Immunoediting in Cancer Therapies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 715

Special Issue Editor


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Guest Editor
Laboratory of Tumor Immunology and Immunotherapy, Department of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA
Interests: innate immunity; tumor immunology; immunometabolism; obesity-associated immunological changes

Special Issue Information

Dear Colleagues,

Cancer cells develop immune escape or avoidance characteristics to achieve uninterrupted growth, proliferation, and metastasis or spread to distant organs. This immune escape of cancer cells is called cancer immunosurveillance. In addition to cancer immunosurveillance, which is only one dimension of a cancer and immune system relationship. For example, along with cancer immunosurveillance, they also induce a process called cancer immunoediting, where cancer cells modify the anti-tumor immune response and immune cells to support their growth, proliferation and metastasis. The cancer immunoediting phase comprises three potential Es: elimination, equilibrium and escape. The elimination phase comprises classical immunosurveillance, the equilibrium phase comprises the period of immune-mediated latency due to incomplete destruction of cancer cells during the elimination phase, and the escape phase includes final tumor growth by overcoming/limiting the antitumor immune response during the equilibrium phase. Thus, understanding cancer immunoediting is critical to develop novel immunomodulatory and immunotherapies. This Special Issue is a good platform for researchers involved in cancer immunotherapies and understating the cancer immunoediting to design better immunotherapies.

Dr. Vijay Kumar
Guest Editor

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Keywords

  • cancer
  • cancer immunology
  • immunosurveillance
  • immunoediting
  • immunotherapy
  • immunomodulation
  • immunometabolism

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Published Papers (1 paper)

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Review

10 pages, 2191 KiB  
Review
The Natural Killer Cell Line NK-92 and Its Genetic Variants: Impact on NK Cell Research and Cancer Immunotherapy
by Hans Klingemann
Cancers 2025, 17(12), 1968; https://doi.org/10.3390/cancers17121968 - 13 Jun 2025
Viewed by 298
Abstract
The NK-92 cell line has become a very relevant tool for natural killer (NK) cell research, largely because it largely mirrors the characteristics of human blood-derived NK cells. It also has a doubling time of less than 30 h, making it possible to [...] Read more.
The NK-92 cell line has become a very relevant tool for natural killer (NK) cell research, largely because it largely mirrors the characteristics of human blood-derived NK cells. It also has a doubling time of less than 30 h, making it possible to generate a significant number of cells in a relatively short time. Its safety as an anti-cancer cell therapy has been documented in over 200 cancer patients. Various genetically engineered variants have been generated that express a high-affinity Fc-receptor and various chimeric antigen receptors (CARs) and secrete immune-active cytokines. NK-92 cells expressing CARs for HER-2, PD-L1, and CD19 CAR are in advanced clinical trials in cancer patients. These cells also have cytotoxic activity against targets infected with bacteria, fungi, and viruses. More recently, the cellular lysate of NK-92 cells, generated by simple freeze/thaw, has shown anti-cancer potential when injected intra-tumor. Since a comprehensive review of NK-92 was recently published on the occasion of its 30-year “anniversary”, this review will focus on more recent research initiatives and results with the cell line. Full article
(This article belongs to the Special Issue Immunoediting in Cancer Therapies)
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