Advances in Cancer and Glycosylation
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1708
Special Issue Editor
Interests: the role of glycosylation in receptor activation; TOLL-like; nerve growth factor Trk; EGFR and insulin receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over 3-5 decades, altered sialylation of tumor cell surface glycoproteins has been described to be highly associated with the metastatic phenotype of cancer. In an effort to understand this metastatic behavior in relation to altered sialic acid, tumor cell surfaces have been extensively analyzed in the past and present for melanomas, T-cell hybridomas, methylcholanthrene A-induced T-cell lymphoma sublines, B16F10 melanoma cells, metastatic variants, breast, pancreatic, and other cancers. It is now accepted that aberrant sialylation in cancer cells is at least one of the characteristic features associated with the metastatic potential of cancer cells. Interference with sialic acid expression in cancer cells is the current target in preventing metastasis. In particular, desialylation of cancer cells by overexpressing human sialidases has been reported to inhibit metastases in murine metastasis models.
This Special Issue aims to highlight aspects of protein glycosylation in all cancer. Contributions (research articles, reviews, communications) that cover the structural elucidation, function, biosynthesis, or degradation of glycans and the characterization of enzymes involved in cancer processes are very welcome, as are papers dealing with methodical improvements for the analysis of glycans or enzymes recognizing carbohydrate structures.
Prof. Dr. Myron R. Szewczuk
Guest Editor
Manuscript Submission Information
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Keywords
- glycosylation
- glycobiology
- N-glycans
- O-glycans
- glycosyltransferases
- glycosidases
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