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Cancers
Special Issues
Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)
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Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition)

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 18 February 2026 | Viewed by 580

Special Issue Editors

Dr. Anna Kakehashi

E-Mail Website
Guest Editor
Department of Molecular Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 545-8585, Japan
Interests: gastrointestinal cancer; diagnosis; biomarker; anti-cancer drug; molecular mechanisms
Special Issues, Collections and Topics in MDPI journals
Dr. Min Gi

E-Mail Website
Guest Editor
School of Medicine, Osaka Metropolitan University, Osaka, Japan
Interests: gastrointestinal cancer

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of "Diagnosis, Treatment and Prevention of Gastrointestinal Cancer".

The discovery of novel strategies for gastrointestinal cancer diagnosis, treatment and prevention remains a matter of utmost importance. In our efforts to develop effective therapies and anti-cancer drugs, recent research has focused on innovative molecular, biochemical, pathological and immunological developments. In this respect, investigation into the mechanisms of carcinogenesis is crucial for the development of cancer screening methods and therapies for application in clinical practice. Furthermore, the discovery of new chemopreventive agents can also help in the fight against cancer.

This Topical Collection will present an overview of the most recent studies on advancements in cancer diagnosis, anti-cancer drugs and chemopreventive agents for gastrointestinal cancers. Topics of interest include (1) cancer diagnosis, (2) carcinogenesis models for the discovery of cancer risk factors, (3) innovative drugs and chemopreventive agents, (4) investigation into the molecular mechanisms of carcinogenesis, (5) the discovery of novel cancer biomarkers and molecular targets, and (6) innovative preclinical studies.

Dr. Anna Kakehashi
Dr. Min Gi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • screening
  • diagnosis
  • anti-cancer
  • drugs
  • mechanisms of carcinogenesis
  • chemopreventive agents

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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23 pages, 2431 KiB  
Review
Unraveling the Burden of Pancreatic Cancer in the 21st Century: Trends in Incidence, Mortality, Survival, and Key Contributing Factors
by Jakob Zottl, Christian Günther Sebesta, Elena Tomosel, Marie-Christine Sebesta and Christian Sebesta
Cancers 2025, 17(10), 1607; https://doi.org/10.3390/cancers17101607 - 9 May 2025
Viewed by 483
Abstract
Background: PC has become a significant global health challenge, with incidence and mortality rates rising over the past three decades. While traditionally associated with aging, recent data indicate an increasing burden among younger populations. This study aims to analyze global trends in PC [...] Read more.
Background: PC has become a significant global health challenge, with incidence and mortality rates rising over the past three decades. While traditionally associated with aging, recent data indicate an increasing burden among younger populations. This study aims to analyze global trends in PC incidence and mortality and to identify key contributing factors, particularly modifiable risk factors such as obesity, diabetes, and smoking. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, population-based cancer registries globally and nationally, systematic reviews and analysis trends in PC incidence, mortality and survival were analyzed. To assess epidemiological shifts, we utilized previously published annual percentage change (AAPC) values stratified by region, age group, and sex, as reported in the cited literature. Additionally, the influence of modifiable risk factors was evaluated to determine their contribution to rising incidence rates. Results: Between 1990 and 2021, the global incidence of PC increased by 8.9%, from 5.47 to 5.96 per 100,000, with the highest rates observed in high-Sociodemographic-Index (SDI) regions (10.00 per 100,000) and the lowest in low-SDI regions (1.59 per 100,000). Significant increases in incidence were noted in several countries, particularly among men in Iceland (AAPC 8.85) and women in Malta (AAPC 6.04). Early-onset PC is becoming more prevalent, especially among younger women. Modifiable risk factors, including obesity, diabetes, and smoking, play a critical role, with excess body weight contributing to 17.9% of PC cases and smoking to 13.9% in the United States (U.S.). Conclusions: The rising burden of PC, particularly among younger populations, highlights the need for targeted prevention strategies, early detection efforts, and further research into the underlying mechanisms driving these trends. Addressing modifiable risk factors could be key to mitigating the increasing incidence of this highly lethal cancer. Full article
(This article belongs to the Special Issue Diagnosis, Treatment and Prevention of Gastrointestinal Cancer (2nd Edition))
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