Novel Mechanisms of Bacterial Antibiotic Resistance
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1589
Special Issue Editor
Interests: microbial functional genomics of global regulators; antibiotic resistance mechanisms in emerging opportunistic bacterial pathogens; beta-lactamases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bacterial antibiotic resistance poses a significant threat to global public health and can render standard therapeutic regimens for infectious diseases ineffective, leading to increased morbidity and mortality. As bacterial pathogens evolve and adapt, it is crucial to understand the molecular mechanisms underlying resistance. Such knowledge informs effective treatment strategies, infection control, and drug development. Known mechanisms of bacterial antibiotic resistance include enzymatic modification or degradation of antibiotics, altered target sites through chromosomal mutations, efflux pumps and decreased drug permeability, and biofilm formation. This Special Issue of Biomolecules will be focused on novel molecular mechanisms that enable bacteria to resist and survive in the presence of antibiotics. Manuscripts elucidating resistome profiles, environmental reservoirs of resistance genes and dissemination to pathogenic bacteria, and the distribution of resistance determinants in clinical isolate populations will also be very welcome. Submissions exploring antibiotic resistance mechanisms by using comparative genomic, bioinformatic, and phylogenetic approaches will also be in line with the topic of this Special Issue. Original research articles, reviews, communications, and editorials will all be considered for publication.
Dr. Dorothea K. Thompson
Guest Editor
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Keywords
- molecular mechanisms of antibiotic resistance
- bacterial resistome acquired and intrinsic
- drug resistance antibiotic modification/degradation
- antibiotic efflux
- antibiotic target modification antibiotic permeability
- antibiotic sequestration proteins
- beta-lactamases
- bioinformatic and phylogenetic approaches
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