Advances in p53 Research

Dear Colleagues,

This Special Issue concerns p53, one of the most intensively studied tumor suppressor proteins that, in some circumstances, can acquire oncogenic function. Since its discovery, many cellular functions have been ascribed to p53, such as transcription regulation and signalling to apoptosis, involvement in the response to stress, senescence, DNA repair, metabolism, immunity, and epigenetic regulation. The perturbation of p53 signalling pathways is required for the development of most cancers, and studies regarding the restoration or reactivation of p53 function have recently showed significant therapeutic benefit. Over half of all human cancers demonstrate alterations in p53 that not only attenuate or eliminate its tumor suppressor function, but can also result in the gain of a novel transforming function, thus contributing to cancer progression. Much knowledge still needs to be acquired regarding the multiple facets of this intriguing protein. Here, we welcome papers describing recent advances in understanding p53 function and dysfunction, with an emphasis on novel molecules which target p53 reactivation for translational purposes.

Dr. Gabriella D’Orazi
Guest Editor

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