The Value of Natural Compounds as Therapeutic Agents: 3rd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-derived Molecules".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 738

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a third edition of a Special Issue on the “The Value of Natural Compounds as Therapeutic Agents: 3rd Edition”.

Naturally occurring substances have long been used by humans for medicinal purposes, as concoctions or concentrated extracts. At present, natural products are gaining popularity. A number of pathological conditions have been treated with plant-derived medicines, including cancer and inflammation.

Therefore, in this Special Issue, we aim to unite experts and scientists who work on natural compounds to gather information and data about their involvement in a wide variety of biological mechanisms at the cellular level. The Special Issue will predominantly focus on cellular processes, such as proliferation and survival, apoptosis, dormancy, differentiation, autophagy and senescence, migration, and invasion. Additionally, analyses of soluble mediators involved with microenvironment modulation will be appreciated.

In summary, we would like to emphasize the existing evidence regarding the various potential advantages of plant extracts and plant extract-based products, in regard to human health. Therefore, we encourage submissions of manuscripts that utilize structurally defined natural products or their derivatives, or well-characterized mixtures. We welcome original research articles, review articles, and communications.

Dr. Maria Beatrice Morelli
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural compound
  • acute and chronic conditions
  • cell proliferation
  • cell death
  • cell differentiation

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Published Papers (1 paper)

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Research

21 pages, 2253 KB  
Article
Anticancer Activity of Jania rubens in HCT-116 Cells via EMT Suppression, TET Downregulation, and ROS-Mediated Cytotoxicity
by Zeina Radwan, Rayan Kassir, Fouad Al Feghaly, Rouaa Zaiter, Mira Abou Daher, Rabih Roufayel, Ziad Fajloun, Hiba Mawlawi, Marwan El-Sabban and Zeina Dassouki
Biomolecules 2025, 15(10), 1361; https://doi.org/10.3390/biom15101361 - 25 Sep 2025
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Abstract
The red seaweed Jania rubens (J. rubens) is prevalent along the Lebanese coast and has drawn attention for its notable antineoplastic properties. Our previous data showed that its dichloromethane–methanol (DM) extract possesses antioxidant, cytotoxic, and anti-migratory effects on colon cancer cells. [...] Read more.
The red seaweed Jania rubens (J. rubens) is prevalent along the Lebanese coast and has drawn attention for its notable antineoplastic properties. Our previous data showed that its dichloromethane–methanol (DM) extract possesses antioxidant, cytotoxic, and anti-migratory effects on colon cancer cells. In the present study, a GC-MS analysis of DM extract identified a diverse profile of bioactive compounds, including flavonoids and pyrazole derivatives with antioxidant and anticancer activities. In vitro assays demonstrated that the DM extract exerts significant cytotoxic activity against various cancer cell lines, including colon, breast, and cervical types. Further investigation into the underlying molecular mechanisms revealed that the extract induces G2/M cell cycle arrest and reduces the expression of EMT (epithelial–mesenchymal transition) markers, N-cadherin and Twist. In addition, the extract showed anti-metastatic properties through its ability to decrease MMP-2 and MMP-9 activity. Mechanistically, DM caused a substantial reduction in Ten-Eleven Translocation (TET) enzymes TET-1, TET-2, and TET-3, which are essential DNA demethylation regulators, thus decreasing their enzymatic product 5-hydroxymethylcytosine (5-hmC). Interestingly, despite a significant increase in intracellular ROS (reactive oxygen species), suggesting a contribution to cytotoxicity, no substantial change in the biogenesis of promyelocytic leukemia nuclear bodies (PML-NBs) was detected. These findings demonstrate that J. rubens DM extract contains bioactive compounds with multiple anticancer effects, thus making it a promising candidate for developing new therapeutic agents. Full article
(This article belongs to the Special Issue The Value of Natural Compounds as Therapeutic Agents: 3rd Edition)
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