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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Precision Diagnostics and Therapeutic Innovation in Brain Tumors

edited by

Anudeep Yekula

submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open

Keywords: brain tumors; neuro-oncology; precision oncology; molecular diagnostics; methylation profiling; liquid biopsy; radiomics; targeted therapy; immunotherapy; clinical trials

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Novel Pharmacotherapeutic Strategies for Neuroendocrine Tumors: Drug Repurposing, Combinations, and Beyond

edited by Qiyun Tang and Mujie Ye

submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open

Keywords: neuroendocrine tumors; tumor metabolism; immune microenvironment; immunotherapy; targeted therapy (including PRRT); metabolic reprogramming; basic research/translational research; therapeutic resistance; biomarkers

(This special issue belongs to the Section Cancer Drug Development)

Artificial Intelligence in Cancers: Enhancing Diagnosis and Treatment

edited by

Rong Wang

, Adam Shephard and Shan E Ahmed Raza

submission deadline 28 Feb 2027 | Viewed by 46 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; precision oncology; cancer diagnosis; cancer screening; treatment planning; prognostic prediction; digital pathology; medical imaging; radiomics; genomics; multiomics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Boron Neutron Capture Therapy (BNCT) for Solid Cancers: (2) Current Advances and Future Perspectives in Clinical Practice

edited by

Yasuaki Ichikawa

and

Tadashi Hanafusa

submission deadline 28 Feb 2027 | Viewed by 35 | Submission Open

Keywords: refractory cancer; boron neutron capture therapy; targeted therapy; good patient QOL; clinical practice

(This special issue belongs to the Section Methods and Technologies Development)

Boron Neutron Capture Therapy (BNCT) for Solid Cancers: (1) Preclinical Innovations and Biological Mechanisms

edited by

Yasuaki Ichikawa

and

Tadashi Hanafusa

submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open

Keywords: boron neutron capture therapy (BNCT); refractory cancer; targeted therapy; good patient QOL; preclinical research

(This special issue belongs to the Section Methods and Technologies Development)

Progress and Perspectives of Organoid Technology in Precision Oncology

edited by Leli Zeng

submission deadline 28 Feb 2027 | Viewed by 25 | Submission Open

Keywords: organoids; precision oncology; patient-derived tumor models; drug screening; tumor microenvironment; treatment resistance; multi-omics; translational cancer research

(This special issue belongs to the Section Clinical Research in Cancer)

Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies

edited by

Matin Sheriff

and Eleni D. Kapsali

submission deadline 28 Feb 2027 | Viewed by 21 | Submission Open

Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine

(This special issue belongs to the Section Tumor Microenvironment)

Feature Papers in Section “Methods and Technologies Development” in 2026

edited by

Maxim V. Berezovski

submission deadline 1 Mar 2027 | 3 articles | Viewed by 3199 | Submission Open

Keywords: artificial intelligence (AI); medical imaging; clinical diagnostics; oncology biomarkers; precision medicine; big data integration; early cancer detection; radiomics; therapy response prediction; translational technology

(This special issue belongs to the Section Methods and Technologies Development)

Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

edited by

Lubna Khaldi

and

Nektarios Koufopoulos

submission deadline 1 Mar 2027 | 1 articles | Viewed by 1365 | Submission Open

Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Endoscopic Management of Esophageal Cancer

edited by Hugo Uchima and

Cristina Bugés Sánchez

submission deadline 1 Mar 2027 | 1 articles | Viewed by 945 | Submission Open

Keywords: endoscopic submucosal dissection (ESD); esophageal squamous cell carcinoma; Barrett’s esophagus

(This special issue belongs to the Section Cancer Therapy)

Precise and Personalized Radiation Therapy for Cancer Treatment

edited by Thomas Weissmann and

Michael Goldstein

submission deadline 1 Mar 2027 | Viewed by 272 | Submission Open

Keywords: radiation research; artificial intelligence; cancer; adaptive radiotherapy; stereotactic radiotherapy; radiotherapy; (radio)-immunotherapy; (radio)-chemotherapy; precision radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies

edited by Nithya Ratnavelu and Ioannis Biliatis

submission deadline 5 Mar 2027 | 5 articles | Viewed by 19754 | Submission Open

Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Symptom Management in Cancer Care

edited by Lena Lee and Joosun Shin

submission deadline 5 Mar 2027 | Viewed by 387 | Submission Open

Keywords: symptom burden; symptom management; health service; palliative care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions

edited by

Apriliana Kartikasari

submission deadline 10 Mar 2027 | 1 articles | Viewed by 3359 | Submission Open

Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Molecular Pathogenesis of Lung Cancer: From Oncogenic Drivers to Tumor Microenvironment

edited by

Bin Xu

submission deadline 12 Mar 2027 | Viewed by 302 | Submission Open

Keywords: lung cancer; oncogenic drivers; tumor microenvironment; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers

(This special issue belongs to the Section Cancer Pathophysiology)

Extracellular Vesicles in Cancer: Biology, Biomarkers and Therapeutic Applications

edited by

Nathan Wall

submission deadline 12 Mar 2027 | Viewed by 9 | Submission Open

Keywords: extracellular vesicles; exosomes; biomarker; liquid biopsy; tumor microenvironment

Clinical, Immune, and Microbial Markers of Response to Systemic Therapy in Skin Cancer

edited by

Robin Reschke

submission deadline 14 Mar 2027 | 1 articles | Viewed by 600 | Submission Open

Keywords: melanoma; cutaneous squamous cell carcinoma; immunotherapy; immune checkpoint inhibitors; tumor microenvironment; microbiome; predictive biomarkers

Contemporary Management of Urologic Cancers

edited by

Ruben Blachman-Braun

and Hangcheng Fu

submission deadline 14 Mar 2027 | Viewed by 90 | Submission Open

Keywords: urologic oncology; prostate cancer; kidney cancer; bladder cancer; testicular cancer; penile cancer; upper urinary tract cancer; focal therapy; cancer survivorship; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Proton Therapy of Cancer Treatment

edited by Minglei Kang, Benjamin Durkee and Kuo Men

submission deadline 15 Mar 2027 | 5 articles | Viewed by 9228 | Submission Open

Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning

(This special issue belongs to the Section Cancer Therapy)

Resistance in Lung Cancer

edited by Mohamed Gadelkarim

submission deadline 15 Mar 2027 | Viewed by 612 | Submission Open

Keywords: lung cancer; SCLC; NSCLC; drug resistance; genetic mutations; tumor microenvironment; EMT; biomarkers; targeted therapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

The Critical Intersection of Tobacco Use and Cancer Care

edited by Irene Tamí-Maury

submission deadline 15 Mar 2027 | Viewed by 391 | Submission Open

Keywords: cancer; oncology settings; smoking; tobacco use; prevention; cessation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Robotic and Laparoscopic Techniques for Urologic Cancers: Innovations in Resection and Reconstruction

edited by

Tobias Klatte

submission deadline 15 Mar 2027 | Viewed by 310 | Submission Open

Keywords: robot-assisted surgery; surgical robotics; minimally invasive surgery; artificial intelligence; complications; prognostic and predictive factors; planning; perioperative care

(This special issue belongs to the Section Methods and Technologies Development)

Integrative Cancer Genomics: From Classical Cytogenetics to Emerging Molecular Technologies

edited by Ying S. Zou

submission deadline 15 Mar 2027 | Viewed by 200 | Submission Open

Keywords: integrative cancer genomics; cancer cytogenetics; molecular cytogenetics; chromosomal abnormalities; optical genome mapping; next-generation sequencing; nanopore sequencing; 3D/Hi-C technologies; structural variants; AI in cytogenetics; hematological malignancies; FISH; chromosomal microarray; solid tumors

(This special issue belongs to the Section Methods and Technologies Development)

Mesothelioma Environmental Risk Factors and Epidemiological and Biological Insights

edited by Sonja Klebe

submission deadline 20 Mar 2027 | 1 articles | Viewed by 1244 | Submission Open

Keywords: mesothelioma; asbestos; mesothelial proliferation; therapy; marker

Inflammatory Bowel Disease and Cancers: What Connections Lie Between Them?

edited by

Ferdinando D'Amico

submission deadline 20 Mar 2027 | Viewed by 177 | Submission Open

Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; cancers

From Bench to Bedside: Systemic Therapy in Renal Cell Carcinoma

edited by Hailiang Zhang

submission deadline 20 Mar 2027 | Viewed by 6 | Submission Open

Keywords: renal cell carcinoma; systemic therapy; immune checkpoint inhibitors; targeted therapy; tumor microenvironment; biomarkers; precision oncology; translational research

(This special issue belongs to the Section Cancer Therapy)

Image Assisted High Precision Radiation Oncology

edited by Christopher Njeh and

Senthamizhchelvan Srinivasan

submission deadline 25 Mar 2027 | 4 articles | Viewed by 3806 | Submission Open

Keywords: image-guided radiation therapy (IGRT); MR-guided radiation therapy (MRgRT); adaptive radiation therapy (ART); radiomics and AI in imaging; multi-modal imaging (CT, MRI, PET); treatment planning and verification; real-time tracking and motion management; stereotactic radiotherapy (SBRT/SRS); imaging biomarkers; dose accumulation and image registration

(This special issue belongs to the Section Methods and Technologies Development)

Feature Papers in Section “Infectious Agents and Cancer”

edited by

Massimiliano Berretta

submission deadline 25 Mar 2027 | 1 articles | Viewed by 939 | Submission Open

Keywords: infectious agents; microbiota; biomarker; oncology; cancers

(This special issue belongs to the Section Infectious Agents and Cancer)

Imaging-Based Cancer Radiotherapy

edited by

Fariba Tohidinezhad

and Alberto Traverso

submission deadline 25 Mar 2027 | 1 articles | Viewed by 675 | Submission Open

Keywords: radiotherapy; imaging biomarkers; artificial intelligence; radiomics; toxicity prediction; adaptive radiotherapy; automated treatment planning; image-guided radiotherapy; multimodal learning; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Genome Instability, Ubiquitin Signaling and Cancer Therapy

edited by

Sehbanul Islam

and Aftab Alam

submission deadline 30 Mar 2027 | Viewed by 257 | Submission Open

Keywords: DNA damage response; DNA repair; replication stress; ubiquitin–proteasome system; E3 ubiquitin ligases; targeted protein degradation; cell cycle checkpoints; drug resistance

Reproductive and Hormonal Factors in Breast and Gynecological Cancers: Epidemiological, Pathological, Diagnostic, and Therapeutic Perspectives

edited by

Raluca Anca Balan

submission deadline 30 Mar 2027 | Viewed by 221 | Submission Open

Keywords: breast cancer; gynecological cancers; reproductive factors; hormonal exposure; epidemiology; tumor pathology; molecular subtypes; biomarkers; early diagnosis; risk stratification; endocrine therapy; targeted therapy; treatment resistance; personalized medicine

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Ovarian Cancer Research and Treatment: 2nd Edition

edited by

Maria Barbolina

submission deadline 31 Mar 2027 | 8 articles | Viewed by 14442 | Submission Open

Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets

(This special issue belongs to the Section Cancer Therapy)

Clinical Treatment and Prognosis of Breast Cancer

edited by Roxana Popescu and

Ionut Marcel Cobec

submission deadline 31 Mar 2027 | 4 articles | Viewed by 12010 | Submission Open

Keywords: breast cancer; targeted therapy; personalized therapy; alternative approach; tumor biology; gynecologic oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Urological Cancer: Epidemiology and Genetics

edited by Ilir Agalliu and Evan Kovac

submission deadline 31 Mar 2027 | 3 articles | Viewed by 6742 | Submission Open

Keywords: environmental factors; lifestyle; genetic susceptibility; biomarkers; prostate cancer; bladder cancer; kidney cancer

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Hybrid Molecular Imaging Approaches in Cancer: PET/CT, PET/MRI, and Beyond

edited by

Luca Urso

submission deadline 31 Mar 2027 | 3 articles | Viewed by 3572 | Submission Open

Keywords: PET/CT; PET/MRI; hybrid molecular imaging; radiomics and artificial intelligence; conventional PET Radiotracers; emerging PET Radiotracers; cancer imaging

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Flow Cytometry in Hematologic Malignancies

edited by

Kristy Wolniak

and Lucy Fu

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2681 | Submission Open

Keywords: flow cytometry; hematology; oncology; malignancy; lymphoma; leukemia; pathology; innovation; methodology; diagnosis

(This special issue belongs to the Section Methods and Technologies Development)

Pancreatic Neoplasms in the 21st Century: Challenges and Opportunities in Diagnosis and Management

edited by

Beata Jabłońska

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2511 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDCA); pancreatic mucinous cystic neoplasm (MCN); pancreatic intraductal papillary mucinous neoplasm (IPMN); pancreatic serous cystic neoplasm (SCN); pancreatic solid pseudopapillary neoplasm (SPN); pancreatic neuroendocrine tumor (PNET); pancreatectomy; pancreatic resection

Innovations in Colorectal Cancer

edited by Sandy Hwang Fang

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1972 | Submission Open

Keywords: colon cancer; rectal cancer; innovation; clinical trials; total neoadjuvant therapy; medical oncology; radiation oncology

Modulating the Acidic Tumor Microenvironment to Enhance the Efficacy and Reduce the Toxicity of Cancer Treatment

edited by Hiromi Wada, Keisuke Shirai and

Dario Marchetti

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1632 | Submission Open

Keywords: Alkalization therapy; tumor microenvironment; Warburg effect; pH gradient; mitochondrial metabolism; redox balance; immune modulation; dissipative structure; personalized oncology; thermodynamic homeostasis

(This special issue belongs to the Section Tumor Microenvironment)

Fertility and Pregnancy in Cancer

edited by

Bettina Böttcher

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1253 | Submission Open

Keywords: cancer; gonadotoxic treatment; pregnancy; offspring; long term survivorship; fertility preservation

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Surgical Strategies in Neuro-Oncology: Optimizing Outcomes for Brain and Spinal Tumors

edited by

Ramazan Jabbarli

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1037 | Submission Open

Keywords: neuro-oncology; brain tumors; glioma; glioblastoma; brain metastases; spinal tumors; spinal metastases; neurosurgery; surgical strategy; outcome research

(This special issue belongs to the Section Cancer Therapy)

Current Advances in Surgical and Systemic Treatment of Breast Cancer

edited by

Kwok-Leung Cheung

and

Srinivasan Madhusudan

submission deadline 31 Mar 2027 | 1 articles | Viewed by 954 | Submission Open

Keywords: breast cancer; breast surgery; oncoplastic surgery; systemic therapy; biomarkers; targeted therapy

(This special issue belongs to the Section Clinical Research in Cancer)

Molecular Mechanisms of Resistance to Cancer Therapies

edited by

Amancio Carnero

and

Rikki A.M. Brown

submission deadline 31 Mar 2027 | Viewed by 576 | Submission Open

Keywords: therapy resistance; cancer heterogeneity; drug resistance mechanisms; targeted therapy resistance; immunotherapy resistance; tumor microenvironment; epigenetic reprogramming; biomarkers of resistance; clonal evolution

(This special issue belongs to the Section Molecular Cancer Biology)

Oral Cancer Prevention in the Real World: Epidemiology, Inequities, Risk Determinants and Early Interventions

edited by

Rui Amaral Mendes

and

Pia Lopez-Jornet

submission deadline 31 Mar 2027 | Viewed by 514 | Submission Open

Keywords: oral cancer prevention; health inequities; implementation science; risk determinants; early detection; digital health; secondary and tertiary prevention; epidemiology

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Computational Approaches for Multi-Omics and Biomedical Data Analysis in Cancer Research

edited by Joanna Żyła and

Michal Marczyk

submission deadline 31 Mar 2027 | 1 articles | Viewed by 322 | Submission Open

Keywords: computational oncology; AI in cancer research; multi-omics analysis; cancer imaging

(This special issue belongs to the Section Cancer Informatics and Big Data)

Radiation Exposure and Cancer

edited by

Noriaki Yoshida

submission deadline 31 Mar 2027 | Viewed by 299 | Submission Open

Keywords: radiation; cancer; epidemiology; clinical research; molecular biology; exposomics

Precision Cancer Nanomedicine: Molecular Mechanisms, Predictive Toxicology, and Translational Oncology

edited by Alireza Tavakolpournegari and Arash Matinahmadi

submission deadline 31 Mar 2027 | 1 articles | Viewed by 276 | Submission Open

Keywords: nanomedicine; cancer therapy; nanoparticles; drug delivery; nanotoxicology; tumor microenvironment; theranostics; nanoliposomes; drug resistance; precision oncology

Advances in Biomarker-Driven Targeted Therapies for Cancer: 2nd Edition

edited by

Tianshun Zhang

submission deadline 31 Mar 2027 | Viewed by 272 | Submission Open

Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy

(This special issue belongs to the Section Cancer Therapy)

The Multimodal Management of Advanced Breast Cancers: Integrating Surgery, Radiation, and Systemic Therapies

edited by

Veronica Jones

and Hope S. Rugo

submission deadline 31 Mar 2027 | Viewed by 249 | Submission Open

Keywords: metastatic breast cancer; inflammatory breast cancer; lobular breast cancer; de-escalation; breast sarcoma

(This special issue belongs to the Section Cancer Therapy)

Improving Quality of Life for Glioma Patients: Enhancing Support Access

edited by

Adela Wu

submission deadline 31 Mar 2027 | Viewed by 225 | Submission Open