Immune Profiling in Gastrointestinal Cancers: Implications for Precision Immunotherapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 26
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will be dedicated to exploring current advances and emerging methodologies in immune profiling specifically applied to gastrointestinal (GI) cancers. Immune profiling represents a powerful tool that allows the detailed characterization of the tumor immune microenvironment, identifying distinct immune cell populations, their functional states, and their roles in tumor progression and response to immunotherapies. Precise immune characterization facilitates the discovery and validation of predictive biomarkers, enabling the optimization of immunotherapeutic approaches tailored to individual patient profiles.
This Special Issue will include studies covering various GI malignancies, such as colorectal cancer, gastric carcinoma, pancreatic cancer, and hepatobiliary cancers. Contributions are invited that investigate tumor-infiltrating lymphocytes, regulatory immune subsets (including Tregs, NK cells, macrophages, and dendritic cells), and the complex interactions between immune cells and tumor cells. Additionally, this Special Issue will explore the potential of non-invasive biomarkers derived from circulating immune cells, microbiota–immunity interactions influencing therapy outcomes, and novel technologies such as single-cell sequencing and spatial transcriptomics applied to immune profiling.
We encourage submissions of original research articles, comprehensive reviews, and short communications that address the use of methodological advancements, biomarker identification, immune cell heterogeneity, immune resistance mechanisms, and translational strategies to enhance precision medicine and improve personalized immunotherapy outcomes in patients suffering from gastrointestinal cancers.
Dr. Paulina Mertowska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- gastrointestinal cancer
- immune profiling
- immunocompetent cells
- personalized immunotherapy
- biomarkers
- precision medicine
- tumor microenvironment
- tumor-infiltrating lymphocytes
- immune checkpoint inhibitors
- microbiota–immunity interactions
- single-cell analysis
- spatial transcriptomics
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