Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management: 2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 583

Special Issue Editor


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Guest Editor
Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid, Spain
Interests: hematologic malignancies; multiple myeloma; next generation sequencing; molecular heterogeneity
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Special Issue Information

Dear Colleagues,

Many studies have demonstrated multiple myeloma (MM) to be a complex and heterogeneous disease with many genetic events that impact patients’ prognoses. Next-generation sequencing allows for the understanding and classification of MM’s genomic landscape in which the presence of “high-risk” features keeps predicting poorer outcomes regardless of the effectiveness of novel treatments. Multiple myeloma is thus still considered incurable, although recent clinical trials have shown promising results regarding the stabilization of the disease, furthering the five-year threshold. However, many features still require consideration with the rise in improved disease monitorization through minimal residual disease analysis and its association with relapse probability.

This is the second edition of this Special Issue. We welcome research articles and review papers that focus on a wide scope of multiple myeloma, ranging from basic pathology to preclinical and clinical studies. You may read the publications in the first edition at Multiple Myeloma: Recent Advances in Diagnosis, Analysis and Therapeutic Management. 

Dr. Juan Manuel Rosa-Rosa
Guest Editor

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Keywords

  • multiple myeloma (MM)
  • hematologic malignancies
  • next-generation sequencing
  • heterogeneous disease
  • tumor heterogeneity
  • genomic landscape
  • outcomes
  • novel treatments
  • clinical trial

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Published Papers (1 paper)

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Review

25 pages, 481 KiB  
Review
Advances in Supportive Care for Multiple Myeloma-Related Bone Disease—A Review
by Saadia Abbas, Haleema Sadia Adil, Shahzad Raza, Janita Basit, Karan Arul, Faiz Anwer and Muhammad Hamza Habib
Cancers 2025, 17(13), 2166; https://doi.org/10.3390/cancers17132166 - 27 Jun 2025
Viewed by 440
Abstract
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by the increased production of monoclonal immunoglobulin. Patients with MM are at high risk of suffering from disease-related complications. Osteolytic bone disease is one of the most common disease-related complications, resulting in chronic [...] Read more.
Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by the increased production of monoclonal immunoglobulin. Patients with MM are at high risk of suffering from disease-related complications. Osteolytic bone disease is one of the most common disease-related complications, resulting in chronic pain and skeletal pathologies that contribute significantly to high morbidity and mortality rates among MM patients. In addition to standard anti-MM therapy, management of disease-related sequelae is integral to improving quality of life in MM patients. Bisphosphates have long been the mainstay treatment for patients with myeloma bone disease (MBD) due to their ability to reduce the incidence of skeletal-related adverse events. However, in recent years, a deeper understanding of the complex biology and pathophysiology associated with myeloma bone disease has led to the development of novel therapies that have the potential to improve MM patient management and outcomes. This narrative review uses the most recent extant publications to review all such advancements. It aims to summarize evidence-based strategies for the management of myeloma bone disease and therapy-associated adverse events whilst highlighting current guidelines on optimal bisphosphonate use and providing an overview of promising new agents currently in clinical development. Full article
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