Innovative and Personalized Approaches to Improve Patient Outcomes in Gynecological Oncology

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 1174

Special Issue Editors


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Guest Editor
Department of Gynaecological Oncology, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK
Interests: gynaecological oncology; prehabiltation; lifestyle; radical surgery; robotic surgery

E-Mail Website
Guest Editor
Department of Gynaecological Oncology, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK
Interests: gynaecological oncology; prehabiltation; lifestyle; radical surgery; robotic surgery

Special Issue Information

Dear Colleagues,

The management of gynecological cancers is transitioning away from standardized treatment towards a more holistic and individualized management of patients and cancer. Individual patient factors such as comorbidities, body mass index, fitness and other lifestyle factors are being increasingly recognized as modifiable factors that can improve patient outcomes. Innovative initiatives such as prehabilitation, enhanced recovery and survivorship care are gaining increasing traction within gynecological oncology. In addition, continuous efforts are being made to minimize treatment morbidity and long-term sequalae of survivors through decreasing the radicality of surgery, advances in radiation delivery and new systemic treatment options.

This Special Issue welcomes submissions that contain original research focusing on improving the personalization of gynecological cancer treatment across surgical, medical and clinical oncology fields, as well as studies that focus on improving long-term survival outcomes and the quality of life of gynecological cancer survivors.

The Guest Editors of this Special Issue look forward to receiving your contributions.

Dr. Anke Smits
Dr. James Dilley
Guest Editors

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Keywords

  • gynecological cancer
  • lifestyle
  • prehabilitation
  • rehabilitation
  • survival
  • quality of life

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Published Papers (1 paper)

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Research

13 pages, 1179 KiB  
Article
Is Cardiopulmonary Exercise Testing Predictive of Survival Outcomes in Patients Undergoing Surgery for Ovarian Cancer?
by Velangani Bhavya Swetha Rongali, Joanne Knight, Chloe Banfield, Porfyrios Korompelis, Stuart Rundle and Anke Smits
Cancers 2025, 17(9), 1460; https://doi.org/10.3390/cancers17091460 - 26 Apr 2025
Viewed by 1021
Abstract
Preoperative cardiopulmonary exercise testing (CPET) provides an objective measure of a patient’s functional capacity under stress. However, the association between CPET and long-term outcomes for women with ovarian cancer have not been assessed. The aim was to determine whether cardiorespiratory fitness, as measured [...] Read more.
Preoperative cardiopulmonary exercise testing (CPET) provides an objective measure of a patient’s functional capacity under stress. However, the association between CPET and long-term outcomes for women with ovarian cancer have not been assessed. The aim was to determine whether cardiorespiratory fitness, as measured by CPET parameters—peak oxygen uptake (VO2 peak), ventilatory efficiency at anaerobic threshold (VE/VCO2 at AT), and anaerobic threshold (AT)—could predict overall survival (OS) and recurrence -free survival (RFS) in patients with all stages of ovarian cancer. Methods: This was a retrospective cohort study of patients who underwent CPET prior to surgery for suspected or confirmed ovarian cancer during 2019–2023 at the Northern Gynaecological Oncology Centre, United Kingdom. CPET outcomes were risk-stratified, with thresholds of AT ≥ 10 mL/min, VO2 peak ≥ 15 mL/kg/min, and VE/VCO2 at AT ≤ 34 indicating lower risk. Primary outcomes included OS and RFS. Results: A total of 303 patients were included, of whom 56 (18.5%) had a staging laparotomy, 130 (42.9%) underwent primary cytoreductive surgery, and 117 (38.6%) underwent interval cytoreductive surgery. Survival analysis showed that VO2 peak ≥ 15 was significantly associated with improved OS of the whole population (p = 0.032). VE/VCO2 at AT ≤ 34 was associated with improved survival in patients with advanced stage disease (p = 0.025) after ovarian cancer surgery. There was no association between CPET parameters and RFS. Conclusions: We found that peak VO2 ≥ 15 was associated with improvement of overall survival in patients with all stages of ovarian cancer. In addition, VE/VCO2 at AT ≤ 34 was associated with overall survival in patients with advanced-stage disease. Full article
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