 1 articles | Viewed by 611 | Submission Open

Keywords: robotic; thoracoscopic; lobectomy; segmentectomy; wedge resection; lymph node dissection; neoadjuvant therapy; immunotherapy; spread through air spaces; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Treatment and Prognosis of Hepato-Biliary and Pancreatic Tumors—the Role of Minimally Invasive Surgery

edited by Giorgio Ercolani

submission deadline 28 Feb 2027 | 1 articles | Viewed by 497 | Submission Open

Keywords: liver tumor; cholangiocarcinoma; pancreatic tumor; robotic surgery; mini-invasive treatment; treatment multimodality

Recent Developments on PET-CT in Multiple Myeloma

edited by

Carmelo Caldarella

submission deadline 28 Feb 2027 | Viewed by 417 | Submission Open

Keywords: PET/CT; multiple myeloma; novel radiopharmaceuticals; radiomics; theranostics

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Multimodal Management of Pancreatic Ductal Adenocarcinoma

edited by

Olav F. Dajani

Knut Jørgen Labori

and

Arne Westgaard

submission deadline 28 Feb 2027 | Viewed by 396 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); multimodal approach; systemic therapy; radiotherapy; targeted strategies; neoadjuvant therapy; adjuvant therapy

(This special issue belongs to the Section Cancer Therapy)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 28 Feb 2027 | Viewed by 351 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Tumor Microenvironment in Bone Sarcoma

edited by

Fan Shen

and

Consolato M. Sergi

submission deadline 28 Feb 2027 | Viewed by 347 | Submission Open

Keywords: osteosarcoma; microenvironment; oncogene; tumor suppressor; CAR cell therapy; epithelial–mesenchymal transition; metabolism; epigenetics

(This special issue belongs to the Section Tumor Microenvironment)

Next-Generation Biomarkers in Oncology: From Multi-Omics to AI-Powered Diagnostics

edited by

Caroline G. Lee

submission deadline 28 Feb 2027 | Viewed by 328 | Submission Open

Keywords: multi-omics; cancer biomarkers; precision oncology; liquid biopsy; circulating tumor DNA (ctDNA); single-cell sequencing; spatial transcriptomics; epigenomics; proteogenomics; metabolomics; tumor microenvironment; radiomics; digital pathology; machine learning; explainable AI

(This special issue belongs to the Section Cancer Biomarkers)

Digital Pathology and AI for Tumor Microenvironment Mapping

edited by Mohammadreza Azimi

submission deadline 28 Feb 2027 | Viewed by 314 | Submission Open

Keywords: tumor microenvironment; digital pathology; artificial intelligence; spatial analysis; computational histopathology; deep learning; cancer prognostics; machine learning; image-based biomarkers; federated learning

Non-Coding RNAs in Bone Tumors: Pathogenesis, Diagnostic Biomarkers, and Therapeutic Perspectives

edited by Albert Roessner

submission deadline 28 Feb 2027 | Viewed by 176 | Submission Open

Keywords: bone tumors; non-coding RNAs; pathogenesis; biomarkers; non-coding RNA therapeutics

Emerging Roles of HDACs in Cancer Metabolism, Plasticity and Therapeutic Response

edited by Changmin Peng

submission deadline 28 Feb 2027 | Viewed by 172 | Submission Open

Keywords: HDAC biology; cancer metabolism; therapeutic resistance; post-translational modifications; cancer plasticity

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Pathology of Lymphoma and Leukemia—Second Edition

edited by

Siba El Hussein

submission deadline 28 Feb 2027 | Viewed by 131 | Submission Open

Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis

(This special issue belongs to the Section Cancer Pathophysiology)

Signaling Molecules for Brain Tumors

edited by

Meenakshisundaram Kandhavelu

and Akshaya Murugesan

submission deadline 28 Feb 2027 | Viewed by 124 | Submission Open

Keywords: brain tumor; signaling molecules; tumor microenvironment; sensor; diagnosis and treatment; tumor microenvironment; synthesis and characterization; small drug molecules; gene expression; computational studies

(This special issue belongs to the Section Molecular Cancer Biology)

Photodiagnosis and Photodynamic Therapy for CNS Tumors

edited by

Jiro Akimoto

submission deadline 28 Feb 2027 | Viewed by 118 | Submission Open

Keywords: photo-diagnosis; photodynamic therapy; central nervous system tumors; photosensitizer

The Roles of microRNAs and Long Non-Coding RNAs in Cancer

edited by

Mohammad Taheri

submission deadline 28 Feb 2027 | Viewed by 116 | Submission Open

Keywords: microRNAs; long non-coding RNAs; non-coding RNAs; cancer genomics; gene regulation; competing endogenous RNA; tumor microenvironment; therapy resistance; cancer biomarkers; single-cell and multi-omics

(This special issue belongs to the Section Molecular Cancer Biology)

Quality of Life and Management of Pediatric Cancer (2nd Edition)

edited by

Luca Giacomelli

and

Momcilo Jankovic

submission deadline 28 Feb 2027 | Viewed by 95 | Submission Open

Keywords: pediatric palliative care; oncology; quality of life; early management

(This special issue belongs to the Section Pediatric Oncology)

Minimally Invasive Treatments for Prostate Cancer

edited by Javier Romero-Otero

submission deadline 28 Feb 2027 | Viewed by 66 | Submission Open

Keywords: prostate cancer; robotic surgery; focal therapy; single-port surgery; artificial intelligence

(This special issue belongs to the Section Cancer Therapy)

Chemo-Radio-Immunotherapy for Colorectal Cancer: 2nd Edition

edited by Shoichi Hazama

submission deadline 28 Feb 2027 | Viewed by 66 | Submission Open

Keywords: colorectal cancer; immunotherapy; chemotherapy; radiotherapy; combination therapy; neoadjuvant therapy; biomarkers for treatment response; anal cancer; squamous cell carcinoma; minimally invasive surgery; conversion surgery

(This special issue belongs to the Section Cancer Therapy)

The Role of PSMA PET/CT in Prostate Cancer Therapy and Prognosis

edited by

Marco Cuzzocrea

and Gennaro Cusato

submission deadline 28 Feb 2027 | Viewed by 64 | Submission Open

Keywords: PSMA PET/CT; prostate cancer; radioligand therapy; [177Lu]Lu-PSMA; theranostic; treatment response assessment; prognostic biomarkers; metastatic castration-resistant prostate cancer; patient selection; quantitative imaging

Emerging Therapies and Non-Pharmacologic Interventions for Lymphoma Treatment

edited by Max J. Gordon

submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open

Keywords: non-hodgkin lymphoma; hodgkin lymphoma; targeted therapy; immunotherapy; epigenetic drugs; T-cell lymphoma; B-cell lymphoma; energy balance; body composition; cellular therapy

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 901-950 on page 19 of 22.

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