Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.4
4.8
Journals
Biomolecules
Special Issues
Nanoparticles for Cancer Therapy: Challenges and Opportunities
share announcement

Nanoparticles for Cancer Therapy: Challenges and Opportunities

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Bio-Engineered Materials".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1447

Special Issue Editors

Dr. Nagavendra Kommineni

E-Mail Website
Guest Editor
Center for Biomedical Research (CBR) Population Council, The Rockefeller University, New York, NY 10065, USA
Interests: drug delivery; nanomedicine; cancer therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Venkatesh Pooladanda

E-Mail Website
Guest Editor
Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA-02114, USA
Interests: cancer biology; nanomedicine; immunology; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomedicine is an emerging field dedicated to addressing a variety of diseases worldwide. Its advancement has led to increased patient life expectancy and the elimination of drug-resistant conditions. The benefits of nanomedicine include enhancements in the pharmacokinetics of therapeutic agents, such as better solubility and bioavailability. This platform not only offers new treatment options but also enhances the precision of disease targeting. Numerous nanomedicines are available on the market, including liposomes, lipid particles, dendrimers, polymeric nanoparticles, and protein nanoparticles. Nanocarriers are instrumental in delivering small molecules, proteins, peptides, and genes directly to the intended site of action.

The limitations of nanomedicine platforms, including the potential toxicity of certain nanomedicines and long-term complications, require thorough investigation. Recent research advancements have highlighted the promising potential of nano delivery systems for administering various biopharmaceuticals. This Special Issue is dedicated to exploring recent progress, methodologies, and strategies in the development of nanocarriers, as well as their characterization techniques for cancer therapy.

In this Special Issue of Biomolecules, the focus will be on nanomedicine platforms for cancer therapy.

Dr. Nagavendra Kommineni
Dr. Venkatesh Pooladanda
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • cancer
  • nanotheranostics
  • drug delivery
  • gene delivery

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

29 pages, 6702 KiB  
Article
Core–Shell PLGA Nanoparticles: In Vitro Evaluation of System Integrity
by Tatyana Kovshova, Julia Malinovskaya, Julia Kotova, Marina Gorshkova, Lyudmila Vanchugova, Nadezhda Osipova, Pavel Melnikov, Veronika Vadekhina, Alexey Nikitin, Yulia Ermolenko and Svetlana Gelperina
Biomolecules 2024, 14(12), 1601; https://doi.org/10.3390/biom14121601 - 14 Dec 2024
Viewed by 1133
Abstract
The objective of this study was to compare the properties of core–shell nanoparticles with a PLGA core and shells composed of different types of polymers, focusing on their structural integrity. The core PLGA nanoparticles were prepared either through a high-pressure homogenization–solvent evaporation technique [...] Read more.
The objective of this study was to compare the properties of core–shell nanoparticles with a PLGA core and shells composed of different types of polymers, focusing on their structural integrity. The core PLGA nanoparticles were prepared either through a high-pressure homogenization–solvent evaporation technique or nanoprecipitation, using poloxamer 188 (P188), a copolymer of divinyl ether with maleic anhydride (DIVEMA), and human serum albumin (HSA) as the shell-forming polymers. The shells were formed through adsorption, interfacial embedding, or conjugation. For dual fluorescent labeling, the core- and shell-forming polymers were conjugated with Cyanine5, Cyanine3, and rhodamine B. The nanoparticles had negative zeta potentials and sizes ranging from 100 to 250 nm (measured using DLS) depending on the shell structure and preparation technique. The core–shell structure was confirmed using TEM and fluorescence spectroscopy, with the appearance of FRET phenomena due to the donor–acceptor properties of the labels. All of the shells enhanced the cellular uptake of the nanoparticles in Gl261 murine glioma cells. The integrity of the core–shell structures upon their incubation with the cells was evidenced by intracellular colocalization of the fluorescent labels according to the Manders’ colocalization coefficients. This comprehensive approach may be useful for the selection of the optimal preparation method even at the early stages of the core–shell nanoparticle development. Full article
(This article belongs to the Special Issue Nanoparticles for Cancer Therapy: Challenges and Opportunities)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop