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Cancers
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Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications
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Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research in Cancer".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 813

Editors

Dr. Francesco Mattioli

E-Mail Website
Guest Editor
Department of Otorhinolaryngology—Head and Neck Surgery, Azienda Ospedaliero—Universitaria Policlinico di Modena, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: head and neck surgery; head and neck tumors; laryngeal cancer; phonosurgery; oral cancer; pediatric and adult airways; tracheal disease
Dr. Alfredo Lo Manto

E-Mail Website
Guest Editor
Department of Otorhinolaryngology—Head and Neck Surgery, Ospedale Infermi di Rimini, 47923 Rimini, Italy
Interests: head and neck surgery; head and neck tumors; laryngeal cancer; phonosurgery; oral cancer
Dr. Edoardo Serafini

E-Mail Website
Guest Editor
Department of Otorhinolaryngology and Audiology, IRCCS Policlinico Sant’Orsola Malpighi, 40138 Bologna, Italy
Interests: head and neck surgery; head and neck tumors; laryngeal cancer; phonosurgery; oral cancer; tracheal disease

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue on laryngeal tumors, which represent the most common malignancies within head and neck cancers. Over the years, technological advancements have introduced more accurate diagnostic tools, such as high-definition videolaryngoscopes with narrow-band imaging (NBI) filters that allow for earlier diagnosis of these tumors. In the staging process, the increased use of magnetic resonance imaging (MRI) with surface coils has allowed for a more precise diagnostic workup. As a result, treatment choices have become more tailored to the individual patient. Approaches have evolved from total laryngectomy to the concept of modular laryngectomy, with organ function preservation, and in some cases, to transoral laser microsurgery and robotic procedures.

The present Special Issue aims to provide an overview of the latest evidence on the management of laryngeal cancer, focusing on, but not limited, diagnostic tools and emerging perspectives in precision medicine, as well as on therapeutic and rehabilitative strategies that have improved the quality of life of patients, ensuring oncologic outcomes. Both original research articles and review papers are welcome for submission. We look forward to receiving your contributions.

Dr. Francesco Mattioli
Dr. Alfredo Lo Manto
Dr. Edoardo Serafini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • laryngeal cancers
  • diagnosis
  • laryngeal surgery
  • transoral laser microsurgery
  • transoral robotic surgery

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Published Papers (1 paper)

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Research

21 pages, 2196 KB  
Article
Factors Associated with Replacement Interval and Complications of Provox Voice Prostheses in Post-Laryngectomy Patients: A Single-Center Retrospective Recurrent-Event Analysis
by Dominik Pawlicki, Marta Gamrot-Wrzoł, Olga Karłowska-Bijak, Tomasz Stącel, Michał Napierała, Maciej Misiołek and Paweł Sowa
Cancers 2026, 18(16), 2545; https://doi.org/10.3390/cancers18162545 - 7 Aug 2026
Viewed by 283
Abstract
Background/Objectives: Indwelling tracheoesophageal prostheses have a limited lifespan and require repeated replacement. We examined the determinants of the replacement interval. Methods: This study conducted a retrospective single-center analysis of 147 consecutive Provox replacements in 82 laryngectomized patients (June 2024–February 2026), reported [...] Read more.
Background/Objectives: Indwelling tracheoesophageal prostheses have a limited lifespan and require repeated replacement. We examined the determinants of the replacement interval. Methods: This study conducted a retrospective single-center analysis of 147 consecutive Provox replacements in 82 laryngectomized patients (June 2024–February 2026), reported according to STROBE, using mixed-effects and gap-time recurrent-event models. Results: Median device survival was 141 days. Prior irradiation was associated with a shorter interval (−38.3 days; 95% CI −67.2 to −9.3; p = 0.010), with a gradient by treatment intensity: the median survival was 179, 136, and 84 days after primary surgery, radiotherapy alone, and chemoradiotherapy (log-rank p < 0.001; cluster-robust hazard ratios 2.19 and 5.13 against primary surgery). A higher cumulative replacement burden—in terms of lifetime exchanges per patient, with a median of eight and range of 1–28—was also associated with shorter intervals (β = −3.70 days per additional lifetime exchange; 95% CI −5.84 to −1.57), but it summarizes the same event process as the outcome and is reported as a phenotype marker. Intervals ending in elective exchange were longer (β = 35.47 days; 95% CI 15.80 to 55.14), but in the primary recurrent-event model, containing only covariates fixed at interval start and retaining censored intervals, elective placement showed no association with device lifetime (HR 0.574; 95% CI 0.309–1.066; p = 0.079); between-patient heterogeneity remained substantial (θ = 0.452; p = 0.002). Complications occurred in seven of 147 procedures (4.8%), which were all managed without life-threatening events. Conclusions: Prior oncological treatment, particularly chemoradiotherapy, is associated with materially shorter device survival and can be used to identify patients likely to require more frequent exchange. Outpatient exchange appears safe. The association between elective replacement and longer intervals reflects conditioning inherent in comparing scheduled with failure-driven exchange, not a benefit of scheduling. Full article
(This article belongs to the Special Issue Laryngeal Cancer: Diagnostic Workup, Treatment, and Complications)
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