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Cancers
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Novel Approaches in the Management of Gynecological Cancers
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Novel Approaches in the Management of Gynecological Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 804

Special Issue Editors

Dr. Mikel Gorostidi

E-Mail Website
Guest Editor
1. Gynecology Department, Hospital Universitario de Donostia, 20014 San Sebastian, Spain
2. Biogipuzkoa Health Research Institute, San Sebastián, Spain
Interests: surgical oncology; endometrial cancer; cervical cancer; cytoreductive surgery; ovarian cancer; sentinel node; pregnancy; robotics; surgical complications
Dr. Martina Aida Angeles

E-Mail Website
Guest Editor
Gynecologic Oncology Unit, Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain
Interests: surgical oncology; cytoreductive surgery; ovarian cancer; surgical complications
Dr. Ignacio Zapardiel

E-Mail Website1 Website2
Guest Editor
Gynecologic Oncology Unit, La Paz University Hospital, 28046 Madrid, Spain
Interests: Surgical oncology; fertility preservation treatments; rare cancers; uterine sarcoma; vulvar cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of gynecological cancers has increased in the past 10 years. Their management, both surgical and medical, has undergone various improvements and modifications which have positively influenced the oncological outcomes of patients. Novel approaches in such treatment include the implementation of less radical surgeries in cervical cancer patients, avoiding main urologic complications; the use of sentinel node biopsy in the assessment of nodal disease among gynecological cancers; the implementation of immunologic agents in the adjuvant treatment of patients; and the reclassification of tumors according to molecular profiles as a main factor in postoperative management.

The aim of this Special Issue is to disseminate the last evidence regarding the management of gynecological cancers, which will contribute to increasing the survival of the patients or, at least, to decreasing the morbidity of treatments.

Dr. Mikel Gorostidi
Dr. Martina Aida Angeles
Dr. Ignacio Zapardiel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological cancer
  • ovarian cancer
  • endometrial cancer
  • cervical cancer
  • vulvar cancer
  • surgical management
  • clinical management

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Published Papers (1 paper)

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Research

13 pages, 299 KB  
Article
Ovarian Cancer in the Era of Precision Surgery and Targeted Therapies
by Yagmur Sisman, Tim Svenstrup Poulsen, Tine Henrichsen Schnack, Claus Høgdall and Estrid Høgdall
Cancers 2025, 17(20), 3371; https://doi.org/10.3390/cancers17203371 - 18 Oct 2025
Viewed by 586
Abstract
Background: High-grade serous ovarian cancer (HGSC) is the most common and aggressive subtype of ovarian cancer. Despite initial response to platinum-based chemotherapy, most patients relapse. Cytoreductive surgery at relapse has been shown to improve survival in selected patients, but the biological mechanisms underlying [...] Read more.
Background: High-grade serous ovarian cancer (HGSC) is the most common and aggressive subtype of ovarian cancer. Despite initial response to platinum-based chemotherapy, most patients relapse. Cytoreductive surgery at relapse has been shown to improve survival in selected patients, but the biological mechanisms underlying recurrence and resistance remain unclear. This study aimed to investigate whether the mutational profile of HGSC changes from diagnosis to relapse, and to evaluate treatment patterns and survival outcomes in a cohort undergoing cytoreductive surgery. Methods: Sixteen patients with HGSC who underwent cytoreductive surgery at both diagnosis and relapse were included. Matched tumor tissue samples (n = 32) were collected and sequenced using a 501-gene cancer panel. Only pathogenic or likely pathogenic variants were registered. Clinical data, treatment history, and survival outcomes were obtained from medical records, with a median follow-up of 63 months. Results: All patients harbored pathogenic or likely pathogenic mutations, most frequently in TP53 (88%) and BRCA1/2 (38%). The mutational landscape was largely stable, with 15 of 16 patients (94%) showing no mutational changes between diagnosis and relapse. One patient acquired a NOTCH2 mutation at relapse. Complete resection was achieved in 88% of relapse surgeries. Median time to first relapse was 32 months, and overall survival was prolonged, with 87.5% of patients alive at last follow-up. BRCA mutated patients showed longer time to relapse, and overall follow-up compared to BRCA wild-type cases. Conclusions: The somatic mutational profile of HGSC remains remarkably stable from diagnosis to relapse. Clinically, this stability suggests that repeat mutational sequencing at relapse is unlikely to yield new actionable findings and may have limited value in guiding treatment decisions. Instead, resistance mechanisms likely arise from epigenetic or non-genetic changes, underscoring the need for future research in these areas and the continued importance of optimal surgical management in selected patients. Full article
(This article belongs to the Special Issue Novel Approaches in the Management of Gynecological Cancers)
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