Advances in Cancer and Glycosylation

Dear Colleagues,

Over 3-5 decades, altered sialylation of tumor cell surface glycoproteins has been described to be highly associated with the metastatic phenotype of cancer. In an effort to understand this metastatic behavior in relation to altered sialic acid, tumor cell surfaces have been extensively analyzed in the past and present for melanomas, T-cell hybridomas, methylcholanthrene A-induced T-cell lymphoma sublines, B16F10 melanoma cells, metastatic variants, breast, pancreatic, and other cancers. It is now accepted that aberrant sialylation in cancer cells is at least one of the characteristic features associated with the metastatic potential of cancer cells. Interference with sialic acid expression in cancer cells is the current target in preventing metastasis. In particular, desialylation of cancer cells by overexpressing human sialidases has been reported to inhibit metastases in murine metastasis models.

This Special Issue aims to highlight aspects of protein glycosylation in all cancer. Contributions (research articles, reviews, communications) that cover the structural elucidation, function, biosynthesis, or degradation of glycans and the characterization of enzymes involved in cancer processes are very welcome, as are papers dealing with methodical improvements for the analysis of glycans or enzymes recognizing carbohydrate structures.

Prof. Dr. Myron R. Szewczuk
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• glycosylation
• glycobiology
• N-glycans
• O-glycans
• glycosyltransferases
• glycosidases