Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanosensitivity and Ion Channels
edited by Olivia García-Suarez and Yolanda García-Mesa
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3965 | Submission Open
Keywords: mechanosensation; piezo ion channels; mechanosensitivity ion channels; mechanotrasduction
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Mechanisms of Formation of Biomolecule Complexes: Theory, Experiment, Applications submission deadline 31 Dec 2025 | 2 articles | Viewed by 3829 | Submission Open
Keywords: biomolecule complexes; biomolecule coacervates; complex stability; mechanisms of formation of biomolecule complexes; phase separation; application of biomolecule complexes in biomedical industry
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 31 Dec 2025 | 2 articles | Viewed by 3349 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
Functional Peptides and Their Interactions (3rd Edition) submission deadline 31 Dec 2025 | 3 articles | Viewed by 2972 | Submission Open
Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
The Role of Calcium Signaling in Cardiac and Skeletal Muscle submission deadline 31 Dec 2025 | 3 articles | Viewed by 2945 | Submission Open
Keywords: striated muscle; Ca2+ signaling; excitation– contraction coupling; remodeling; inflammation
(This special issue belongs to the Section Molecular Biology)
Molecular Basis of Pathogenesis in Autoimmune Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 2847 | Submission Open
Keywords: autoimmune diseases; molecular pathogenesis; genetic determinants; signaling pathways; immunopathology; therapeutic targets; novel molecular targets
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2646 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
(This special issue belongs to the Section Chemical Biology)
Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism submission deadline 31 Dec 2025 | 2 articles | Viewed by 2639 | Submission Open
Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Chromatin and Chromosome Molecular Research
edited by Xin Bi
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2287 | Submission Open
Keywords: chromatin; chromosome; genome; molecular mechanisms; regulation
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Biomolecular Approaches and Drugs for Neurodegeneration—2nd Edition submission deadline 31 Dec 2025 | 2 articles | Viewed by 2123 | Submission Open
Keywords: proteins; peptides; amyloid; Alzheimer disease; Parkinson’ s disease; neurodrugs; G-quadruplex nucleic acids; biotechnology; biomolecular targets; peptide aggregation; natural products; synthetic drugs; anti-amyloid therapeutics; machine learning
(This special issue belongs to the Section Chemical Biology)
Biomolecules in Myocarditis and Inflammatory Heart Disease
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1779 | Submission Open
Keywords: cardiomyocyte; macrophage; cardiac remodeling; oxidative and nitrosative stress; neutrophils
(This special issue belongs to the Section Molecular Medicine)
Molecular Basis of Mast Cells Activation and Medical Implications submission deadline 31 Dec 2025 | 1 articles | Viewed by 1756 | Submission Open
Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms
(This special issue belongs to the Section Biological Factors)
State-of-the-Art Molecular Structure and Dynamics and Biophysics in Asia
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1688 | Submission Open
Keywords: molecular modeling; molecular dynamics simulation; protein– protein interaction; protein folding; bioinformatics; molecular docking; drug design; machine learning
(This special issue belongs to the Section Chemical Biology)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 31 Dec 2025 | 1 articles | Viewed by 1642 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Vertebrate Comparative Genomics
edited by Ya-Xiong Tao and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1611 | Submission Open
Keywords: vertebrate; comparative genomics; physiology; biochemistry; pathophysiology; protein structure-function; gene
(This special issue belongs to the Section Molecular Genetics)
Ion Channels in Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1502 | Submission Open
Keywords: Na+ channel; Ca2+ channel; K+ channel; TRP channel; store-operated channel; Cl− channel; cation channel; ryanodine receptor; mechanosenstive channels; piezo channels; SGLT-1 transporters; membrane transporters
(This special issue belongs to the Section Biological Factors)
The Value of Natural Compounds as Therapeutic Agents: 3rd Edition submission deadline 31 Dec 2025 | 2 articles | Viewed by 1334 | Submission Open
Keywords: natural compound; acute and chronic conditions; cell proliferation; cell death; cell differentiation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 1313 | Submission Open
Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering
(This special issue belongs to the Section Enzymology)
T Cell Ca2+ Signal Dynamics: An Emerging Landscape for Therapeutic Strategies
edited by David W. Thomas and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1279 | Submission Open
Keywords: T cell signaling; Ca signaling; TCR-activated signals; ER Ca release; ER Ca stores; store-operated Ca influx; ER Ca store depletion signals
(This special issue belongs to the Section Cellular Biochemistry)
Feature Papers in Molecular Biology Section 2025 submission deadline 31 Dec 2025 | 1 articles | Viewed by 1274 | Submission Open
Keywords: mechanobiology; cellular processes including metabolism; proliferation and motility; molecular motors and forces; molecular and biophysical techniques; organelle and membrane transport; exo- and endosomal trafficking; cell and biophysical signal transduction; the biomolecular synthesis of proteins; protein folding and post-translational modification of proteins and macromolecular assemblies
(This special issue belongs to the Section Molecular Biology)
Sperm Nuclear BASIC Proteins: From Chromatin Remodeling to Drug Development and Innovative Clinical Applications submission deadline 31 Dec 2025 | 1 articles | Viewed by 1230 | Submission Open
Keywords: sperm nuclear basic proteins (SNBPs); spermatogenesis; epigenetics; drug development; chromatin remodeling; biomarkers of fertility; translational reproductive medicine
(This special issue belongs to the Section Cellular Biochemistry)
Biomolecules and Their Impact on Biology and Translational Applications: Celebrating the Pioneering Work of Prof. Ho Jeong Kwon: 2nd Edition
edited by and Jiho Yoo
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1196 | Submission Open
Keywords: biomolecules; cancer; angiogenesis; autophagy; GPCRs; translational applications; target identification; proximity-labeling; molecular docking; molecular probe; molecular pharmacology
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1107 | Submission Open
Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health
Design, Synthesis, and Evaluation of New Anticancer Substances and Radiopharmaceuticals
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 967 | Submission Open
Keywords: synthesis; anticancer activity; radiopharamceuticals; organic compounds; medicinal chemistry
(This special issue belongs to the Section Chemical Biology)
Advances in Computational Biology of Intrinsically Disordered Proteins
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 902 | Submission Open
Keywords: intrinsic disorder; compositional bias; prions; protein annotation; protein simulation
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Immune Response to Allergens submission deadline 31 Dec 2025 | Viewed by 886 | Submission Open
Keywords: allergy; immune response; allergen; sensitization; molecular allergology; diagnostics; specific immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Phytohormones 2024–2025
edited by Guzel Kudoyarova
submission deadline 31 Dec 2025 | Viewed by 881 | Submission Open
Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications
edited by and Eleonora Martegani
submission deadline 31 Dec 2025 | 1 articles | Viewed by 866 | Submission Open
Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits
(This special issue belongs to the Section Molecular Biology)
Plant Molecular Stress Physiology—Elucidation of Plant Responses and Defense Mechanisms Against Stress
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 587 | Submission Open
Keywords: plant stress responses; biotic and abiotic stresses; molecular mechanisms of plant stress; plant defense mechanisms; stress tolerance in plants; signaling pathways in plant stress; gene-expression changes under stress; genomic tools for plant stress research; biotechnological approaches for stress-tolerant plants; adaptation strategies of plants to stress; physiological changes in plants under stress; crop resilience to stress; horticultural plant stress physiology; stress-related signaling molecules in plants; practical agricultural applications of stress research
(This special issue belongs to the Section Molecular Biology)
Function and Regulation of Hyaluronan and Hyalectins in Disease submission deadline 31 Dec 2025 | 1 articles | Viewed by 585 | Submission Open
Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling
(This special issue belongs to the Section Chemical Biology)
Genetic Insights into Cardiomyopathy: From Mechanisms to Medicine
edited by Xiao Fan and Youngil Lee
submission deadline 31 Dec 2025 | 1 articles | Viewed by 565 | Submission Open
Keywords: cardiomyopathy; genetics; epigenetics; genomics; genotype– phenotype correlation; genetic penetrance; precision medicine; mitochondria; personalized treatment; gene therapy
(This special issue belongs to the Section Molecular Genetics)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 31 Dec 2025 | Viewed by 418 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Harnessing the Immune System Against Solid Cancer: New Targets and Novel Therapeutic Approaches submission deadline 31 Dec 2025 | Viewed by 357 | Submission Open
Keywords: immune response in cancer; molecular mechanisms of immunosuppression; cysteine proteases and their inhibitors
(This special issue belongs to the Section Molecular Biology)
Recent Developments in Organometallic Syntheses for Biomedical Applications
edited by Bala Moku
submission deadline 31 Dec 2025 | Viewed by 346 | Submission Open
Keywords: advanced organometallic syntheses; biomedical applications; drug discovery; disease treatment; imaging; targeted therapy
(This special issue belongs to the Section Molecular Medicine)
Immunofluorescent Techniques in Animal Stem Cell Research
edited by and Andrea Svoradová
submission deadline 31 Dec 2025 | Viewed by 346 | Submission Open
Keywords: animal stem cells; fluorescence/confocal microscopy; flow cytometry; fluorescence-activated cell sorting; fluorescent protein assay; stem cell markers; cell therapy; drug screening; exosomes; DNA analysis
(This special issue belongs to the Section Molecular Biology)
Sjogren’s Syndrome: Recent Updates and Perspectives
edited by
submission deadline 31 Dec 2025 | Viewed by 329 | Submission Open
Keywords: Sjogren’ s syndrome; autoimmune inflammatory disease; genetics; biomarkers; Toll-like receptors; inflammasome chemokines
Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies
edited by Takashi Onodera and
submission deadline 31 Dec 2025 | Viewed by 319 | Submission Open
Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)
Molecular Mechanisms Underlying Liver Diseases: 2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 288 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ– organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
State-of-the-Art Perspectives on tRNA and tRNA Aminoacylation
edited by
submission deadline 31 Dec 2025 | Viewed by 257 | Submission Open
Keywords: tRNA; tRNA Aminoacylation; translation; tRNA processing and modification
(This special issue belongs to the Section Molecular Genetics)
Molecular and Cellular Mechanisms of Aortic Aneurysms
edited by Maria Giovanna Scioli
submission deadline 31 Dec 2025 | Viewed by 248 | Submission Open
Keywords: aorthopaties; thoracic and abdominal aneurysms; pathogenetic mechanisms; aortic wall degeneration; biomarkers; targeted therapies
(This special issue belongs to the Section Molecular Biology)
Ion Channels in Neurological and Psychological Disorders
edited by
submission deadline 31 Dec 2025 | Viewed by 215 | Submission Open
Keywords: ion channels; neurological disorders; psychological disorder; brain; therapeutic target
(This special issue belongs to the Section Molecular Biology)
Emerging Insights into the Role of Polyamines in Cellular Metabolism and Function submission deadline 31 Dec 2025 | Viewed by 211 | Submission Open
Keywords: polyamine metabolism; putrescine; spermidine; spermine; polyamines in development; polyamines in health and disease; polyamines in cancer; polyamines in plant physiology
(This special issue belongs to the Section Cellular Biochemistry)
p53 Family: The Molecular Landscape in Cancer and Beyond
edited by and Michele Pellegrino
submission deadline 31 Dec 2025 | Viewed by 194 | Submission Open
Keywords: p53 family; microRNA; tumorigenesis; aging; neurodegenerative diseases; immune regulation; biomarkers; therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Genetics and Molecular Breeding in Plants: Advances, Applications, and Future Directions
edited by Yurong Xie and Hongbin Wei
submission deadline 31 Dec 2025 | Viewed by 193 | Submission Open
Keywords: molecular genetics; molecular breeding; genome editing (CRISPR); omics technologies; stress resilience; trait discovery; genomic selection; sustainable agriculture; crop improvement; artificial intelligence in breeding
(This special issue belongs to the Section Molecular Genetics)
Proteogenomics in Cancer Research
edited by
submission deadline 31 Dec 2025 | Viewed by 190 | Submission Open
Keywords: bioinformatics; cancer research; proteogenomics; drug resistance; functional genomics
Lung Cancer: From Molecular Basis to Therapy
edited by
submission deadline 31 Dec 2025 | Viewed by 186 | Submission Open
Keywords: biomarkers; prognostic factors; predictive factors; genetic mutations and oncogenes; tumor suppressor genes; immune checkpoints and PD-L1; proteomic; genomic; radiomic
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Retinal Biology: Focus on Inflammation, Metabolism, and Retinal Dysfunction
edited by , Qiuhua Yang, , and
submission deadline 31 Dec 2025 | Viewed by 159 | Submission Open
Keywords: inflammation; metabolism; neovascularization; retinal degeneration; photoreceptors; Muller glia; RPE
(This special issue belongs to the Section Molecular Medicine)
Design, Synthesis, and Therapeutic Applications of Heterocycles for Major and Neglected Diseases
edited by , and Arun Raja
submission deadline 31 Dec 2025 | Viewed by 151 | Submission Open
Keywords: heterocyclic compounds; medicinal chemistry; drug design; synthetic methodology; structure– activity relationship (SAR); major diseases; neglected tropical diseases; pharmacology
(This special issue belongs to the Section Chemical Biology)
Ocular Surface and Corneal Diseases: From Cellular and Molecular Biology to Therapeutic Strategies
edited by and Pragnya Rao Donthineni
submission deadline 31 Dec 2025 | Viewed by 145 | Submission Open
Keywords: dry eye disease; dry eye; aqueous tear deficiency; evaporative deficiency; ocular surface inflammation; tear osmolarity; epidemiology; limbal stem cell deficiency; neuropathic ocular pain; neurotrophic keratitis
(This special issue belongs to the Section Cellular Biochemistry)
Antituberculous Drugs: Progress and Challenges
edited by and Ana Maria Telmo Dias Pereira Vicente Cabral
submission deadline 31 Dec 2025 | Viewed by 141 | Submission Open
Keywords: antituberculostatic drugs; carriers; bioavailability; delivery systems
(This special issue belongs to the Section Chemical Biology)
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