Conversion Surgery for Initially Unresectable, Locally Advanced, Metastatic or Recurrent Gastrointestinal Cancers
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 33
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, remarkable advances in chemotherapy, radiotherapy, molecular targeted therapy, and particularly immunotherapy have made it possible to achieve long-term tumor control even in gastrointestinal cancers with locally advanced disease or distant metastases. As a result, the efficacy of conversion surgery in patients who have responded favorably to such treatments is being increasingly reported. Notably, in selected cases of distant metastasis—so-called oligometastases—curative treatment may be achievable.
This Special Issue aims to explore the role of conversion surgery for malignant tumors in the gastrointestinal and hepatobiliary-pancreatic regions. We warmly invite submissions that discuss the characteristics of patients eligible for conversion surgery, treatment outcomes according to prior therapies, and both short- and long-term postoperative results in order to clarify the clinical value of this approach.
Through this initiative, we hope to contribute to the advancement of multidisciplinary treatment strategies and to offer new curative options for patients who were once considered untreatable.
This Special Issue welcomes original research articles, review articles, and translational research papers. The central theme is conversion surgery with curative intent following chemotherapy, molecular targeted therapy, and/or radiotherapy for gastrointestinal cancers, including those that are locally advanced, metastatic (e.g., oligometastatic), or recurrent. The primary cancer types of interest include esophageal cancer, gastric cancer, malignant tumors of the small intestine, colorectal cancer, pancreatic cancer, biliary tract cancer, and primary liver cancer.
We look forward to receiving your valuable contributions.
Dr. Takashi Murakami
Guest Editor
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Keywords
- conversion surgery
- locally advanced disease
- metastatic disease
- chemotherapy
- radiotherapy
- immunotherapy
- heptobiliary-pancreatic cancers
- gastrointestinal tract cancers
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