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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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EVs and EPS in Cancer: Cell-to-Cell Communication, Diagnosis, and Evaluation of Cancer Therapy Response

edited by Irina Nazarenko and

José Antonio López-Guerrero

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1941 | Submission Open

Keywords: extracellular vesicles; EVs; particles; cancer; liquid biopsy; cell-cell communication

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Spinal Tumoral Pathology: Surgical Perspectives and Multidisciplinary Therapeutic Approaches

edited by

Ştefan Florian

submission deadline 20 Jul 2025 | Viewed by 97 | Submission Open

Keywords: spinal tumors; oncological surgery; spinal oncology; minimally invasive techniques; multidisciplinary treatment; targeted therapy; patient outcomes in spinal surgery; imagine techniques in spinal tumors; surgical robotics in spinal tumor resection; neuromonitoring

(This special issue belongs to the Section Cancer Pathophysiology)

Epigenetic Therapeutic Targets in Cancer

edited by

Sibaji Sarkar

submission deadline 24 Jul 2025 | Viewed by 84 | Submission Open

Keywords: epigenetics; targets; cancer; tumor; signaling regulation; inhibitors; drugs

(This special issue belongs to the Section Cancer Therapy)

State of the Art: Cardiothoracic Tumors

edited by

Calvin Sze Hang Ng

and Panagiotis Tasoudis

submission deadline 25 Jul 2025 | 3 articles | Viewed by 2055 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; esophageal cancer; diagnostic imaging; robotic-assisted thoracoscopic surgery; video-assisted thoracoscopic surgery; immunotherapy; radiotherapy; molecular oncology; lung cancer screening

(This special issue belongs to the Section Cancer Therapy)

Immune Microenvironment and Immunotherapy in Malignant Brain Tumors

edited by Masaki Terabe and

Mark R. Gilbert

submission deadline 25 Jul 2025 | Viewed by 56 | Submission Open

Keywords: glioma; brain metastasis; primary brain cancer; tumor immunity; neuroimmunology; immune microenvi-ronment; T cells; myeloid cells; cancer neuroscience

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Liver Resection and Liver Transplantation for Hepatocellular Carcinoma

edited by Satoshi Ogiso

submission deadline 25 Jul 2025 | Viewed by 37 | Submission Open

Keywords: hepatocellular carcinoma; liver transplantation; liver resection

(This special issue belongs to the Section Transplant Oncology)

New Approaches to Biology and Treatment of Acute Leukemia

edited by Régis Thierry Costello and

Laure Farnault

submission deadline 30 Jul 2025 | 6 articles | Viewed by 10518 | Submission Open

Keywords: acute leukemia; targeted therapy; single-cell analysis; theranostic; high-throughput molecular biology

(This special issue belongs to the Section Cancer Therapy)

Cancer Cells Fostered Microenvironment in Metastasis

edited by Lin Ye

submission deadline 30 Jul 2025 | 2 articles | Viewed by 3987 | Submission Open

Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy

(This special issue belongs to the Section Cancer Metastasis)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2199 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

State of the Art and Novelties in Multidisciplinary Approach to Soft Tissue and Bone Sarcomas

edited by Ron Batash, Alberto Crimì, Moshe Schaffer and

Pietro Ruggieri

submission deadline 30 Jul 2025 | Viewed by 155 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; treatment; diagnosis; radiation therapy; chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Insights into Lymphoma Treatment

edited by Irit Avivi

submission deadline 30 Jul 2025 | Viewed by 67 | Submission Open

Keywords: treatment; non hodgkin lymphoma; diffuse large cell lymphoma; follicular lymphoma; mantle cell lymphoma; CAR-T cell therapy; bispecific antibodies; BTK-inhibitors; BCL-2 inhibitors

(This special issue belongs to the Section Cancer Therapy)

Updates on Gene Expression Analyses in Anti-Cancer Drug Research

edited by

Ana Luísa De Sousa-Coelho

and Mónica Fernandes

submission deadline 30 Jul 2025 | Viewed by 48 | Submission Open

Keywords: gene expression profiling; anti-cancer drug research; drug resistance; biomarkers; pharmacogenomics; single-cell RNA sequencing; non-coding RNAs; multi-omics data

(This special issue belongs to the Section Cancer Drug Development)

Updates on Thyroid Cancer

edited by

Kwangsoo Kim

and

Ja Seong Bae

submission deadline 30 Jul 2025 | Viewed by 40 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

Targeted Therapies for Cancer Metastasis

edited by

Katrien Remaut

and

Wim P. Ceelen

submission deadline 31 Jul 2025 | 5 articles | Viewed by 11922 | Submission Open

Keywords: nucleic acids in cancer treatment (siRNA; mRNA; pDNA; … ); antibodies in cancer treatment; immunotherapy; cancer vaccines; cancer gene therapy; cell based therapy; tumor environment responsive materials; controlled release formulations; locoregional triggered drug delivery; delivery barriers to targeted cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Cancer and Immunomediated Inflammatory Diseases (IMIDs)

edited by

Sandro Ardizzone

submission deadline 31 Jul 2025 | 3 articles | Viewed by 3071 | Submission Open

Keywords: cancer risk; IMIDs; autoinflammatory diseases; autoimmune diseases; immune-mediated inflammatory diseases; immune-regulatory mechanism; carcinogenesis

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Exploiting Liabilities in Mechanism of DNA Repair for Cancer Therapy

edited by

Arrigo De Benedetti

, Mariarita de Felice and Mariarosaria de Falco

submission deadline 31 Jul 2025 | 1 articles | Viewed by 1159 | Submission Open

Keywords: mechanisms of DNA repair; DDR; targeted radio- and chemotherapies; mechanisms of genotoxins tolerance/resistance; synthetic lethality

(This special issue belongs to the Section Molecular Cancer Biology)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors

edited by

Annabella Di Mauro

Ottavia Clemente

and

Salvatore Tafuto

submission deadline 31 Jul 2025 | Viewed by 214 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

(This special issue belongs to the Section Cancer Therapy)

Integrative Histopathological–Molecular–Computational Analysis of Primary Brain Tumors

edited by

Adriana Olar

submission deadline 31 Jul 2025 | Viewed by 209 | Submission Open

Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

Novel Diagnosis and Treatment Approaches in Pancreatic Cancer

edited by

Atsushi Masamune

submission deadline 31 Jul 2025 | Viewed by 144 | Submission Open

Keywords: pancreatic cancer; pancreatic fibrosis; biomarker; risk factor; genetic testing; artificial intelligence; endoscopic ultrasound; stroma; cancer-associated fibroblasts; familial pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Emerging Research in Primary Brain Tumor

edited by Jacob S Young and Mitchel S. Berger

submission deadline 31 Jul 2025 | Viewed by 134 | Submission Open

Keywords: molecular biomarkers; drug delivery; immunotherapy; personalized medicine; targeted therapies; glioma

(This special issue belongs to the Section Cancer Therapy)

Heterogeneity in Intra-cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications

edited by

Francois Ducray

, Shawn L. Hervey-Jumper and Thiebaud Picart

submission deadline 31 Jul 2025 | Viewed by 93 | Submission Open

Keywords: glioma; histo-molecular classification; intra-tumoral heterogeneity; inter-tumoral heterogeneity; meningioma; neuro-oncology; neurosurgery

(This special issue belongs to the Section Cancer Metastasis)

Cancer Induced Organ Dysfunctions (Cachexia)

edited by

Sham S. Kakar

and Sarama Saha

submission deadline 31 Jul 2025 | Viewed by 87 | Submission Open

Keywords: cancer; cachexia; organ dysfunction; cancer-induced cachexia; cancer-induced organ dysfunction; muscle wasting

(This special issue belongs to the Section Molecular Cancer Biology)

Applications of Single-Cell Genomics in Cancer Research

edited by Clelia Peano

submission deadline 31 Jul 2025 | Viewed by 81 | Submission Open

Keywords: single-cell genomics; spatial transcriptomics; spatial multi-omics analysis; gene expression; tumor microenvironment

(This special issue belongs to the Section Methods and Technologies Development)

Evolving Understanding of the Epidemiology of Thyroid Cancer

edited by

Marco Capezzone

and

Anello Marcello Poma

submission deadline 31 Jul 2025 | Viewed by 80 | Submission Open

Keywords: thyroid cancer; epidemiology; incidence; time trends; mortality

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Mediastinum—Pandora’s Box

edited by

Cesar A. Moran

submission deadline 31 Jul 2025 | Viewed by 75 | Submission Open

Keywords: mediastinum; thymus; imaging; surgery; thymoma; germ cell tumors

Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically

edited by

Vaishali Aggarwal

and Alok Kumar

submission deadline 31 Jul 2025 | Viewed by 67 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Medical Complications and Supportive Care in Patients with Cancer (2nd Edition)

edited by

Javier Marco-Hernández

submission deadline 31 Jul 2025 | Viewed by 52 | Submission Open

Keywords: cancer; oncological emergencies; immune-related adverse events; immunotherapy; supportive care; palliative care; infectious diseases; thromboembolic disease; treatment; toxicities; CAR-T cell therapy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Thyroid Cancer: Diagnosis, Prognosis and Treatment (2nd Edition)

edited by Luca Giovanella and Petra Petranović Ovčariček

submission deadline 31 Jul 2025 | Viewed by 35 | Submission Open

Keywords: thyroid cancer; ultrasound; molecular imaging; fine-needle aspiration cytology; thyroidectomy; radioactive iodine; radioiodine-refractory thyroid cancer; tyrosine kinase inhibitors

(This special issue belongs to the Section Cancer Therapy)

Molecular and Cellular Heterogeneity in an Evolving Tumor Landscape: When Diversity Gives Rise to Aggressive and Drug-Resistant Cells (2nd Edition)

edited by

Michelle R. Dawson

submission deadline 31 Jul 2025 | Viewed by 32 | Submission Open

Keywords: single-cell analysis; intratumor heterogeneity; spatial heterogeneity; epithelial-to-mesenchymal transition (EMT); metastatic cancer cells; tumor microenvironment interactions; chemoresistant cell phenotypes; cancer stem cells; polyploidal giant cancer cells; therapy-induced senescence/dormancy

(This special issue belongs to the Section Molecular Cancer Biology)

Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention

edited by Adam Barsouk

submission deadline 31 Jul 2025 | Viewed by 29 | Submission Open

Keywords: epidemiology; disparities; oncology; cancer; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Innovation, New Technologies, and Future Prospects in Endometrial Cancer Surgery

edited by

Donatella Caserta

submission deadline 31 Jul 2025 | Viewed by 28 | Submission Open

Keywords: endometrial cancer surgery; robotic surgery; minimally invasive procedures; image-guided surgery; artificial intelligence; surgical innovations; patient outcomes; surgical precision; future prospects; fertility sparing

(This special issue belongs to the Section Clinical Research of Cancer)

Computational Research in Cancer Neuroscience

edited by Shaolei Teng

submission deadline 31 Jul 2025 | Viewed by 23 | Submission Open

Keywords: machine learning; large language models; protein structure modeling; omics data analysis; neural– cancer communication; tumor microenvironments; personalized medicine; targeted therapies; cancer neuroscience

(This special issue belongs to the Section Methods and Technologies Development)

Palliative and Supportive Care in Cancers

edited by Ahmed Elsayem

submission deadline 31 Jul 2025 | Viewed by 20 | Submission Open

Keywords: palliative care; symptom distress; oncology; emergency medicine; critical care; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Significance of CAR T-Cell Therapy in Aggressive B-Cell Lymphoma Treatment

edited by

Wingkeung Chan

submission deadline 31 Jul 2025 | Viewed by 20 | Submission Open

Keywords: CAR-T therapy; non-hodgkin lymphoma; hodgkin lymphoma; CAR-T persistence; immune-related adverse events (irAEs); resistance mechanisms; combination therapy; tumor microenvironment; multiomics data analysis

(This special issue belongs to the Section Cancer Therapy)

Development of Biomarkers and Antineoplastic Drugs in Solid Tumors

edited by

Rosa Falcone

, Sofia Verkhovskaia and Michela Roberto

submission deadline 31 Jul 2025 | Viewed by 19 | Submission Open

Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence

(This special issue belongs to the Section Cancer Drug Development)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 31 Jul 2025 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research of Cancer)

Novel Therapies in Metastatic Castration-Resistant Prostate Cancer

edited by Kathryn E. Meier

submission deadline 1 Aug 2025 | 1 articles | Viewed by 1643 | Submission Open

Keywords: signal transduction inhibitors; targeted therapies; immunotherapy; radiopharmaceuticals; PARP inhibitors; biomarker-based approaches

(This special issue belongs to the Section Cancer Therapy)

BRCA Associated Cancers: Latest Predictive and Therapeutic Approaches

edited by Melpomeni Kalofonou

submission deadline 1 Aug 2025 | Viewed by 250 | Submission Open

Keywords: BRCA; ovarian cancer; breast cancer; prostate cancer; pancreatic cancer; genetics; epigenetics

(This special issue belongs to the Section Cancer Therapy)

High-Quality Cancer Care in Older Adults

edited by

Fabio Monzani

and

Valeria Calsolaro

submission deadline 1 Aug 2025 | Viewed by 30 | Submission Open

Keywords: elderly; target therapy; cancer treatment; cancer care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Inflammation, Immunity, and Cancer Progression: 2nd Edition

edited by

Deepak Parashar

Vivek K. Kashyap

and

Subhash Tripathi

submission deadline 1 Aug 2025 | Viewed by 26 | Submission Open

Keywords: inflammation; cancer immunity; transcriptomics; epigenomics; immunometabolism; pharmacogenomic; bioinformatics data; immunopharmacogenomics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advancements in Lung Cancer Surgical Treatment and Prognosis

edited by Sai Yendamuri and

Kenneth Patrick Seastedt

submission deadline 15 Aug 2025 | 7 articles | Viewed by 7191 | Submission Open

Keywords: lung cancer; surgical techniques; targeted therapies; immunotherapies; accurate staging; biomarker detection; clinical trials; multimodality therapy; artificial intelligence (AI) in thoracic oncology; enhanced recovery after thoracic surgery (ERATS)

(This special issue belongs to the Section Cancer Therapy)

Advances in Esophageal Cancer

edited by Sacheen Kumar

submission deadline 15 Aug 2025 | Viewed by 43 | Submission Open

Keywords: esophageal adenocarcinoma; esophageal squamous cell carcinoma; long-term survival; biomarkers; disease surveillance; treatment response

(This special issue belongs to the Section Cancer Therapy)

Antioxidants in Cancers

edited by Asif Raza

submission deadline 15 Aug 2025 | Submission Open

Keywords: antioxidants in cancer; oxidative stress and cancer; tumor microenvironment; cancer prevention strategies; therapy resistance and antioxidants; reactive oxygen species (ROS); natural antioxidants; synthetic antioxidants; precision oncology; chemoprevention

(This special issue belongs to the Section Cancer Therapy)

Immunotherapy of Glioblastoma

edited by

Mao Li

submission deadline 16 Aug 2025 | Viewed by 34 | Submission Open

Keywords: glioblastoma; immunotherapy; antigen presentation; CNS lymphatic system; adoptive cell therapy; cancer vaccine; checkpoint blockage

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Neoadjuvant Therapy for Urologic Cancer

edited by Carlo Messina

submission deadline 17 Aug 2025 | Viewed by 65 | Submission Open

Keywords: neoadjuvant treatment; bladder cancer; prostate cancer; renal cell carcinoma; penile cancers; immunotherapy; antibody– drug conjugates

(This special issue belongs to the Section Cancer Therapy)

Exploring Non-coding RNA Signatures in Cancer: Definitions and Implications for Diagnosis and Therapy

edited by

Amog Urs

and Udhayakumar Gopal

submission deadline 20 Aug 2025 | Viewed by 130 | Submission Open

Keywords: non-coding RNA; biomarkers; gene regulation; microRNA; long non-coding RNA; circular RNA; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Clinical Advances and State-of-Art Management in Genitourinary Cancers

edited by

Jad Chahoud

and Adnan Fazili

submission deadline 25 Aug 2025 | Viewed by 85 | Submission Open

Keywords: genitourinary malignancies; tumor– immune microenvironment (TIME); tumor biology; genomic characterization; targeted drug therapy; immunotherapy

(This special issue belongs to the Section Clinical Research of Cancer)

Modern Approach to Oral Cancer

edited by

Maria Maddalena Marrapodi

and Giuseppe Minervini

submission deadline 30 Aug 2025 | 8 articles | Viewed by 11610 | Submission Open

Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health

(This special issue belongs to the Section Cancer Therapy)

Advances in Lung Ultrasound in Cancer Patients

edited by Helmut Prosch and

Ehsan Safai Zadeh

submission deadline 30 Aug 2025 | Viewed by 88 | Submission Open

Keywords: lung ultrasound; neoplastic pleuro-pulmonary lesions; lung cancer; oncologic imaging; ultrasound; CEUS; elastography

(This special issue belongs to the Section Methods and Technologies Development)

Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies

edited by

Heba Khella

submission deadline 30 Aug 2025 | Viewed by 40 | Submission Open

Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 951-1000 on page 20 of 22.

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