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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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3D In Vitro Modeling for the Study of Epithelial Cancers

edited by

Sherif M. Karam

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model

(This special issue belongs to the Section Methods and Technologies Development)

Role of Protein and Metabolite in Cancers

edited by

Md. Wasim Khan

submission deadline 31 May 2026 | Submission Open

Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations

(This special issue belongs to the Section Tumor Microenvironment)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2026 | 6 articles | Viewed by 11980 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition

edited by

Arati Sharma

Dhimant Desai

and

Abhijit Date

submission deadline 1 Jun 2026 | 2 articles | Viewed by 8080 | Submission Open

Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation

(This special issue belongs to the Section Cancer Drug Development)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2026 | 3 articles | Viewed by 3325 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Looking for New Biochemical Mechanisms in Cancer: The New Dawn in the Omics Sciences

edited by

Alessia Maria Cossu

, Marco Bocchetti and

Michela Falco

submission deadline 1 Jun 2026 | 1 articles | Viewed by 2340 | Submission Open

Keywords: multi-omics; machine learning; sequencing; signal transduction; molecular mechanisms; circulating biomarker; cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Proton Therapy of Cancer Treatment

edited by Minglei Kang, Benjamin Durkee and Kuo Men

submission deadline 1 Jun 2026 | 3 articles | Viewed by 1703 | Submission Open

Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning

(This special issue belongs to the Section Cancer Therapy)

Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

edited by

Lubna Khaldi

and

Nektarios Koufopoulos

submission deadline 1 Jun 2026 | Viewed by 136 | Submission Open

Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in the Immunotherapy of Metastatic Cancer

edited by

Gianluca Tomasello

submission deadline 5 Jun 2026 | Viewed by 56 | Submission Open

Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Surgical Advances in the Treatment of Gliomas: Preserving Function and Quality of Life

edited by Francesco Vergani and José Pedro Lavrador

submission deadline 7 Jun 2026 | 3 articles | Viewed by 3332 | Submission Open

Keywords: neuro-oncology; brain mapping; neuroimaging; intraoperative neuro-monitoring; functional MRI; transcranial magnetic stimulation; neurorehabilitation

(This special issue belongs to the Section Cancer Therapy)

Histopathology of Urological Cancers

edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan

submission deadline 10 Jun 2026 | 3 articles | Viewed by 6406 | Submission Open

Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Extracellular Vesicles in Cancer Progression

edited by

Susana García-Silva

submission deadline 10 Jun 2026 | Viewed by 20 | Submission Open

Keywords: extracellular vesicles; cancer progression; tumor microenvironment; tumor– immune landscape; cross-talk pre-metastatic and metastatic niches immune surveillance; EV-based biomarkers; EV-based therapeutic development

(This special issue belongs to the Section Tumor Microenvironment)

Innovative Surgical Strategies for Thoracic Malignancies

edited by

Gregor J. Kocher

and

Fabrizio Minervini

submission deadline 10 Jun 2026 | Submission Open

Keywords: robotic thoracic surgery; RATS; uRATS; NSCLC; thoracic malignancies; video-assisted thoracic surgery; VATS; uVATS

(This special issue belongs to the Section Methods and Technologies Development)

Nursing and Supportive Care for Cancer Survivors

edited by

Michela Piredda

submission deadline 12 Jun 2026 | Viewed by 349 | Submission Open

Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jun 2026 | 3 articles | Viewed by 2942 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

edited by

Arezou A. Ghazani

submission deadline 15 Jun 2026 | 3 articles | Viewed by 2829 | Submission Open

Keywords: genome; cancers; oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)

edited by

Jaydira del Rivero

and Aman Chauhan

submission deadline 15 Jun 2026 | Viewed by 233 | Submission Open

Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiotherapy of Gastrointestinal Cancers

edited by

Sunil Krishnan

submission deadline 15 Jun 2026 | Viewed by 29 | Submission Open

Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer

edited by Tomoyuki Hishida

submission deadline 15 Jun 2026 | Viewed by 20 | Submission Open

Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Nanocarriers as an Emerging Platform for Cancer Therapy

edited by

Andrea Markus

and Fernanda Ramos-Gomes

submission deadline 15 Jun 2026 | Viewed by 1 | Submission Open

Keywords: nanoparticles; cancer therapy; nanomedicine; theranostics; chemotherapy; nanocarriers; drug delivery; nanotechnology

(This special issue belongs to the Section Cancer Therapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 70 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | Viewed by 94 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 85 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 48 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 25 Jun 2026 | Viewed by 36 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and Maximilian Deussing

submission deadline 25 Jun 2026 | Viewed by 5 | Submission Open

Keywords: dermatology ; digital pathology ; ex vivo confocal microscopy ; artificial intelligence ; machine learning ; virtual biopsy ; teledermatology ; histopathological images; image analysis algorithms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Strategies for Molecular Targeted Therapy in Multiple Myeloma

edited by Daniele Caracciolo

submission deadline 26 Jun 2026 | Viewed by 21 | Submission Open

Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 9 articles | Viewed by 21948 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 18053 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 7 articles | Viewed by 15679 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 30 Jun 2026 | 4 articles | Viewed by 14330 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 6 articles | Viewed by 9615 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Clinical Diagnosis, Treatment, and Prognosis of Uveal Melanoma

edited by Josep Maria Caminal Mitjana

submission deadline 30 Jun 2026 | 5 articles | Viewed by 8392 | Submission Open

Keywords: uveal melanoma; choroidal melanoma; gene expression profiling; immunotherapy; metastasis; radiotherapy; liquid biopsy; circulating tumor cells; brachytherapy; next-generation sequencing; proton therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 6 articles | Viewed by 8340 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

Advances in Abdominal Surgical Oncology and Intraperitoneal Therapies

edited by

Juan Jose Segura-Sampedro

and

Constantino Fondevila

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5429 | Submission Open

Keywords: abdominal oncologic surgery; minimally invasive techniques; laparoscopy; robotics; fluorescence; artificial intelligence; augmented vision; peritoneal carcinomatosis; intraperitoneal chemotherapy; liquid biopsy

(This special issue belongs to the Section Cancer Therapy)

Epigenetic Regulation in Hematologic Malignancies

edited by Travis S. Johnson

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5216 | Submission Open

Keywords: epigenetic regulation; hematologic malignancies; DNA methylation; non-coding RNA; therapeutic targeting

(This special issue belongs to the Section Tumor Microenvironment)

The Progress of Pancreatectomy for Pancreatic Cancer Treatment

edited by

Reinhold Függer

and

Matthias Biebl

submission deadline 30 Jun 2026 | 3 articles | Viewed by 4399 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); pancreatectomy timing in multimodal regimen; minimally invasive pancreatectomy for PDAC; pancreatectomy and resectability; extended pancreatectomy; vascular resection and reconstruction; outcome research— pancreatectomy for cancer in unselected patient cohorts; interaction of postoperative complications and preoperative or adjuvant therapy; postoperative pancreatic fistula

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Neutrophils in Tumor Progression and Metastasis

edited by

Rakesh K. Singh

and Leah M. Cook

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3912 | Submission Open

Keywords: neutrophils; innate immunity; tumor; microenvironment; metastasis; targeted therapeutics

(This special issue belongs to the Section Cancer Metastasis)

Applications of Ex Vivo Microscopy in Cancer Detection and Diagnosis

edited by J. Quincy Brown

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2666 | Submission Open

Keywords: microscopy; cancer; optical sectioning; diagnosis; detection

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Applications of Precision Diagnosis for Thyroid Cancers and Its Clinical Use for Treatments Choice

edited by

Maria Trovato

, Silvia Martina Ferrari and

Fausto Famà

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1956 | Submission Open

Keywords: thyroid cancer; precision diagnosis; clinical management; molecular tests; molecular therapeutic targets; thyroid cancer epidemiology; artificial intelligence; health inequalities

(This special issue belongs to the Section Clinical Research of Cancer)

Feature Review Papers on Cancer Epidemiology, Disparities, and Prevention

edited by Adam Barsouk

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1931 | Submission Open

Keywords: epidemiology; disparities; oncology; cancer; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Neuroscience of Brain Tumors

edited by Zefferino Rossini,

Miguel Segura Ginard

and Maria Pia Tropeano

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1733 | Submission Open

Keywords: neurosurgery; neuroscience; brain tumors (gliomas; meningiomas; and pituitary tumors); neural pathway; neuroimaging; neurogenetics

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Neurofibromatosis

edited by Yunjia Chen and Yulong Fu

submission deadline 30 Jun 2026 | 1 articles | Viewed by 811 | Submission Open

Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1

(This special issue belongs to the Section Molecular Cancer Biology)

Integrating Precision Medicine with Nanotechnology to Overcome Drug Resistance in Cancer

edited by Yan Li

submission deadline 30 Jun 2026 | 1 articles | Viewed by 790 | Submission Open

Keywords: precision medicine; nanotechnology; drug resistance

(This special issue belongs to the Section Methods and Technologies Development)

Advances in PET/CT for Predicting Cancer Outcomes

edited by Ahmad Shariftabrizi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 700 | Submission Open

Keywords: FDG PET/CT; PSMA PET/CT; dotatate PET/CT; tumor heterogeneity; radiomics; CAR T-cell therapy; rare tumors; radiogenomics; immunotherapy; targeted therapy; PET physics; radiotracer metabolism

(This special issue belongs to the Section Methods and Technologies Development)

Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition)

edited by

Daochun Sun

and

Sameer Farouk Sait

submission deadline 30 Jun 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials

(This special issue belongs to the Section Tumor Microenvironment)

Understanding the Molecular Basis and Immunobiology of Renal Cell Carcinoma and Exploring Novel Therapeutic Strategies

edited by

Heba Khella

submission deadline 30 Jun 2026 | Viewed by 361 | Submission Open

Keywords: renal cell carcinoma; molecular basis; immunobiology; tumor microenvironment; immunotherapy; targeted therapy; metastasis; precision medicine; biomarkers; non-coding RNA; miRNA; prognosis; molecular diagnostics; translational research

(This special issue belongs to the Section Cancer Therapy)

Recent Updates on Treatment of Uveal Melanoma

edited by Richard D. Carvajal, Shaheer Khan and Brian Peter Marr

submission deadline 30 Jun 2026 | Viewed by 310 | Submission Open

Keywords: uveal melanoma; systemic therapies; surgical innovations; radiotherapy; genetic and molecular insights; translational research

(This special issue belongs to the Section Cancer Therapy)

Cancer Inhibitory Receptors: Targeting Tumor Microenvironment Therapeutically

edited by

Vaishali Aggarwal

and Alok Kumar

submission deadline 30 Jun 2026 | Viewed by 283 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; tumor microenvironment; inhibitory receptors; immune system; T cells; malignant cells; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Innovative Treatments Based on Genomic Aberrations in Leukemia and Lymphoma

edited by