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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances on Imaging and Treatment of Head and Neck Cancer

edited by Yading Yuan, Vishruta A. Dumane,

Haibo Lin

and Luqman Dad

submission deadline 31 Mar 2026 | Viewed by 331 | Submission Open

Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning

(This special issue belongs to the Section Cancer Therapy)

Significance of KRAS Gene Mutations in Colorectal Cancer (2nd Edition)

edited by

Grazia Palomba

and

Maria Cristina Sini

submission deadline 31 Mar 2026 | Viewed by 145 | Submission Open

Keywords: KRAS; colorectal cancer; target therapy; mechanism; treatment targets

(This special issue belongs to the Section Molecular Cancer Biology)

Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition)

edited by

Mark Jesus M. Magbanua

and

Wen Li

submission deadline 31 Mar 2026 | Viewed by 79 | Submission Open

Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)

edited by

Ioannis Mitroulis

, Konstantinos Liapis and

Eleni Gavriilaki

submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open

Keywords: myelodysplastic syndrome; acute myeloid leukemia; bone marrow micro-environment; targeted therapies; hematopoietic stem cell; leukemic stem cell; hematopoietic stem cell transplantation

(This special issue belongs to the Section Cancer Therapy)

Immune Landscape of Multiple Myeloma

edited by Muhamed Baljevic and

Shebli Atrash

submission deadline 31 Mar 2026 | Viewed by 70 | Submission Open

Keywords: myeloma; immune; T cells; therapy; fitness

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Genetic Alterations and the Tumor Microenvironment

edited by Shanye Yin

submission deadline 31 Mar 2026 | Viewed by 69 | Submission Open

Keywords: tumor microenvironment; cancer immunology; immune checkpoint blockade; somatic mutations; T cell signaling; immune evasion; macrophage polarization; cancer immunotherapy resistance; single-cell transcriptomics; spatial analysis

(This special issue belongs to the Section Tumor Microenvironment)

Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer

edited by

Marta Lukaszewicz-Zajac

and

Adrianna Romanowicz

submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open

Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Colorectal Cancer Liver Metastases

edited by

Piero Boraschi

and

Francescamaria Donati

submission deadline 31 Mar 2026 | Viewed by 65 | Submission Open

Keywords: liver metastases; colorectal cancer; treatment; imaging; oncologic strategy

(This special issue belongs to the Section Cancer Metastasis)

Proteomics in Skin Cancer: Recent Advances

edited by

Ali Azimi

and Beatrice Dyring-Andersen

submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open

Keywords: proteomics; skin cancer; mass spectrometry; melanoma; non-melanoma skin cancers; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Mitochondrial Metabolism in Cancer Immune Responses

edited by

Jae Ho Seo

and Kiwon Lee

submission deadline 31 Mar 2026 | Viewed by 62 | Submission Open

Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Screening and Surveillance of Gastrointestinal and Pancreatic Cancers

edited by Darina Kohoutová and

Jan Bures

submission deadline 31 Mar 2026 | Viewed by 59 | Submission Open

Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Novel Strategies to Fight Metastatic Breast Cancer

edited by

Fernando Schmitt

and

Nuno Vale

submission deadline 31 Mar 2026 | Viewed by 55 | Submission Open

Keywords: breast cancer; metastasis; targeted therapy; biomarkers; personalized medicine; prognosis

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Quantitative Imaging, AI, and Novel Imaging Techniques for Precision Radiology in Prostate Cancer

edited by Rulon R. Mayer,

Charles Simone

and

Yuan Yuan

submission deadline 31 Mar 2026 | Viewed by 52 | Submission Open

Keywords: prostate cancer; multi-parametric MRI (mpMRI); bi-parametric MRI; positron emission tomography (PET); computed tomography (CT); ultrasound (US); artificial intelligence (AI); convolutional neural network; visual language model; computer-aided diagnosis; spatially registered multi-parametric MRI; prostate specific membrane antigen in PET/CT

(This special issue belongs to the Section Methods and Technologies Development)

The Development of Immunotherapies to Treat Lymphoma

edited by

Christina Kalpadakis

submission deadline 31 Mar 2026 | Viewed by 47 | Submission Open

Keywords: lymphoma immunotherapy; CAR T-cell therapy; immune checkpoint inhibitors; monoclonal antibodies; personalized immunotherapy

Clinical and Surgical Outcomes in the Management of Extremity Soft Tissue Sarcomas (2nd Edition)

edited by

Matthew T. Houdek

submission deadline 31 Mar 2026 | Viewed by 44 | Submission Open

Keywords: soft tissue sarcoma; outcome; limb salvage; radiotherapy; surgery

(This special issue belongs to the Section Cancer Therapy)

Lipids and Small Metabolites in Cancer—2nd Edition

edited by

Zsolt Balogi

and

Laszlo Vigh

submission deadline 31 Mar 2026 | Viewed by 42 | Submission Open

Keywords: lipid; small metabolites; cancer; metabolome- and lipidome-related mechanisms; amino acids; fatty acids; numerous components of biochemical pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Drug Discovery and Development: 2nd Edition

edited by Gary Piazza

submission deadline 31 Mar 2026 | Viewed by 42 | Submission Open

Keywords: signal transduction inhibitors; small-molecule inhibitors; antibodies; PROTOC; immunotherapy; medicinal chemistry; chemical optimization; high-throughput screening

(This special issue belongs to the Section Cancer Drug Development)

Robotic and Thoracoscopic Surgery for Thoracic Oncology

edited by

Elisa Meacci

submission deadline 31 Mar 2026 | Viewed by 39 | Submission Open

Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology

(This special issue belongs to the Section Clinical Research of Cancer)

Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms

edited by

Takahiro Nakajima

submission deadline 31 Mar 2026 | Viewed by 28 | Submission Open

Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing

(This special issue belongs to the Section Cancer Therapy)

Real-World Clinical Studies in Acute Leukemia

edited by

Anna Candoni

submission deadline 31 Mar 2026 | Viewed by 27 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoid leukemia (ALL); refractory/relapsed leukemia; target therapy; FLT3 inhibitors; IDH (1-2) inhibitors; venetoclax; hypomethylating agents; stem cell transplantation (SCT); minimal residual disease (MRD); MRD-driven therapy

(This special issue belongs to the Section Clinical Research of Cancer)

Gene Fusions in Cancer

edited by Christopher R. McEvoy and

Ing Soo Tiong

submission deadline 31 Mar 2026 | Viewed by 17 | Submission Open

Keywords: gene fusions; targeted therapy; cancer diagnostics; molecular pathology

(This special issue belongs to the Section Molecular Cancer Biology)

Deep Learning and Radiomics for Cancer Diagnosis, Staging, and Treatment Response

edited by Mohamed Shehata,

Mostafa Elhosseini

Mahmoud Badawy

and Hanaa ZainEldin

submission deadline 31 Mar 2026 | Viewed by 12 | Submission Open

Keywords: radiomics; deep learning; cancer imaging; diagnosis; staging; treatment response; machine learning; medical image analysis; precision oncology; federated learning; AI in healthcare

(This special issue belongs to the Section Methods and Technologies Development)

Flow Cytometry and Beyond: Innovative Cytometric Approaches in Cancer Detection, Profiling, and Therapeutic Monitoring

edited by

George Vartholomatos

Georgios Markopoulos

, Lefkothea Dova and Savvas Dimitriadis

submission deadline 31 Mar 2026 | Viewed by 12 | Submission Open

Keywords: cancer diagnostics; next-generation flow cytometry; AI-driven cytometry; high-dimensional single-cell analysis; cancer immunophenotyping; cytometry-based biomarkers; tumor heterogeneity; extracellular vesicles; spectral and mass cytometry; intraoperative flow cytometry

(This special issue belongs to the Section Methods and Technologies Development)

Modern Approaches in Gastrointestinal (GI) Oncology: From Bench to Bedside

edited by

Francesco Fiorica

submission deadline 31 Mar 2026 | Viewed by 7 | Submission Open

Keywords: gastrointestinal oncology; radiotherapy and immunotherapy; translational cancer research; radiogenomics and AI; biomarkers and personalized treatment

(This special issue belongs to the Section Cancer Therapy)

TGF-β Signaling in the Tumor Microenvironment: Dual Roles in Cancer Progression and Therapy

edited by

Byung-Gyu Kim

submission deadline 31 Mar 2026 | Viewed by 2 | Submission Open

Keywords: TGF-β signaling; tumor microenvironment; solid tumors; hematologic malignancies; immune modulation; therapeutic resistance; TGF-β pathway inhibitors; cancer immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Rare Tumors in Children: Trends in Diagnosis, Treatment and Prevention (2nd Edition)

edited by

Antonio Ruggiero

and

Stefano Mastrangelo

submission deadline 1 Apr 2026 | 3 articles | Viewed by 3887 | Submission Open

Keywords: pediatric oncology; pediatric drugs; clinical pharmacology

(This special issue belongs to the Section Pediatric Oncology)

Advances in Neuro-Oncological Imaging (Volume II)

edited by

Julia Furtner

and

Anna Sophie Berghoff

submission deadline 1 Apr 2026 | 2 articles | Viewed by 2914 | Submission Open

Keywords: central nervous system (CNS) tumors; brain tumors; spinal cord tumors; magnetic resonance imaging (MRI); positron emission tomography (PET); intraoperative MRI; imaging biomarkers; metabolic imaging; radiomics; machine learning

(This special issue belongs to the Section Methods and Technologies Development)

Current Progress and Research Trends in Ocular Oncology—2nd Edition

edited by Utta Berchner-Pfannschmidt,

Miltiadis Fiorentzis

and Nikolaos E. Bechrakis

submission deadline 1 Apr 2026 | Viewed by 61 | Submission Open

Keywords: ocular oncology; uveal melanoma; conjunctival melanoma; retinoblastoma; primary tumor; recurrence; metastasis; oncogenic pathways; genetic and cellular heterogeneity; cancer immunity; diagnostic strategies; therapeutic options

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Robot-Assisted Radical Prostatectomy for Prostate Cancer

edited by Arnulf Stenzl

submission deadline 1 Apr 2026 | Viewed by 58 | Submission Open

Keywords: robotic surgery; machine learning; comparative study; ergonomics; cost; patient reported outcome

(This special issue belongs to the Section Methods and Technologies Development)

Cancer Cell Motility (2nd Edition)

edited by

Gianluca Aguiari

and

Nicoletta Bianchi

submission deadline 2 Apr 2026 | Viewed by 47 | Submission Open

Keywords: cancer; EMT; invasion; metastasis; p53-related signaling; apoptosis; autophagy; cell cycle; anticancer drugs

(This special issue belongs to the Section Tumor Microenvironment)

The Exercise Therapy in Cancers and Hematological Disease Rehabilitation

edited by

Anna Lubkowska

submission deadline 3 Apr 2026 | Viewed by 42 | Submission Open

Keywords: cancer rehabilitation interventions; multidisciplinary care; oncology exercise; cancer-related fatigue (CRF); cancer care rehabilitation plan; hematological malignancies; hematological disease; rehabilitation; exercise therapy; physical activity

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

The Role of Regulatory Non-Coding RNA in Cancer (2nd Edition)

edited by

Jyoti Srivastava

and

Sanjay Premi

submission deadline 4 Apr 2026 | Viewed by 8 | Submission Open

Keywords: cancer initiation; cancer progression; metastasis; ncRNAs; miRNAs; lncRNAs; gene regulation; chromatin remodeling; targeted therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Cancers in Dermatology—from Diagnosis to Treatment

edited by

Agnieszka Żebrowska

submission deadline 8 Apr 2026 | Viewed by 43 | Submission Open

Keywords: dermato-oncology ; skin cancer immunotherapy ; cutaneous lymphoma ; molecular diagnostics ; multidisciplinary oncology care

(This special issue belongs to the Section Cancer Pathophysiology)

Neurosurgery Research on Brain Tumors

edited by Toshihide Tanaka

submission deadline 10 Apr 2026 | Viewed by 38 | Submission Open

Keywords: neuro-oncology; neurosurgical technique; brain tumors; neuroimages

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Oncology: State-of-the-Art Research in Austria

edited by

Bahil Ghanim

and

Mir Alireza Hoda

submission deadline 15 Apr 2026 | 2 articles | Viewed by 6379 | Submission Open

Keywords: oncology; cancer; research; tumor; Austria

(This special issue belongs to the Section Cancer Therapy)

Detection of Breast Cancer with Mammography

edited by

Luca Nicosia

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1340 | Submission Open

Keywords: mammography; breast cancer detection; imaging technologies; artificial intelligence; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Recent Advances in Radiological Imaging for Head and Neck Squamous Cell Carcinoma

edited by Mintu Nath and

Fergus McKiddie

submission deadline 15 Apr 2026 | Viewed by 232 | Submission Open

Keywords: head and neck squamous cell carcinoma; computed tomography (CT); positron emission tomography (PET); PET-CT; radiological imaging; image processing; image segmentation; diagnosis; treatment modalities; prediction and prognostic models; mathematical and statistical models; machine learning and deep learning techniques

(This special issue belongs to the Section Methods and Technologies Development)

Advanced Insights into the Etiology of Lymphoma

edited by Susan L. Slager and James R. Cerhan

submission deadline 15 Apr 2026 | Viewed by 134 | Submission Open

Keywords: lymphoma etiology; genetic predisposition; clonal hematopoiesis; precursor conditions; risk stratification; viral oncogenesis; non-Hodgkin lymphoma; Hodgkin lymphoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Cellular Heterogeneity and Plasticity in the Tumor Microenvironment

edited by

Loredana Albonici

and

Manuel Scimeca

submission deadline 15 Apr 2026 | Viewed by 50 | Submission Open

Keywords: tumor microenvironment (TME); tumor microenvironmental heterogeneity and drug resistance; cancer cell plasticity and immune evasion; epithelial– mesenchymal transition (EMT); tumor immune context

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Radiation Therapy for Brain Metastases

edited by Luis A. Pérez-Romasanta

submission deadline 15 Apr 2026 | Viewed by 19 | Submission Open

Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography

(This special issue belongs to the Section Cancer Therapy)

State-of-the-Art Surgical Treatment for Lung Cancers

edited by

Andrea Axtell

and

Malcolm DeCamp

submission deadline 15 Apr 2026 | Viewed by 17 | Submission Open

Keywords: lung cancer; lung cancer surgery; sublobar resection; segmentectomy; minimally invasive surgery; robotic surgery; tumor localization; mediastinal staging

(This special issue belongs to the Section Cancer Therapy)

Clinical and Molecular Biomarkers in Breast Cancer Management

edited by Zahi I. Mitri

submission deadline 15 Apr 2026 | Submission Open

Keywords: prognostic biomarkers; predictive biomarkers; molecular assays; therapeutics; special situations in breast cancer

(This special issue belongs to the Section Cancer Biomarkers)

Prostate Cancer: Molecular Imaging and Magnetic Resonance Imaging (MRI)

edited by Marco Paciotti and Davide Maffei

submission deadline 17 Apr 2026 | 2 articles | Viewed by 3374 | Submission Open

Keywords: prostate cancer; prostate imaging; diagnosis; clinical staging; magnetic resonance imaging (MRI); fusion biopsy; molecular imaging; positron emission tomography (PET); PSMA PET/CT; PSMA-based therapy

(This special issue belongs to the Section Methods and Technologies Development)

Unique Perspectives in Cancer Signaling (2nd Edition)

edited by

Peiwen Fei

submission deadline 18 Apr 2026 | Viewed by 62 | Submission Open

Keywords: oncogenesis; cancer signaling; technology; translational; clinical; epidemiology

(This special issue belongs to the Section Cancer Therapy)

Advancements in Child, Adolescent, and Young Adult Cancer Survivorship

edited by

Juan A. Ortega-García

submission deadline 20 Apr 2026 | 4 articles | Viewed by 5663 | Submission Open

Keywords: late effects; chronic diseases; prevention; rehabilitation; remediation; psychosocial factors; quality of life; lifestyles; surveillance; survivors; educational strategies

(This special issue belongs to the Section Pediatric Oncology)

Research on Current Progress in Penile Cancer

edited by Juan J. Chipollini and Ahmet Murat Aydin

submission deadline 25 Apr 2026 | 4 articles | Viewed by 7952 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Clinical Applications of Integrative Analysis of Validated Somatic and Germline Genomic Results in Oncology

edited by

Arezou A. Ghazani

submission deadline 25 Apr 2026 | 1 articles | Viewed by 3232 | Submission Open

Keywords: tumor and constitutional genome integration; clinical application of somatic and germline findings; precision oncology

(This special issue belongs to the Section Molecular Cancer Biology)

PD-1/PD-L1 Immune Checkpoint Therapy: From Predictive Biomarkers to Noninvasive Imaging 2nd Edition

edited by

Patrizia Ferroni

Fiorella Guadagni

and

Mario Roselli

submission deadline 25 Apr 2026 | Viewed by 276 | Submission Open

Keywords: PD-1; PD-L1; anti-cancer immune response; immune checkpoint; immunotherapy; biomarker; immuno-PET radiotracers; drug combinations

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Surgical Treatment of Hepato-Pancreato-Biliary Cancers

edited by Mariano C. Giglio

submission deadline 27 Apr 2026 | 1 articles | Viewed by 49 | Submission Open

Keywords: pancreatic cancer; hepatocellular carcinoma; colorectal liver metastases; liver surgery; pancreatic surgery; hepato-biliary cancers

(This special issue belongs to the Section Cancer Therapy)

Immune Biomarkers in Solid Tumors: From Peripheral Blood Parameters to Tissue-Based Indicators for Prognosis and Therapy Response

edited by

Ioannis P. Trontzas

and

Konstantinos Syrigos

submission deadline 28 Apr 2026 | Viewed by 48 | Submission Open

Keywords: immune biomarkers; solid tumors; peripheral blood immune parameters; circulating immune cells; cytokines; tissue-based biomarkers; immune checkpoint molecules; prognostic biomarkers; predictive biomarkers; tumor microenvironment; immunotherapy response; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Displaying special issue 951-1000 on page 20 of 23.

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