Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy: 2nd Edition

Dear Colleagues,

This Special Issue is the second edition of a previous issue on the topic of "Molecular Tumor Boards: Promise and Limitations for Personalized Cancer Therapy” (https://www.mdpi.com/journal/cancers/special_issues/personalized_cancer_therapy).

The idea of adapting cancer therapy to the specific molecular features of a tumor is changing the way we treat cancer, especially advanced cancer. Such features are discussed in dedicated molecular tumor boards (MTBs) in which experts from different fields (such as bioinformatics, molecular oncology, and molecular biology) work together with clinicians to select the best therapy for individual patients. Although this concept is finding its way into hospitals all across the world, several limitations may make this approach ineffective. While the development of resistances is a logical limitation of targeted therapies, other challenges reflect our difficulty to deal with multiple and often uncharacterized alterations, the lack of inhibitors for some driver mutations, and technological pitfalls.

With this Special Issue, we aim to present single and multicenter experiences to introduce new methodologies or algorithms to identify actionable aberrations and to discuss new theories on cancer biology that may translate into a clinical application.

Prof. Dr. Claudia Paret
Guest Editor

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